Hepatic insulin removal following oral glucose loading in non-obese subjects with glucose intolerance and mild type II diabetes

Endocrinology and Metabolism, Supplement

Volumn 3, Issue 4, 1996, Pages 265-274

  Wasilewska, Mira ^a   Pye, Susan ^a   Braaten, Jan ^a   Chen, Mina ^a   Radziuk, Jerry ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN METABOLISM; INSULIN RELEASE; INSULIN SENSITIVITY; LIVER METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0029828728     PISSN: 1074939X     EISSN: 20935978     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of Type II diabetes in the offspring of diabetic parents. Ann. Intern. Med. 1990; 113: 909-915.
2. Zimmet PZ, Collins VR, Dowse GK, Knight LT. Hyperinsulinemia in youth is a predictor of Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992; 35: 534-541.
3. Niskanen LK, Uusitupa MI, Sarlund H, Siitonen O, Pyorala K. Five-year follow-up study on plasma insulin levels in newly diagnosed NIDDM patients and nondiabetic subjects. Diabetes Care 1990; 13: 41-48.
4. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A, Fuchs Z. Hyperinsulinemia: A link between hypertension obesity and glucose intolerance. J. Clin. Invest. 1985; 75: 809-817.
5. Reaven GM. Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease. Am. Heart J. 1991; 121: 1283-1288.
6. Stout RW. Insulin as a mitogenic factor: role in the pathogenesis of cardiovascular disease. Am. J. Med. 1991; 90 (Suppl 2A): 625-645.
7. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
8. Nankervis A, Proietto J, Aitken P, Alford F. Hyperinsulinemia and insulin insensitivity: studies in subjects with insulinoma. Diabetologia 1985; 28: 427-431.
9. Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE. Production of insulin resistance by hyperinsulinemia in man. Diabetologia 1985; 28: 70-75.
10. Leahy JL, Weir GC. Beta-cell dysfunction in hyperglycemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia 1991; 34: 640-647.
11. Ostenson CG, Pigon J, Radziuk J, Efendic S. Different mechanisms of low insulin response in prediabetic and endurance-trained subjects. Diabetologia 1992; 35: A108.
12. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH. Splanchnic insulin metabolism in obesity: influence of body fat distribution. J. Clin. Invest. 1986; 78: 1648-1657.
13. Svedberg J, Strömglad G, Wirth A, Smith U, Björntrop P. Fatty acids in the portal vein of the rate regulate hepatic insulin clearance. J. Clin. Invest. 1991; 88: 2054-2058.
14. Halban PA, Offord RE. The preparation of semisynthetic tritiated insulin with a specific radioactivity of up to 20 Curies per millimole. Biochem. J. 1975; 151: 219-225.
15. Morishima T, Pye S, Polonsky K, Radziuk J. The measurement and validation of nonsteady-state rates of C-peptide appearance in the dog. Diabetologia 1986; 29(7): 440-446.
16. Pye S, Watarai T, Davies G, Radziuk J. Comparison of the continuously calculated fractional hepatic extraction of insulin with its fractional extraction using a new double tracer technique. Metabolism 1993; 42: 145-153.
17. Radziuk J, Morishima T. Assessment of insulin kinetics in vivo. In: J. Larner ed. Methods in Diabetes Research, Vol. I: Clinical Methods, New York: Academic Press; 1986: 91-106.
18. Rossetti L, Giaccari T, DeFronzo RA. Glucose toxicity. Diabetes Care 1990; 13: 610-630.
19. Keen H. Limitations and problems of diabetes classification from an epidemiological point of view. Adv. Exp. Med. Biol. 1985; 189: 31-46.
20. Faber OK, Christensen K, Kehlet H, Madsbad S, Binder C. Decreased insulin removal contributesto hyperinsulinemia in obesity. J. Clin. Endoc. Metabol. 1981; 53: 618-621.
21. Field JB. Extraction of insulin by the liver. Am. Rev. Med. 1973; 309-314.
22. Ferrannini E, Cobelli C. The kinetics of insulin in man. II. Role of the liver. Diabetes Metabol. Rev. 1987; 3: 365-397.
23. Morishima T, Bradshaw C, Radziuk J. Measurement using tracers of steady-state turnover and metabolic clearance of insulin in dogs. Am. J. Physiol. 1985; 248 (Endocrinol. Metab. 11): E203-E208.
24. Morishima T, Pye S, Bradshaw C, Radziuk J. Post-hepatic rate of appearance of insulin: Measurement and validation under non-steady state conditions. Am. J. Physiol. 1992; 263: E772-779.
25. Sönksen PH, Tomkins CV, Srivastava MC, Nabarro JDN. A comparative study on the metabolism of human insulin and porcine proinsulin in man. Clin. Sci. Mol. Med. 1973; 45: 633-654.
26. Kaden M, Harding P, Field JB. Effect of intraduodenal glucose administration on hepatic extraction of insulin in the anesthetized dog. J. Clin. Invest. 1971; 52: 2016-2028.
27. Waldhausl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P. Insulin production rate following glucose ingestion estimated by splanchnic C-Peptide output in normal man. Diabetologia 1979; 17: 221-227.
28. Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes. J. Clin. Endocrinol. Metabol. 1991; 72: 96-107.
29. Svedberg J, Strömglad G, Wirth A, Smith U, Björntrop P. Fatty acids in the portal vein of the rate regulate hepatic insulin clearance. J. Clin. Invest. 1991; 88: 2054-2058.
30. Hennes MMI, Shrago E, Kissebah AH. Receptor and post-receptor effects of free fatty acids (FFA) in hepatocyte insulin dynamics. Int. J. Obesity 1990; 14: 831-841.
31. Goldstein BJ, Livingston JN. Insulin degradation by insulin target cells. Metabolism 1981; 30: 825-835.
32. Häring HU. The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance. Diabetologia 1991; 34: 848-861.
33. Petrides AS, DeFronzo RA. Glucose and insulin metabolism in cirrhosis. J. Hepatol. 1989; 8: 107-114.
34. Kruszynska Y, Home PD, McIntrye N. Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis. Hepatology 1991; 14: 103-111.
35. Radziuk J, Barron P, Najm H, Davies J. The effect of systemic drainage of the pancreas on insulin sensitivity in dogs. J. Clin. Invest. 1993; 92: 1713-1721.
36. Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ, Hales CN. Insulin deficiency in non-insulin-dependent diabetes. The Lancet 1989; Feb. 11: 293-297.
37. Levy JC, Clark PM, Hales CN, Turner RC. Normal proinsulin responses to glucose in mild Type II subjects with sub-normal insulin response. Diabetes 1993; 42: 162-169.
38. Bonora E, Zavaroni I, Coscelli C, Butturini U. Decreased hepatic insulin extraction in subjects with mild glucose intolerance. Metabolism 1983; 32: 438-446.
39. Madsbad S, Kehlet H, Hilsted J, Tronier B. Discrepancy between plasma C-peptide and insulin response to oral and intravenous glucose. Diabetes 1983; 32: 436-438.
40. Polonsky KS, Rubenstein AH. C-peptide as a measure of the secretion and hepatic extraction of insulin - Pitfalls and limitations. Diabetes 1984; 33: 486-494.