Inhibition of 2-5A synthetase expression by antisense RNA interferes with interferon-mediated antiviral and antiproliferative effects and induces anchorage-independent cell growth

Cell Growth and Differentiation

Volumn 7, Issue 8, 1996, Pages 969-978

  Yaffe, Anat ^a   Schwarz, Yaacov ^a   Hacohen, Dalia ^a   Kinar, Yosefa ^a   Nir, Uri ^a   Salzberg, Samuel ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; INTERFERON; METALLOTHIONEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; MENGO VIRUS; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INFECTION; VIRUS REPLICATION;

2',5'-OLIGOADENYLATE SYNTHETASE; 3T3 CELLS; AGAR; ANIMALS; CELL DIVISION; CELLS, CULTURED; DOWN-REGULATION; EIF-2 KINASE; INTERFERONS; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RNA, ANTISENSE; TRANSFECTION; VIRUS REPLICATION; ZINC COMPOUNDS;

ANIMALIA; MENGO VIRUS; MURINAE;

EID: 0029827770     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Chebath, J., and Revel, M. The 2-5A system: 2-5A synthetases, isospecies and functions. In: S. Baron, D. H. Coppenhaver, F. Dianzani, R. Fleischmann, T. K. Hughes, G. R. Klimpel, D. W. Niesel, G. J. Stanton, and S. K. Tyring (eds.), Interferon, Principles and Medical Applications, pp. 225-236. Galveston, TX: The University of Texas Medical Branch at Galveston, Department of Microbiology, 1992.
2. Sen, G. C., and Lengyel, P. The interferon system. J. Biol. Chem., 267: 5017-5020, 1992.
3. Chebath, J., Benech, P., Hovanessian, A. G., Galabru, J., and Revel, M. Four different forms of interferon-induced 2′-5′-oligo (A) synthetase identified by immunoblotting in human cells. J. Biol. Chem., 262: 3852-3857, 1987.
4. Marie, I., and Hovanessian, A. G. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. J. Biol. Chem., 267: 9933-9939, 1992.
5. Rutherford, M. N., Kumar, A., Nissim, A., Chebath, J., and Williams, B. R. The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res., 19: 1917-1924, 1991.
6. Hovanessian, A. G. Interferon-induced and double-standard RNA-activated enzymes: a specific protein kinase and 2′,5′-oligoadenylate synthetase. J. Interferon Res., 11: 199-205, 1991.
7. Zhou, A., Hassel, B. A., and Silverman, R. H. Expression cloning of 2-5A-dependent RNase: a uniquely regulated mediator of interferon action. Cell, 72: 753-765, 1993.
8. Floyd-Smith, G., Slattery, E., and Lengyel, P. Interferon action: RNA cleavage pattern of a (2′-5′) oligoadenylate-dependent endonuclease. Science (Washington DC), 212: 1020-1032, 1981.
9. nA- dependent ribonuclease. Nature (Lond.), 289: 414-417, 1981.
10. Johnston, M. I., and Hearl, W. G. Purification and characterization of a 2′-phosphodiesterase from bovine spleen. J. Biol. Chem., 262: 8377-8382, 1987.
11. Bisbal, C., Martinand, C., Silhol, M., Lebleu, B., and Salehzada, T. Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem., 270: 13308-13317, 1995.
12. Romeo, G., Affarbis, E., Battistini, A., and Rossi, G. B. Cell and animal effects of IFNs: natural occurrence and differentiation effects and mechanisms. In: S. Baron, D. H. Coppenhaver, F. Dianzani, R. Fleischmann, T. K. Hughes, G. R. Klimpel, D. W. Niesel, G. J. Stanton, and S. K. Tyring (eds.), Interferon: Principles and Medical Applications, pp. 271-287. Galveston, TX: The University of Texas Medical Branch at Galveston, Department of Microbiology, 1992.
13. Bakhanashvili, M., Wreschner, D. H., and Salzberg, S. Specific antigrowth effect of interferon on mouse cells transformed by murine sarcoma virus. Career Res., 43: 1289-1294, 1983.
14. David, S., Nissim, A., Chebath, J., and Salzberg, S. 2-5A synthetase gene expression in normal and murine sarcoma virus-transformed NIH/3T3 cells. J. Virol., 63: 1116-1122, 1989.
15. Kumar, A., and Mendelsohn, J. Role of 2′-5′-oligoadenylate synthetase in γ-interferon-mediated growth inhibition of A431 cells. Cancer Res., 49: 5180-5184, 1989.
16. Birenbaum, M., Trink, B., Shainberg, A., and Salzberg, S. Activation of the interferon system during myogenesism vitro. Differentiation, 45: 138-145, 1990.
17. Ferbus, D., Testa, M., Titeux, M., Louache, F., and Thang, H. N. Induction of (2′-5′) oligoadenylate synthetase activity during granulocyte and monocyte differentiation. Mol. Cell. Biochem., 67: 125-133, 1985.
18. Kimchi, A. Increased levels of interferon-induced (2′-5′)oligoadenylate synthetase in mature T-lymphocytes and in differentiated Friend erythroleukemic cells. J. Interferon Res., 1: 559-569, 1981.
19. Maor, G., Salzberg, S., and Silbermann, M. The activity of 2,5-oligoadenylate synthetase, an interferon-induced enzyme, is coupled to the differentiation state of mouse condylar cartilage. Differentiation, 44: 18-24, 1990.
20. Salzberg, S., Mandelbaum, M., Zalcberg, M., and Shainberg, A. Interruption of myogenesis by transforming growth factor β1 or EGTA inhibits expression and activity of the myogenic-associated (2′-5′)oligoadenylate synthetase and PKR. Exp. Cell. Res., 219: 223-232, 1995.
21. gR cells during growth inhibition. Proc. Natl. Acad. Sci. USA, 80: 4954-4958, 1983.
22. n A-dependent RNase in NIH/3T3, clone 1 cells by growth arrest and interferon treatment. J. Biol. Chem., 260: 9501-9507, 1985.
23. Chebath, J., Benech, P., Revel, M., and Vigneron, M. Constitutive expression of (2′-5′) oligo A synthetase confers resistance to picornavirus infection. Nature (Lond.), 330: 587-588, 1987.
24. Coccia, E. M., Romeo, G., Nissim, A., Marziah, G., Albertini, R., Affarbis, E., Battistini, A., Fiorucci, G., Orsatti, R., Rossi, G. B., and Chebath, J. A full length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology, 179: 228-233, 1990.
25. Rysiecki, G., Gewert, D. R., and Williams, B. R. G. Constitutive expression of a 2′,5′-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression. J. Interferon Res., 4: 649-657, 1989.
26. Hassel, B. A., Zhou, A., Sotomayor, C., Maran, A., and Silverman, R. H. A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J., 12: 3297-3304, 1993.
27. Nellen, W., and Lichtenstein, C. What makes an mRNA anti-senseitive? Trends Biochem. Sci., 18: 419-423, 1993.
28. Tanaka, A., and Samuel, L. E. Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 91: 7995-7999, 1994.
29. Behrend, E. I., Craig, A. M., Wilson, S. M., Dehardt, D. T., and Chambers, A. F. Reduced malignancy of ras-transformed NIH-3T3 cells expressing antisense osteopontin RNA. Cancer Res., 54: 832-837, 1994.
30. Duroux, I., Godard, G., Boidot-Forget, M., Schwab, G., Helene, C., and Saison-Behmoaras, T. Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells. Nucleic Acids Res., 17: 3411-3418, 1995.
31. Li, B. D., Budnick, R. M., Russo, C. A., Anderson, G. R., and Stewart, C. C. Quantifying c-myc expression in c-myc antisense phosphorothioate oligodeoxynucleotide-treated leukemic and colon cancer cell lines. J. Surg. Res., 59: 485-492, 1995.
32. Mercola, D., and Cohen, J. S. Antisense approaches to cancer gene therapy. Cancer Gene Ther., 2: 47-59, 1995.
33. Schuch, W. Using antisense RNA to study gene function. Symp. Soc. Exp. Biol., 45: 117-127, 1991.
34. Lee, C. H., Chen, H. H., Hoke, G., Jong, J. S., White, L., and Kang, J. H. Antisense gene suppression against human ICAM-1, ELAM-1 and VCAM-1 in cultured human umbilical vein endothelial cells. Shock, 4: 1-10, 1995.
35. Valdez, B. C., Perlasky, L., Saifo, Y., Henning, D., Zhu, L., Busch, R. K., Zhang, W-W., and Busch, H. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. Cancer Res., 52: 5681-5687, 1992.
36. Bordier, B., Perala-Heape, M., Dezols, G., Lebleu, B., Litvak, S., Sarih-Cottin, L., and Helene, C. Sequence-specific inhibition of human immunodeficiency virus (HIV) reverse transcription by antisense oligonucleotides: comparative study in cell-free assays and in HIV-infected cells. Proc. Natl. Acad. Sci. USA, 92: 9383-9387, 1995.
37. Green, D. J., Pines, O., and Inouye, M. The role of antisense RNA in gene regulation. Annu. Rev. Biochem., 55: 569-597, 1986.
38. Delihas, N. Regulation of gene expression by trans-encoded antisense RNA. Mol. Microbiol., 15: 411-414, 1995.
39. Larrouy, B., Boizian, C., Sproat, B., and Toulene, J. J. RNase H is responsible for the non-specific inhibition of in vitro translation by 2′-0-alkyl chimeric oligonucleotides: high affinity or selectivity, a dilemma to design antisense oligomers. Nucleic Acids Res., 23: 3434-3440, 1995.
40. Kaudimalla, E. R., Mauring, A., Latham, C., Bym, R. A., and Agrawal, S. Design, biochemical, biophysical and biological properties of cooperative antisense oligonucleotides. Nucleic Acids Res., 23: 3578-3584, 1995.
41. Li, T., and Hightower, L. E. Effect of dexamethasone, heat shock, and serum responses on the inhibition of Hsc70 synthesis by antisense RNA in NIH 3T3 cells. J. Cell. Physiol., 164: 344-355, 1995.
42. Lengyel, P. Tumor-suppressor genes: news about the interferon connection. Proc. Natl. Acad. Sci. USA, 90: 5843-5895, 1993.
43. Kirschoff, S., Koromilas, A. E., Schaper, F., Grashoff, M., Sonenberg, N., and Hauser, H. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR. Oncogene, 11: 439-445, 1995.
44. Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., and Taniguchi, T. Anti-oncogenic and oncogenic potentials of Interferon regulatory factors-1 and -2. Science (Washington DC), 259: 971-974, 1993.
45. Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G., and Sonenberg, N. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (Washington DC), 257: 1685-1689, 1992.
46. Meurs, E. F., Galabru, J., Barber, G. N., Katze, M. G., and Hovanessian, A. G. Tumor suppressor function of the interferon-induced double stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA, 90: 232-236, 1993.
47. Barber, G. N., Jagus, R., Meurs, E. F., Hovanessian, A. G., and Katze, M. G. Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase. J. Biol. Chem., 270: 17423-17428, 1995.
48. Der, S. D., and Lau, A. S. Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Proc. Natl. Acad. Sci. USA, 92: 8841-8845, 1995.
49. Cohen, B., Peretz, D., Vaiman, D., Benech, P., and Chebath, J. Enhancer-like interferon responsive sequences of the human and murine (2′-5′) oligoadenylate synthetase gene promoters. EMBO J., 7: 1411-1419, 1988.
50. Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., and Rutter, W. J. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin stimulated kinase activity and uptake of 2-deoxyglucose. Cell, 45: 721-732, 1986.
51. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. Introduction of DNA into mammalian cells. In: F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Saidman, J. A. Smith, and K. S. Struhl (eds.), Current Protocols in Molecular Biology, pp. 9.1.1-9.1.4. New York: John Wiley & Sons, Inc., 1990.
52. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.