Comparable potent coronary constrictor effects of endothelin-1 and big endothelin-1 in humans

Circulation

Volumn 94, Issue 9, 1996, Pages 2077-2082

  Pernow, John ^a   Kaijser, Lennart ^a   Lundberg, Jan M ^b   Ahlborg, Gunvor ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

blood flow; endothelin; hemodynamics; oxygen; vasoconstriction

Indexed keywords

ENDOTHELIN 1; PROTEIN PRECURSOR;

ADULT; ARTICLE; BLOOD LEVEL; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; CORONARY HEMODYNAMICS; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 0029827820     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.9.2077     Document Type: Article

References (32)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
2. Opgenorth TJ, Wu-Wong JR, Shiosaki K. Endothelin-converting enzymes. FASEB J. 1992;6:2653-2659.
3. Turner AJ, Murphy LJ. Molecular pharmacology of endothelin converting enzymes. Biochem Pharmacol. 1996;51:91-102.
4. Arai S, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730-732.
5. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature. 1990;348:732-735.
6. Weitzberg E, Rudehill A, Modin A, Lundberg JM. Porcine intrinsic pulmonary and systemic vascular tone is endothelin dependent. Acta Physiol Scand. 1994;152:433-434.
7. Teerlink JR, Carteaux J-P, Sprecher U, Löffler B-M, Clozel M, Clozel J-P. Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs. Am J Physiol. 1995;268:H432-H440.
8. Vierhapper H, Wagner O, Nowotny P, Waldhäusl W. Effect of endothelin-1 in man. Circulation. 1990;81:1415-1418.
9. Weitzberg E, Ahlborg G, Lundberg JM, Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues. Biochem Biophys Res Commun. 1991;180:1298-1303.
10. Gasic S, Wagner OF, Vierhapper H, Nowotny P, Waldhäusi W. Regional hemodynamic effects and clearance of endothelin-1 in humans: renal and peripheral tissues may contribute to the overall disposal of the peptide. J Cardiovasc Pharmacol 1992;19:176-180.
11. Pernow J, Hemsén A, Lundberg JM, Nowak J, Kaijser L. Potent vasoconstrictor effects and clearance of endothelin in the human forearm. Acta Physiol Scand. 1991;141:319-324.
12. Weitzberg E, Ahlborg G, Lundberg JM. Differences in vascular effects and removal of endothelin-1 in human lung, brain, and skeletal muscle. Clin Physiol. 1993;13:653-662.
13. Hemsén A, Franco-Cereceda A, Matran R, Rudehill A, Lundberg JM. Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue. Eur J Pharmacol. 1990;191: 319-328.
14. Hemsén A, Ahlborg G, Ottosson-Seeberger A, Lundberg JM. Metabolism of big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1. Regul Pept. 1995;55:287-297.
15. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev. 1994;46:325-415.
16. Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994;2:852-854.
17. Bax WA, Aghai Z, van Tricht CLJ, Wassenaar C, Saxena PR. Different endothelin receptors involved in endothelin-1- and sarafotoxin S6B-induced contractions of human isolated coronary arteries. Br J Pharmacol. 1994;113:1471-1479.
18. Ahlborg G, Ottosson-Seeberger A, Hemsén A, Lundberg JM. Big ET-1 infusion in man causes renal ET-1 release, renal and splanchnic vasoconstriction, and increased mean arterial blood pressure. Cardiovasc Res. 1994;28:1559-1563.
19. Miyauchi T, Yanagisawa M, Tomizawa T. Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet. 1989;2:53-54.
20. Wieczorek I, Haynes WG, Webb DJ, Ludlam CA, Fox KAA. Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome. Br Heart J. 1994;72:436-441.
21. Lerman A, Edwards BS, Hallett JW, Heublein D, Sandberg SM, Burnett JC. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med. 1991;325:997-1001.
22. Tomoda H. Plasma endothelin-1 in acute myocardial infarction with heart failure. Am Heart J. 1993;125:667-672.
23. Wang Q-D, Li X-S, Lundberg JM, Pernow J. Protective effect of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig. Cardiovasc Res. 1995;29:805-812.
24. Gantz WK, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJC. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation. 1971;44:181-195.
25. Kaijser L, Berglund B. Effect of nicotine on coronary blood flow in man. Clin Physiol. 1985;5:541-552.
26. Hemsén A, Larsson O, Lundberg JM. Characteristics of endothelin A and B binding sites and their vascular effects in pig peripheral tissues. Eur J Pharmacol. 1991;208:313-322.
27. Kashiwabara T, Inagaki Y, Ohta H, Iwamatsu A, Nomizu M, Monta A, Nishikori K. Putative precursors of endothelin have less vasoconstrictor activity in vitro but potent pressor effects in vivo. FEBS Lett. 1989;247:73-76.
28. Ikegawa R, Matsumura Y, Tsukahara Y, Takaoka M, Morimoto S. Phosphoramidon inhibits the generation of endothelin 1 from exogenously applied big endothelin 1 in cultured vascular endothelial cells and smooth muscle cells. FEBS Lett. 1991;293:45-48.
29. Matsumura Y, Ikegawa R, Tsukahara Y, Takaoka M, Morimoto S. Conversion of big endothelin 1 to endothelin 1 by two types of metalloproteinases of cultured porcine vascular smooth muscle cells. Biochem Biophys Res Commun. 1991;178:899-905.
30. Davenport AP, Oreilly G, Kuc RE. Endothelin ET(a) and ET(b) mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ET(a) sub-type. Br J Pharmacol. 1995;114:1110-1116.
31. Fukuroda T, Noguchi K, Tsuchida S, Nishikibe M, Ikemoto F, Okada K, Yano M. Inhibition of biological actions of big endothelin 1 by phosphoramidon. Biochem Biophys Res Commun. 1990;172: 390-395.
32. Weitzberg E, Lundberg JM, Rudehill A. Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ Shock. 1991;33: 222-227.