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(b) Danishefsky, S. Science 1993, 259, 469 and references therein,
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20
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-
10244220140
-
-
note
-
The theoretical catalyst, or theoretical enzyme, has been nicknamed a "theozyme".
-
-
-
-
21
-
-
10244278268
-
-
note
-
Calculations on both five-membered complexes for more than 200 optcycles produce the complexes shown. After the first 100 steps, the optimizations showed an oscillating pattern between optcycles, but no real change in structure or energy occurs. Both six-membered complexes are energy-minimized structures.
-
-
-
-
22
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0000592263
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Coxon, J. M.; Hartshorn, M. P.; Swallow, W. H. Aust. J. Chem. 1973, 26, 2521.
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Swallow, W.H.3
-
23
-
-
10244239611
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-
note
-
N1 character for the endo opening was found to be true for the cis case also, as well as the cis and trans 4-exo- vs 5-endoepoxide openings.
-
-
-
-
24
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0001195079
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Cycloheptane is 6 kcal/mol more strained than cyclohexane: Engler, E. M.; Andose, J. D.; Schleyer, P. v. R. J. Am. Chem. Soc. 1973, 95, 8005.
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