Highly conserved toxicity of Saccharomyces cerevisiae Rap1p

Molecular Microbiology

Volumn 22, Issue 3, 1996, Pages 449-458

  Chambers, Alistair ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; DNA BINDING; FUNGUS GROWTH; GENE EXPRESSION REGULATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; TELOMERE; TOXICITY TESTING; TRANSCRIPTION REGULATION;

FUNGI; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0029828155     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.00134.x     Document Type: Article

References (37)

1. Brindle, P.K., Holland, J.P., Willett, C.E., Innis, M.A., and Holland., M.J. (1990) Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABF1 protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. Mol Cell Biol 10: 4872-4885.
2. Buck, S.W., and Shore, D. (1995) Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Genes Dev 9: 370-384.
3. Chambers, A., Tsang, J.H., Stanway, C., Kingsman, A.J., and Kingsman, S.M. (1989) Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1. Mol Cell Biol 9: 5516-5524.
4. Cockell, M., Palladino, F., Laroche, T., Kyrion, G., Liu, C., Lustig, A.J., and Gasser, S.M. (1995) The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol 129: 909-924.
5. Conrad, M.N., Wright, J.H., Wolf, A.J., and Zakian, V.A. (1990) RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63: 739-750.
6. Duffy, M., and Chambers, A. (1996) DNA - protein interactions at the telomeric repeats of Schizosaccharomyces pombe. Nucl Acids Res 24: 1412-1419.
7. Freeman, K., Gwadz, M., and Shore, D. (1995) Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast. Genetics 141: 1253-1262.
8. Gilson, E., Roberge, M., Giraldo, R., Rhodes, D., and Gasser, S.M. (1993) Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J Mol Biol 231: 293-310.
9. Giraldo, R., and Rhodes, D. (1994) The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA. EMBO J 13: 2411-2420.
10. Giraldo, R., Suzuki, M., Chapman, L., and Rhodes, D. (1994) Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study. Proc Natl Acad Sci USA 91: 7658-7662.
11. Graham, I.R., and Chambers., A. (1994) A Reb1p-binding site is required for efficient activation of the yeast RAP1 gene, but multiple binding sites for Rap1p are not essential. Mol Microbiol 12: 931-940.
12. Hardy, C.F.J., Balderes, D., and Shore, D. (1992a) Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing. Mol Cell Biol 12: 1209-1217.
13. Hardy, C.F.J., Sussel, L., and Shore, D. (1992b) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6: 801-814.
14. Hawthorne, D.C., and Mortimer., R.K. (1960) Chromosome mapping in Saccharomyces cerevisiae: centromere-linked genes. Genetics 45: 1085-1110.
15. Hecht, A., Laroche, T., Strahl-Bolsinger, S., Gasser, S.M., and Grunstein, M. (1995) Histone H3 and H4 N-termini interact with SIRS and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592.
16. Henry, Y.A.L., Chambers, A., Tsang, J.S.H., Kingsman, A.J., and Kingsman, S.M. (1990) Characterisation of the DNA-binding domain of the yeast RAP1 protein. Nucl Acids Res 18: 2617-2623.
17. Hoffman, C.S., and Winston, F. (1989) A transcriptionally regulated expression vector for the fission yeast Schizosaccharomyces pombe. Gene 84: 473-479.
18. Huet, J., Cottrelle, P., Cool, M., Vignais, M.L., Thiele, D., Marck, C., Buhler, J.M., Sentenac, A., and Fromageot, P. (1985) A general upstream binding factor for genes of the yeast translational apparatus. EMBO J 4: 3539-3547.
19. Ito, H., Fukada, Y., Murata, K., and Kimura., A. (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168.
20. Konig, P., Giraldo, R., Chapman, L., and Rhodes, D. (1996) The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell 85: 125-136.
21. Kurtz, S., and Shore, D. (1991) RAP1 protein activates and silences transcription of mating-type genes in yeast. Genes Dev 5: 616-628.
22. Kyrion, G., Boakye, K.A., and Lustig, A.J. (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol 12: 5159-5173.
23. Liu, C., Mao, X., and Lustig, A.J. (1994) Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae. Genetics 138: 1025-1040.
24. Longtine, M.S., Wilson, N.M., Petracek, M.E., and Berman, J. (1989) A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1. Curr Genet 16: 225-239.
25. Lustig, A.J., Kurtz, S., and Shore., D. (1990) Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250: 549-553.
26. Meisels, E., Gileadi, O., and Corden, J.L (1995) Partial truncation of the yeast RNA polymerase II carboxyl-terminal domain preferentially reduces expression of glycolytic genes. J Biol Chem 270: 31255-31261.
27. Moretti, P., Freeman, K., Coodly, L., and Shore, D. (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere binding protein RAP1. Genes Dev 8: 2257-2269.
28. Nishizawa, M., Araki, R., and Teranishi, Y. (1989) Identification of an upstream activating sequence and an upstream repressible sequence of the pyruvate kinase gene of the yeast Saccharomyces cerevisiae. Mol Cell Biol 9: 442-451.
29. Nishizawa, M., Suzuki, Y., Nogi, Y., Matsumoto, K., and Fukasawa, T. (1990) Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/ activator site binding protein1/translation upstream factor. Proc Natl Acad Sci USA 87: 5373-5377.
30. Ogden, J.E., Stanway, C., Kim, S., Mellor, J., Kingsman, A.J., and Kingsman, S.M. (1986) Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activating sequence, but does not require TATA sequences. Mol Cell Biol 6: 4335-4343.
31. Shore, D. (1994) RAP1: a protean regulator in yeast. Trends Genet 10: 408-412.
32. Shore, D., and Nasmyth., K. (1987) Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51: 721-732.
33. Shore, D., Stillman, D.J., Brand, A.H., and Nasmyth, K.A. (1987) Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication. EMBO J 6: 461-467.
34. Sugawara, N. (1989) DNA sequences at the telomeres of the fission yeast S pombe. PhD thesis, Harvard University, Cambridge, Massachusetts, USA.
35. Sussel, L., and Shore., D. (1991) Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc Natl Acad Sci USA 88: 7749-7753.
36. Wellinger, R.J., Wolf, A.J., and Zakian, V.A. (1993) Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72: 51-60.
37. Woudt, L.P., Mager, W.H., Nieuwint, R.T.M., Wassenaar, G.M., van der Kuyl, A.C., Murre, J.J., Hoekman, M.P.M., Brockhoff, P.G.M., and Planta, R.J. (1987) Analysis of upstream activation sites of yeast ribosomal protein genes. Nucl Acids Res 15: 6037-6048.