The chemokine superfamily: Crosstalk with the IL-1 system

Immunobiology

Volumn 195, Issue 4-5, 1996, Pages 522-549

  Mantovani, Alberto ^a,b   Locati, Massimo ^a   Allavena, Paola ^a   Sozzani, Silvano ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; INTERLEUKIN 1;

ATHEROSCLEROSIS; BASOPHIL; CHEMOTAXIS; CONFERENCE PAPER; DENDRITIC CELL; INFLAMMATION; MOLECULAR INTERACTION; MONOCYTE; NATURAL KILLER CELL; NEOPLASM; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0029828855     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(96)80020-9     Document Type: Conference Paper

References (163)

1. SPRINGER, T. A. 1994. Traffic signal for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301.
2. OPPENHEIM, J. J., C. O. ZACHARIAE, N. MUKAIDA, and K. MATSUSHIMA. 1991. Properties of the novel proinflammatory supergene «intercnne» cytokine family. Annu. Rev. Immunol. 9: 617.
3. BAGGIOLINI, M., B. DEWALD, and B. MOSER. 1994. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv. Immunol. 55: 99.
4. KELNER, G. S., J. KENNEDY, K. B. BACON, S. KLEYENSTEUBER, D. A. LARGAESPADA, N. A. JENKINS, N. G. COPELAND, J. F. BAZAN, K. W. MOORE, T. J. SCHALL, and A. ZLOTNIK. 1994. Lymphotactin: A cytokine that represents a new class of chemokine. Science 266: 1395.
5. WARD, P. A., H. G. REMOLD, and J. R. DAVID. 1970. The production by antigen-stimulated lymphocytes of a lekotactic factor distinct from migration inhibitory factor. Cell Immunol. 1: 162.
6. MELTZER, M. S., M. M. STEVENSON, and E. J. LEONARD. 1977. Characterization of macrophage chemotaxis in tumor cell cultures and comparison with lymphocyte-derived chemotactic factors. Cancer Res. 37: 721.
7. BOTTAZZI, B., N. POLENTARUTTI, R. ACERO, A. BALSARI, D. BORASCHI, P. GHEZZI, M. SALMONA, and A. MANTOVANI. 1983. Regulation of the macrophage content of neoplasms by chemoattractants. Science 220: 210.
8. BOTTAZZI, B., N. POLENTARUTTI, A. BALSARI, D. BORASCHI, P. GHEZZI, M. SALMONA, and A. MANTOVANI. 1983. Chemotactic activity for mononuclear phagocytes of culture supernatants from murine and human tumor cells: evidence for a role in the regulation of the macrophage content of neoplastic tissues. Int. J. Cancer 31: 55.
9. BOTTAZZI, B., P. GHEZZI, G. TARABOLETTI, M. SALMONA, N. COLOMBO, C. BONAZZI, C. MANGIONI, and A. MANTOVANI. 1985. Tumor-derived chemotactic factor(s) from human ovarian carcinoma: evidence for a role in the regulation of macrophage content of neoplastic tissues. Int. J. Cancer 36: 167.
10. MANTOVANI, A., B. BOTTAZZI, F. COLOTTA, S. SOZZANI, and L. RUCO. 1992. The origin and function of tumor-associated macrophages. Immunol. Today 13: 265.
11. VALENTE, A. J., S. R. FOWLER, E. A. SPRAGUE, J. L. KELLEY, C. A. SUENRAM, and C. J. SCHWARTZ. 1984. Initial characterization of a peripheral blood mononuclear cell chemoattractant derived from cultured arterial smooth muscle cells. Am. J. Pathol. 117: 409.
12. ZULLO, J. N., B. H. COCHRAN, A. S. HUANG, and C. D. STILES. 1985. Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell 43: 793.
13. ROLLINS, B. J., E. D. MORRISON, and C. D. STILES. 1988. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc. Natl. Acad. Sci. USA 85: 3738.
14. YOSHIMURA, T., E. A. ROBINSON, S. TANAKA, E. APPELLA, J. KURATSU, and E. J. LEONARD. 1989. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J. Exp. Med. 169: 1449.
15. MATSUSHIMA, K., C. G. LARSEN, G. C. DUBOIS, and J. J. OPPENHEIM. 1989. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J. Exp. Med. 169: 1485.
16. ZACHARIAE, C. O., A. O. ANDERSON, H. L. THOMPSON, E. APPELLA, A. MANTOVANI, J. J. OPPENHEIM, and K. MATSUSHIMA. 1990. Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. J. Exp. Med. 171: 2177.
17. VAN DAMME, J., B. DECOCK, J. P. LENAERTS, R. CONINGS, R. BERTINI, A. MANTOVANI, and A. BILLIAU. 1989. Identification by sequence analysis of chemotactic factors for monocytes produced by normal and transformed cells stimulated with virus, double-stranded RNA or cytokine. Eur. J. Immunol. 19: 2367.
18. GRAVES, D. T., Y. L. JIANG, M. J. WILLIAMSON, and A. J. VALENTE. 1989. Identification of monocyte chemotactic activity produced by malignant cells. Science 245: 1490.
19. FURUTANI, Y., H. NOMURA, M. NOTAKE, Y. OYAMADA, T. FUKUY, M. YAMADA, C. G. LARSEN, J. J. OPPENHEIM, and K. MATSUSHIMA. 1989. Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem. Biophys. Res. Commun. 159: 248.
20. YOSHIMURA, T., N. YUHKI, S. K. MOORE, E. APPELLA, M. I. LERMAN, and E. J. LEONARD. 1989. Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulation blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett. 244: 487.
21. BOTTAZZI, B., F. COLOTTA, A. SICA, N. NOBILI, and A. MANTOVANI. 1990. A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF). Int. J. Cancer 45: 795.
22. SCHALL, T. J. 1994. The cytokine handbook. 2nd ed. A. THOMSON (ed.). Academic Press, London, 419 pp.
23. VAN DAMME, J. 1994. The cytokine handbook. A. THOMSON (ed.). Academic Press, London, 185 pp.
24. YOSHIMURA, T., E. A. ROBINSON, S. TANAKA, E. APPELLA, and E. J. LEONARD. 1989. Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J. Immunol. 142: 1956.
25. VAN DAMME, J., P. PROOST, W. PUT, S. ARENS, J. P. LENAERTS, R. CONINGS, G. OPDENAKKER, H. HEREMANS, and A. BILLIAU. 1994. Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers - Chemical synthesis of MCP-2 and development of a specific RIA. J. Immunol. 152: 5495.
26. COLOTTA, F., A. BORRE, J. M. WANG, M. TATTANELLI, F. MADDALENA, N. POLENTARUTTI, G. PERI, and A. MANTOVANI. 1992. Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes. J. Immunol. 148: 760.
27. COLOTTA, F., F. L. SCIACCA, M. SIRONI, W. LUINI, M. J. RABIET, and A. MANTOVANI. 1994. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am. J. Pathol. 144: 975.
28. SICA, A., J. M. WANG, F. COLOTTA, E. DEJANA, A. MANTOVANI, J. J. OPPENHEIM, C. G. LARSEN, C. O. ZACHARIAE, and K. MATSUSHIMA. 1990. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 144: 3034.
29. LARSEN, C. G., C. O. ZACHARIAE, J. J. OPPENHEIM, and K. MATSUSHIMA. 1989. Production of monocyte chemotactic and activating factor (MCAF) by human dermal fibroblasts in response to interleukin 1 or tumor necrosis factor. Biochem. Biophys. Res. Commun. 160: 1403.
30. ZACHARIAE, C. O., K. THESTRUP PEDERSEN, and K. MATSUSHIMA. 1991. Expression and secretion of leukocyte chemotactic cytokines by normal human melanocytes and melanoma cells. J. Invest. Dermatol. 97: 593.
31. WANG, J. M., A. SICA, G. PERI, S. WALTER, I. M. PADURA, P. LIBBY, M. CESKA, I. LINDLEY, F. COLOTTA, and A. MANTOVANI. 1991. Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells. Arterioscler. Thromb. 11: 1166.
32. ELNER, S. G., R. M. STRIETER, V. M. EINER, B. J. ROLLINS, M. A. DEL MONTE, and S. L. KUNKEL. 1991. Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells. Lab. Invest. 64: 819.
33. JONJIC, N., G. PERI, S. BERNASCONI, F. L. SCIACCA, F. COLOTTA, P. PELICCI, L. LANFRANCONE, and A. MANTOVANI. 1992. Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells. J. Exp. Med. 176: 1165.
34. BROWN, Z., R. M. STRIETER, G. H. NEILD, R. C. THOMPSON, S. L. KUNKEL, and J. WESTWICK. 1992. IL-1 receptor antagonist inhibits monocyte chemotactic peptide 1 generation by human mesangial cells. Kidney. Int. 42: 95.
35. VAN DAMME, J., B. DECOCK, R. BERTINI, R. CONINGS, J. P. LENAERTS, W. PUT, G. OPDENAKKER, and A. MANTOVANI. 1991. Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene. Eur. J. Biochem. 199: 223.
36. CHANG, H. C., F. HSU, G. J. FREEMAN, J. D. GRIFFIN, and E. L. REINHERZ. 1989. Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. Int. Immunol. 1: 388.
37. MINTY, A., P. CHALON, J. C. GUILLEMOT, M. KAGHAD, P. LIAUZUN, M. MAGAZIN, B. MILOUX, C. MINTY, P. RAMOND, N. VITA, J. LUPKER, D. SHIRE, P. FERRARA, and D. CAPUT. 1993. Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. Eur. Cytokine Netw. 4: 99.
38. KULMBURG, P. A., N. E. HUBER, B. J. SCHEER, M. WRANN, and T. BAUMRUKER. 1992. Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells. J. Exp. Med. 176: 1773.
39. OPDENAKKER, G., G. FROYEN, P. FITEN, P. PROOST, and J. VAN DAMME. 1993. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. Biochem. Biophys. Res. Commun. 191: 535.
40. COSTA, J. J., K. MATOSSIAN, M. B. RESNICK, W. J. BEIL, D. T. WONG, J. R. GORDON, A. M. DVORAK, P. F. WELLER, and S. J. GALLI. 1993. Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha. J. Clin. Invest. 91: 2673.
41. COLOTTA, F., M. SIRONI, A. BORRE, W. LUINI, F. MADDALENA, and A. MANTOVANI. 1992. Interleukin 4 amplifies monocyte chemotactic protein and interleukin 6 production by endothelial cells. Cytokine 4: 24.
42. SIRONI, M., C. MUNOZ, T. POLLICINO, A. SIBONI, F. L. SCIACCA, S. BERNASCONI, A. VECCHI, F. COLOTTA, and A. MANTOVANI. 1993. Divergent effects of interleukin-10 on cytokine production by mononuclear phagocytes and endothelial cells. Eur. J. Immunol. 23: 2692.
43. VILLIGER, P. M., R. TERKELTAUB, and M. LOTZ. 1992. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. J. Clin. Invest. 90: 488.
44. ROBINSON, E. A., T. YOSHIMURA, E. J. LEONARD, S. TANAKA, P. R. GRIFFIN, J. SHABANOWITZ, D. F. HUNT, and E. APPELLA. 1989. Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions. Proc. Natl. Acad. Sci. USA 86: 1850.
45. DECOCK, B., R. CONINGS, J. P. LENAERTS, A. BILLIAU, and J. VAN DAMME. 1990. Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form. Biochem. Biophys. Res. Commun. 167: 904.
46. JIANG, Y., A. J. VALENTE, M. J. WILLIAMSON, L. ZHANG, and D. T. GRAVES. 1990. Posttranslational modification of a monocyte-specific chemoattractant synthesized by glioma, osteosarcoma, and vascular smooth muscle cells. J. Biol. Chem. 265: 18318.
47. VAN DAMME, J., P. PROOST, J. P. LENAERTS, and G. OPDENAKKER. 1992. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176: 59.
48. PROOST, P., P. VANLEUVEN, A. WUYTS, R. EBBERINK, G. OPDENAKKER, and J. VAN-DAMME. 1995. Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines. Cytokine 7: 97.
49. OPDENAKKER, G., P. RUDD, M. WORMALD, R. A. DWEK, and J. VAN DAMME. 1995. The glycobiology of cytokines. FASEB. J. 9: 453.
50. ROLLINS, B. J., P. STIER, T. ERNST, and G. G. WONG. 1989. The human homolog of the JE gene encodes as monocyte secretory protein. Mol. Cell Biol. 9: 4687.
51. THIRION, S., G. NYS, P. FITEN, S. MASURE, J. VAN DAMME, and G. OPDENAKKER. 1994. Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC. Biochem. Biophys. Res. Commun. 201: 493.
52. HEINRICH, J. N., R. P. RYSECK, H. MACDONALD-BRAVO, and R. BRAVO. 1993. The product of a novel growth factor-activated gene, fic, is a biologically active C-C-type cytokine. Mol. Cell Biol. 13: 2020.
53. HOLMES, W. E., J. LEE, W. J. KUANG, G. C. RICE, and W. I. WOOD. 1991. Structure and functional expression of a human interleukin-8 receptor. Science 253: 1278.
54. MURPHY, P. M., and H. L. TIFFANY. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253: 1280.
55. GAO, J. L., D. B. KUHNS, H. L. TIFFANY, D. MCDERMOTT, X. LI, U. FRANCKE, and P. M. MURPHY. 1993. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J. Exp. Med. 177: 421.
56. NEOTE, K., D. DIGREGORIO, J. Y. MAK, R. HORUK, and T. J. SCHALL. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72: 415.
57. BEN-BARUCH, A., L. XU, P. R. YOUNG, K. BENGALI, J. J. OPPENHEIM, and J. M. WANG. 1995. Monocyte Chemotactic Protein-3 (MCP-3) Interacts with Multiple Leukocyte Receptors. J. Biol. Chem. 270: 22123.
58. CHARO, I. F., S. J. MYERS, A. HERMAN, C. FRANCI, A. J. CONNOLLY, and S. R. COUGHLIN. 1994. Molecular Cloning and Functional Expression of Two Monocyte Chemoattractant Protein-1 Receptors Reveals Alternative Splicing of the Carboxyl-Terminal Tails. Proc. Natl. Acad. Sci. USA 91: 2752.
59. FRANCI, C., L. M. WONG, J. VAN DAMME, P. PROOST, and I. F. CHARO. 1995. Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. J. Immunol. 154: 6511.
60. COMBADIERE, C., S. AHUJA, and P. M. MURPHY. 1995. Cloning and functional expression of a human eosinophil CC chemokine receptor. J. Biol. Chem. 270: 16491.
61. POWER, C. A., A. MEYER, K. NEMETH, K. B. BACON, A. J. HOOGEWERF, A. E. I. PROUDFOOT, and T. N. C. WELLS. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270: 19495.
62. GAO, J. L., and P. M. MURPHY. 1994. Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor. J. Biol. Chem. 269: 28539.
63. AHUJA, S. K., and P. M. MURPHY. 1993. Molecular piracy of mammalian Interleukin-8 receptor type B by Herpesvirus Saimiri. J. Biol. Chem. 268: 20691.
64. GOODING, L. R. 1992. Virus proteins that counteract host immune defenses. Cell 71: 5.
65. AHUJA, S. K., J. L. GAO, and P. M. MURPHY. 1994. Chemokine receptors and molecular mimicry. Immunol. Today 15: 281.
66. DARBONNE, W. C., G. C. RICE, M. A. MOHLER, T. APPLE, C. A. HEBERT, A. J. VALENTE, and J. B. BAKER. 1991. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J. Clin. Invest. 88: 1362.
67. NEOTE, K., W. DARBONNE, J. OGEZ, R. HORUK, and T. J. SCHALL. 1993. Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells. J. Biol. Chem. 268: 12247.
68. HORUK, R., C. E. CHITNIS, W. C. DARBONNE, T. J. COLBY, A. RYBICKI, T. J. HADLEY, and L. H. MILLER. 1993. A Receptor for the Malarial Parasite Plasmodium vivax - The Erythrocyte Chemokine Receptor. Science 261: 1182.
69. MILLER, M. D., and M. S. KRANGEL. 1992. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit. Rev. Immunol. 12: 17.
70. SOZZANI, S., M. LOCATI, D. ZHOU, M. RIEPPI, W. LUINI, G. LAMORTE, G. BIANCHI, N. POLENTARUTTI, P. ALLAVENA, and A. MANTOVANI. 1995. Receptors, Signal Transduction and Spectrum of Action of Monocyte Chemotactic Protein-1 and Related Chemokines. J. Leukoc. Biol. 57: 788.
71. SOZZANI, S., W. LUINI, M. MOLINO, P. JÍLEK, B. BOTTAZZI, C. CERLETTI, K. MATSUSHIMA, and A. MANTOVANI. 1991. The signal transduction pathway involved in the migration induced by a monocyte chemotactic cytokine. J. Immunol. 147: 2215.
72. MCCOLL, S. R., M. HACHICHA, S. LEVASSEUR, K. NEOTE, and T. J. SCHALL. 1993. Uncoupling of early signal transduction events from effector function in human peripheral blood neutrophils in response to recombinant macrophage inflammatory proteins-1 alpha and -1 beta. J. Immunol. 150: 4550.
73. BISCHOFF, S. C., M. KRIEGER, T. BRUNNER, and C. A. DAHINDEN. 1992. Monocyte chemotactic protein 1 is a potent activator of human basophils. J. Exp. Med. 175: 1271.
74. MYERS, S. J., L. M. WONG, and I. F. CHARO. 1995. Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells. J. Biol. Chem. 270: 5786.
75. SOZZANI, S., M. MOLINO, M. LOCATI, W. LUINI, C. CERLETTI, A. VECCHI, and A. MANTOVANI. 1993. Receptor-activated calcium influx in human monocytes exposed to monocyte chemotactic protein-1 and related cytokines. J. Immunol. 150: 1544.
76. SOZZANI, S., D. ZHOU, M. LOCATI, M. RIEPPI, P. PROOST, M. MAGAZIN, N. VITA, J. VAN DAMME, and A. MANTOVANI. 1994. Receptors and Transduction Pathways for Monocyte Chemotactic Protein-2 and Monocyte Chemotactic Protein-3 - Similarities and Differences with MCP-1. J. Immunol. 152: 3615.
77. MAGHAZACHI, A. A., A. ALAOUKATY, and T. J. SCHALL. 1994. C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells - Role for G proteins. J. Immunol. 153: 4969.
78. LOCATI, M., D. ZHOU, W. LUINI, V. EVANGELISTA, A. MANTOVANI, and S. SOZZANI. 1994. Rapid Induction of Arachidonic Acid Release by Monocyte Chemotactic Protein-1 and Related Chemokines - Role of Ca2+ Influx, Synergism with Platelet-Activating Factor and Significance for Chemotaxis. J. Biol. Chem. 269: 4746.
79. SOZZANI, S., M. RIEPPI, M. LOCATI, D. ZHOU, F. BUSSOLINO, J. VAN DAMME, and A. MANTOVANI. 1994. Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocyte. Biochem. Biophys. Res. Commun. 199: 761.
80. DENNIS, E. A. 1994. Diversity of group types, regulation, and function of phospholipase A2. J. Biol. Chem. 269: 13057.
81. LOCATI, M., G. LAMORTE, W. LUINI, M. INTRONA, S. BERNASCONI, A. MANTOVANI, and S. SOZZANI. 1996. Inhibition of monocyte chemotaxis to C-C chemokines by antisense oligonucleotide for cytosolic phospholipase A(2). J. Biol. Chem. 271: 6010.
82. LUINI, W., S. SOZZANI, J. VAN DAMME, and A. MANTOVANI. 1994. Species-specificity of monocyte chemotactic protein-1 and -3. Cytokine 6: 28.
83. SCHALL, T. J., N. J. SIMPSON, and J. Y. MAK. 1992. Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man. Eur. J. Immunol. 22: 1477.
84. YOSHIMURA, T., and N. YUHKI. 1991. Neutrophil attractant/activation protein-1 and monocyte chemoattractant protein-1 in rabbit. cDNA cloning and their expression in spleen cells. J. Immunol. 146: 3483.
85. ROLLINS, B. J., and M. E. SUNDAY. 1991. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol. Cell Biol. 11: 3125.
86. BOTTAZZI, B., S. WALTER, D. GOVONI, F. COLOTTA, and A. MANTOVANI. 1992. Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J. Immunol. 148: 1280.
87. JIANG, Y., D. I. BELLER, G. FRENDL, and D. T. GRAVES. 1992. Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes. J. Immunol. 148: 2423.
88. VADDI, K., and R. C. NEWTON. 1994. Regulation of monocyte integrin expression by beta-family chemokines. J. Immunol. 153: 4721.
89. MANTOVANI, A., S. SOZZANI, B. BOTTAZZI, G. PERI, F. L. SCIACCA, M. LOCATI, and F. COLOTTA. 1993. Monocyte chemotactic protein-1 (MCP-1): signal transduction and involvement in the regulation of macrophage traffic in normal and neoplastic tissues. Adv. Exp. Med. Biol. 351: 47.
90. OPDENAKKER, G., and J. VAN DAMME. 1992. Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251.
91. GIAVAZZI, R., A. GAROFALO, M. R. BANI, M. ABBATE, P. GHEZZI, D. BORASCHI, A. MANTOVANI, and E. DEJANA. 1990. Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice. Cancer Res. 50: 4771.
92. ROLLINS, B. J., A. WALZ, and M. BAGGIOLINI. 1991. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood 78: 1112.
93. YANO, S., S. SONE, Y. NISHIOKA, N. MUKAIDA, K. MATSUSHIMA, and T. OGURA. 1995. Differential effects of anti-inflammatory cytokines (IL-4, IL-10 and IL-13) on tumoricidal and chemotactic properties of human monocytes induced by monocyte chemotactic and activating factor. J. Leukoc. Biol. 57: 303.
94. SINGH, R. K., K. BERRY, K. MATSUSHIMA, K. YASUMOTO, and I. J. FIDLER. 1993. Synergism Between Human Monocyte Chemotactic and Activating Factor and Bacterial Products for Activation of Tumoricidal Properties in Murine Macrophages. J. Immunol. 151: 2786.
95. ROJAS, A., R. DELGADO, L. GLARIA, and M. PALACIOS. 1993. Monocyte chemotactic protein-1 inhibits the induction of nitric oxide synthase in J774 cells. Biochem. Biophys. Res. Commun. 196: 274.
96. ROT, A., M. KRIEGER, T. BRUNNER, S. C. BISCHOFF, T. J. SCHALL, and C. A. DAHINDEN. 1992. RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176: 1489.
97. LEONARD, E. J., and T. YOSHIMURA. 1990. Human monocyte chemoattractant protein-1 (MCP-1). Immunol. Today 11: 97.
98. BISCHOFF, S. C., M. KRIEGER, T. BRUNNER, A. ROT, V. TSCHARNER, M. BAGGIOLINI, and C. DAHINDEN. 1993. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur. J. Immunol. 23: 761.
99. ALAM, R., P. A. FORSYTHE, M. A. LETT BROWN, and J. A. GRANT. 1992. Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor. Am. J. Respir. Cell Mol. Biol. 7: 427.
100. ALAM, R., M. A. LETT BROWN, P. A. FORSYTHE, D. J. ANDERSON WALTERS, C. KENAMORE, C. KORMOS, and J. A. GRANT. 1992. Monocyte chemotactic and activating factor is a potent histamine-relcasing factor for basophils. J. Clin. Invest. 89: 723.
101. KUNA, P., S. R. REDDIGARI, D. RUCINSKI, J. J. OPPENHEIM, and A. P. KAPLAN. 1992. Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils. J. Exp. Med. 175: 489.
102. NOSO, N., P. PROOST, J. VAN DAMME, and J. M. SCHRODER. 1994. Human monocyte chemotactic proteins-2 and -3 (MCP-2 and MCP-3) attract human eosinophils and desensitize the chemotactic responses towards RANTES. Biochem. Biophys. Res. Commun. 200: 1470.
103. ALAM, R., P. FORSYTHE, S. STAFFORD, J. HEINRICH, R. BRAVO, P. PROOST, and J. VAN DAMME. 1994. Monocyte chemotactic protein-2, monocyte chemotactic protein-3, and fibroblast-induced cytokine - Three new chemokines induce chemotaxis and activation of basophils. J. Immunol. 153: 3155.
104. DAHINDEN, C. A., T. GEISER, T. BRUNNER, V. VONTSCHARNER, D. CAPUT, P. FERRARA, A. MINTY, and M. BAGGIOLINI. 1994. Monocyte Chemotactic Protein 3 Is a Most Effective Basophil- and Eosinophil-Activating Chemokine. J. Exp. Med. 179: 751.
105. LOETSCHER, P., M. SEITZ, I. CLARKLEWIS, M. BAGGIOLINI, and B. MOSER. 1994. Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4(+) and CD8(+) T lymphocytes. FASEB. J. 8: 1055.
106. TAUB, D. D., P. PROOST, W. J. MURPHY, M. ANVER, D. L. LONGO, J. VAN DAMME, and J. J. OPPENHEIM. 1995. Monocyte chemotactic protein-1 (MCP-1),-2, and -3 are chemotactic for human T lymphocytes. J. Clin. Invest. 95: 1370.
107. CARR, M. W., S. J. ROTH, E. LUTHER, S. S. ROSE, and T. A. SPRINGER. 1994. Monocyte Chemoattractant Protein 1 Acts as a T-Lymphocyte Chemoattractant. Proc. Natl. Acad. Sci. USA 91: 3652.
108. ALLAVENA, P., G. BIANCHI, D. ZHOU, J. VAN DAMME, P. JÌLEK, S. SOZZANI, and A. MANTOVANI. 1994. Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. Eur. J. Immunol. 24: 3233.
109. ALLAVENA, P., G. BIANCHI, P. GIARDINA, N. POLENTARUTTI, D. ZHOU, M. INTRONA, S. SOZZANI, and A. MANTOVANI. 1995. Migratory Response of Human NK Cells to Monocyte-chemotactic Proteins. Methods (in press).
110. SOZZANI, S., F. SALLUSTO, W. LUINI, D. ZHOU, L. PIEMONTI, P. ALLAVENA, J. VAN DAMME, S. VALITUTTI, A. LANZAVECCHIA, and A. MANTOVANI. 1995. Migration of dendritic cells in response to formyl peptides, C5a and a distinct set of chemokines. J. Immunol. 155: 3292.
111. OPDENAKKER, G., and J. VAN DAMME. 1992. Chemotactic factors, passive invasion and metastasis of cancer cells. Immunol. Today 13: 463.
112. WALTER, S., B. BOTTAZZI, D. GOVONI, F. COLOTTA, and A. MANTOVANI. 1991. Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE. Int. J. Cancer 49: 431.
113. MANTOVANI, A., B. BOTTAZZI, S. SOZZANI, G. PERI, P. ALLAVENA, Q. G. DONG, A. VECCHI, and F. COLOTTA. 1993. Cytokine regulation of tumour-associated macrophages. Res. Immunol. 144: 280.
114. SONOUCHI, K., T. A. HAMILTON, C. S. TANNENBAUM, R. R. TUBBS, R. BUKOWSKI, and J. H. FINKE. 1994. Chemokine Gene Expression in the Murine Renal Cell Carcinoma, Renca, Following Treatment in Vivo with Interferon-alpha and Interleukin-2. Am. J. Pathol. 144: 747.
115. GRAVES, D. T., R. BARNHILL, T. GALANOPOULOS, and H. N. ANTONIADES. 1992. Expression of monocyte chemotactic protein-1 in human melanoma in vivo. Am. J. Pathol. 140: 9.
116. TAKEYA, M., T. YOSHIMURA, E. J. LEONARD, T. KATO, H. OKABE, and K. TAKAHASHI. 1991. Production of monocyte Chemoattractant protein-1 by malignant fibrous histiocytoma: relation to the origin of histiocyte-like cells. Exp. Mol. Pathol. 54: 61.
117. SCIACCA, F. L., M. STÜRZL, F. BUSSOLINO, M. SIRONI, H. BRANDSTETTER, C. ZIETZ, D. ZHOU, C. MATTEUCCI, G. PERI, S. SOZZANI, R. BENELLI, M. ARESE, A. ALBINI, F. COLOTTA, and A. MANTOVANI. 1994. Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells. J. Immunol. 153: 4816.
118. PERI, G., C. MILANESE, C. MATTEUCCI, L. RUCO, D. ZHOU, S. SOZZANI, I. COLETTA, and A. MANTOVANI. 1994. A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells. J. Immunol. Methods 174: 249.
119. NEGUS, R. P., G. W. STAMP, M. G. RELF, F. BURKE, S. T. MALIK, S. BERNASCONI, P. ALLAVENA, S. SOZZANI, A. MANTOVANI, and F. R. BALKWILL. 1995. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin. Invest. 95: 2391.
120. MANTOVANI, A. 1994. Tumor-associated macrophages in neoplastic progression: A paradigm for the in vivo function of chemokines. Lab. Invest. 71: 5.
121. SNYDERMAN, R., and G. CIANCIOLO. 1984. Immunosuppressive activity of the retroviral envelope protein P15E and its possible relationship to neoplasia. Immunol. Today 5: 240.
122. COLOTTA, F., S. ORLANDO, E. J. FADLON, S. SOZZANI, C. MATTEUCCI, and A. MANTOVANI. 1995. Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells. J. Exp. Med. 181: 2181.
123. PORTEU, F., and C. NATHAN. 1990. Shedding of tumor necrosis factor receptor by activated human neutrophils. J. Exp. Med. 172: 599.
124. YU, X., S. DLUZ, D. T. GRAVES, L. ZHANG, H. N. ANTONIADES, W. HOLLANDER, S. PRUSTY, A. J. VALENTE, C. J. SCHWARTZ, and G. E. SONENSHEIN. 1992. Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates. Proc. Natl. Acad. Sci. USA 89: 6953.
125. TAKEYA, M., T. YOSHIMURA, E. J. LEONARD, and K. TAKAHASHI. 1993. Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an antimonocyte chemoattractant protein-1 monoclonal antibody. Hum. Pathol. 24: 534.
126. YLA HERTTUALA, S., B. A. LIPTON, M. E. ROSENFELD, T. SARKIOJA, T. YOSHIMURA, E. J. LEONARD, J. L. WITZTUM, and D. STEINBERG. 1991. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl. Acad. SCi. USA 88: 5252.
127. NELKEN, N. A., S. R. COUGHLIN, D. GORDON, and J. N. WILCOX. 1991. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88: 1121.
128. RUSSELL, M. E., D. H. ADAMS, L. R. WYNER, Y. YAMASHITA, N. J. HALNON, and M. J. KARNOVSKY. 1993. Early and Persistent Induction of Monocyte Chemoattractant Protein-1 in Rat Cardiac Allografts. Proc. Natl. Acad. Sci. USA 90: 6086.
129. RANSOHOFF, R. M., T. A. HAMILTON, M. TANI, M. H. STOLER, H. E. SHICK, J. A. MAJOR, M. L. ESTES, D. M. THOMAS, and V. K. TUOHY. 1993. Astrocyte Expression of Messenger RNA Encoding Cytokines IP-10 and JE/MCP-1 in Experimental Autoimmune Encephalomyelitis. FASEB. J. 7: 592.
130. ZHANG, K., M. GHARAEEKERMANI, M. L. JONES, J. S. WARREN, and S. H. PHAN. 1994. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol. 153: 4733.
131. SAKANASHI, Y., M. TAKEYA, T. YOSHIMURA, L. FENG, T. MORIOKA, and K. TAKAHASHI. 1994. Kinetics of macrophage subpopulations and expression of monocyte chemoattractant protein-1 (MCP-1) in bleomycin-induced lung injury of rats studied by a novel monoclonal antibody against rat MCP-1. J. Leukoc. Biol. 56: 741.
132. JONES, M. L., M. S. MULLIGAN, C. M. FLORY, P. A. WARD, and J. S. WARREN. 1992. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. J. Immunol. 149: 2147.
133. FLORY, C. M., M. L. JONES, and J. S. WARREN. 1993. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein-1. Lab. Invest. 69: 396.
134. POON, M., J. MEGYESI, R. S. GREEN, H. ZHANG, B. J. ROLLINS, R. SAFIRSTEIN, and M. B. TAUBMAN. 1991. In vivo and in vitro inhibition of JE gene expression by glucocorticoids. J. Biol. Chem. 266: 22375.
135. JANSEN, P. M., J. VAN DAMME, W. PUT, I. W. DE JONG, F. B. JR. TAYLOR, and E. C. HACK, 1995. Monocyte Chemotactic Protein 1 is Released During Lethal and Sublethal Bacteremia in Baboons. J. Infect. Dis. 171: 1640.
136. ROVIN, B. H., M. RUMANCIK, L. TAN, and J. DICKERSON. 1994. Glomerular expression of monocyte chemoattractant protein-1 in experimental and human glomerulonephritis. Lab. Invest. 71: 536.
137. ANTONIADES, H. N., J. NEVILLE GOLDEN, T. GALANOPOULOS, R. L. KRADIN, A. J. VALENTE, and D. T. GRAVES. 1992. Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis. Proc. Natl. Acad. Sci. USA 89: 5371.
138. MARRA, F., A. J. VALENTE, M. PINZANI, and H. E. ABBOUD. 1993. Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. J. Clin. Invest. 92: 1674.
139. CZAJA, M. J., A. GEERTS, J. XU, P. SCHMIEDEBERG, and Y. JU. 1994. Monocyte Chemoattractant Protein 1 (MCP-1) Expression Occurs in Toxic Rat Liver Injury and Human Liver Disease. J. Leukoc. Biol. 55: 120.
140. YU, X., R. L. BARNHILL, and D. T. GRAVES. 1994. Expression of Monocyte Chemoattractant Protein-1 in Delayed Type Hypersensitivity Reactions in the Skin. Lab. Invest. 71: 226.
141. KOCH, A. E., S. L. KUNKEL, L. A. HARLOW, B. JOHNSON, H. L. EVANOFF, G. K. HAINES, M. D. BURDICK, R. M. POPE, and R. M. STRIETER. 1992. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90: 772.
142. VILLIGER, P. M., R. TERKELTAUB, and M. LOTZ. 1992. Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes. J. Immunol. 149: 722.
143. HACHICHA, M., P. RATHANASWAMI, T. J. SCHALL, and S. R. MCCOLL. 1993. Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor alpha and interferon-gamma. Arthritis Rheum. 36: 26.
144. SYLVESTER, I., A. F. SUFFREDINI, A. J. BOUJOUKOS, G. D. MARTICH, R. L. DANNER, T. YOSHIMURA, and E. J. LEONARD. 1993. Neutrophil attractant protein-1 and monocyte chemoattractant protein-1 in human serum. Effects of intravenous lipopolysaccharide on free attractants, specific IgG autoantibodies and immune complexes. J. Immunol. 151: 3292.
145. YOSHIMURA, T., M. TAKEYA, K. TAKAHASHI, J. KURATSU, and E. J. LEONARD. 1991. Production and characterization of mouse monoclonal antibodies against human monocyte chemoattractant protein-1. J. Immunol. 147: 2229.
146. CHENSUE, S. W., K. S. WARMINGTON, N. W. LUKACS, P. M. LINCOLN, M. D. BURDICK, R. M. STRIETER, and S. L. KUNKEL. 1995. Monocyte chemotactic protein expression during schistosome egg granuloma formation: Sequence of production, localization, contribution, and regulation. Am. J. Pathol. 146: 130.
147. ZIPFEL, P. F., A. BIALONSKI, and C. SKERKA. 1991. Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A. Biochem. Biophys. Res. Commun. 181: 179.
148. MUKAIDA, N., G. L. GUSSELLA, T. KASAHARA, Y. KO, C. O. ZACHARIAE, T. KAWAI, and K. MATSUSHIMA. 1992. Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. Immunology 75: 674.
149. WERTHEIM, W. A., S. L. KUNKEL, T. J. STANDIFORD, M. D. BURDICK, F. S. BECKER, C. A. WILKE, A. R. GILBERT, and R. M. STRIETER. 1993. Regulation of neutrophil-derived IL-8: the role of prostaglandin E2, dexamethasone, and IL-4. J. Immunol. 151: 2166.
150. MUKAIDA, N., M. MORITA, Y. ISHIKAWA, N. RICE, S. OKAMOTO, T. KASAHARA, and K. MATSUSHIMA. 1994. Novel mechanism of glucocorticoid-mediated gene repression. J. Biol. Chem. 269: 13289.
151. LOETSCHER, P., B. DEWALD, M. BAGGIOLINI, and M. SEITZ. 1994. Monocyte Chemoattractant Protein 1 and Interleukin 8 production by Rheumatoid Synoviocytes - Effects of Anti-Rheumatic Drugs. Cytokine 6: 162.
152. SEKIDO, N., N. MUKAIDA, A. HARADA, I. NAKANISHI, Y. WATANABE, and K. MATSUSHIMA. 1993. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 365: 654.
153. BROADDUS, C. V., A. M. BOYLAN, J. K. HOEFFEL, J. K. KIM, M. SADIK, A.
154. ZHANG, Y. J., B. J. RUTLEDGE, and B. J. ROLLINS. 1994. Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis - Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis. J. Biol. Chem. 269: 15918.
155. GONG, J. H., and I. CLARKLEWIS. 1995. Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues. J. Exp. Med. 181: 631.
156. MAZE, R., B. SHERRY, B. S. KWON, A. CERAMI, and H. E. BROXMEYER. 1992. Myelosuppressive effects in vivo of purified recombinant murine macrophage inflammatory protein-1 alpha. J. Immunol. 149: 1004.
157. DUNLOP, D. J., E. G. WRIGHT, S. LORIMORE, G. J. GRAHAM, T. HOLYOAKE, D. J. KERR, S. D. WOLPE, and I. B. PRAGNELL. 1992. Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo. Blood 79: 2221.
158. LORD, B. I., L. B. WOOLFORD, L. M. WOOD, L. G. CZAPLEWSKI, M. MCCOURT, M. G. HUNTER, and R. M. EDWARDS. 1995. Mobilization of early hematopoietic progenitor cells with BB-10010: a genetically engineered variant of human macrophage inflammatory protein-1 alpha. Blood 85: 3412.
159. UGUCCIONI, M., M. DAPUZZO, M. LOETSCHER, B. DEWALD, and M. BAGGIOLINI. 1995. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. Eur. J. Immunol. 25: 64.
160. ALAM, R., P. A. FORSYTHE, S. STAFFORD, M. A. LETT BROWN, and J. A. GRANT. 1992. Macrophage inflammatory protein-1 alpha activates basophils and mast cells. J. Exp. Med. 176: 781.
161. MORITA, M., T. KASAHARA, N. MUKAIDA, K. MATSUSHIMA, T. NAGASHIMA, M. NISHIZAWA, and M. YOSHIDA. 1993. Induction and Regulation of IL-8 and MCAF Production In Human Brain Tumor Cell Lines and Brain Tumor Tissues. Eur. Cytokine Netw. 4: 351.
162. IYONAGA, K., M. TAKEYA, N. SAITA, O. SAKAMOTO, T. YOSHIMURA, M. ANDO, and K. TAKAHASHI. 1994. Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other interstitial lung diseases. Hum. Pathol. 25: 455.
163. MOSER, B., B. DEWALD, L. BARELLA, C. SCHUMACHER, M. BAGGIOLINI, and I. CLARK LEWIS. 1993. Interleukin-8 antagonists generated by N-terminal modification. J. Biol. Chem. 268: 7125.