Effect of thrombomodulin on the molecular recognition and early catalytic events in thrombin-protein C interaction

Thrombosis and Haemostasis

Volumn 76, Issue 4, 1996, Pages 556-560

  De Cristofaro, Raimondo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; PROTEIN C; THROMBIN; THROMBOMODULIN;

ACYLATION; ARTICLE; CONTROLLED STUDY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; VISCOSITY;

EID: 0029827651     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650622     Document Type: Article

References (32)

1. Owen WG, Esmon CT. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of Protein C. J Biol Chem 1981; 256: 5532-5.
2. Walker FJ, Sexton PW, Esmon CT. The inhibition of blood coagulation by activated Protein C through the selective inactivation of Factor V. Biochim Biophys Acta 1979; 571: 333-42.
3. Esmon CT. The roles of Protein C in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-6.
4. Griffin JH, Evatt B, Zinimermann TS. Deficiency of Protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-3.
5. Kurosawa S, Stearns DJ, Jackson JB, Esmon CT. Proteolytic formation and properties of functional domains of thrombomodulin. J Biol Chem 1988; 262: 2206-12.
6. Steams DJ, Kurosawa S, Esmon CT. Microthrombomodulins. J Biol Chem 1989; 264: 3352-6.
7. Zushi M, Gomi K, Yamamoto S, Maruyama I, Hayashi T, Suzuki K. The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for Protein C-activating cofactor activity and anticoagulant activity. J Biol Chem 1989; 264: 10351-3.
8. Srinivasan J, Hu S, Hrabal R, Zhu Y, Komives EA, Ni F. Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects. Biochem 1994; 33: 13553-60.
9. Lougheed JC, Bowman CL, Meininger DP, Komives E. Thrombin inhibition by cyclic peptides from thrombomodulin. Protein Sci 1995; 4: 773-80.
10. Lentz SR, Chen Y, Sadler JE. Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. J. Biol Chem. 1993; 268: 15312-7.
11. Le Bonniec BF, Esmon CT. Glu192→Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. Proc Natl Acad Sci USA 1991; 88: 7371-5.
12. Fersht AR. In: Enzyme structure and mechanisms. Freeman, New York 1985.
13. De Cristofaro R, Rocca B, Bizzi B, Landolfi, R. The linkage between binding of C-terminal hirudin domain and amidase activity in human α-thrombin. Biochem J 1993; 289: 475-80.
14. Kisiel W, Ericsson LH, Davie EW. Proteolytic activation of Protein C from bovine plasma. Biochem 1976; 15: 4893-900.
15. Murano G, Williams L, Miller-Andersson M, Aronson D, King C. Some properties of antithrombin III and its concentration in human plasma. Thromb Res 1980; 18: 259-62.
16. Nakatani H, Dunford HB. Meaning of diffusion-controlled association rate constants in enzymology. J Phys Chem 1979; 83: 2662-5.
17. Brouwer AC, Kirsh JF. Investigation of diffusion-limited rates of chymotrypsin reaction by viscosity variation. Biochem 1982; 21: 1302-7.
18. +-activated enzyme. Biochem 1992; 31: 11721-30.
19. Cleland WW. In: Investigations of rates and mechanisms of reactions. Bernasconi CF (ed). Wiley, New York 1986; Vol. 6: pp. 791-870.
20. De Cristofaro R, Landolfi R. Thermodynamics of amide substrates and inhibitors binding to the active site cleft of human α-thrombin. J Mol Biol 1994; 239: 569-77.
21. Picozzi M, Landolfi R, De Cristofaro R. Effects of proton on the thrombin-fibrinogen interaction. Eur J Biochem 1994; 219: 1013-21.
22. Kurosawa S, Galvin JB, Esmon NL, Esmon CT. Proteolytic formation and properties of functional domains of thrombomodulin. J Biol Chem 1987; 262: 2206-12.
23. Calvin JB, Kurosawa S, Moore K, Esmon CT, Esmon NL. Reconstitution of rabbit thrombomodulin into phospholipid vesicles. J Biol Chem 1987; 262: 2199-205.
24. 2+ dependence of the interactions between Protein C, thrombin and the elastase fragment of thrombomodulin. Analysis by ultracentrifugation. Biochem 1992; 31: 746-54.
25. De Cristofaro R, Picozzi M, De Candia E, Rocca B, Landolfi R. Energetics of thrombin-thrombomodulin interaction. Biochem J 1995; 310: 49-53.
26. Stone SR, Betz A, Hofsteenge J. Mechanistic studies of thrombin catalysis. Biochemistry 1991; 30: 9841-8.
27. Stone SR, Hermans JM. Inhibitory mechanism of Serpins. Interaction of thrombin with antithrombin and protease Nexin I. Biochem 1995; 34: 5164-72.
28. 2+ binding to a high affinity site that does not contain carboxyglutamic acid. J Biol Chem 1983; 258: 5554-60.
29. Bauer KA. In: Hematology. Basic principles and practice. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE (eds). 2nd ed. New York: Churchill Livingstone 1995; p 1787.
30. Picozzi M, De Cristofaro R. Effect of temperature on thrombin-fibrinogen interaction. Biochem J 1993; 294: 563-7.
31. De Cristofaro R, Picozzi M, Morosetti R, Landolfi R. The effect of sodium on the energetics of thrombin-lhrornbomodulin interaction and its relevance for Protein C hydrolysis. J Mol Biol 1996; 258: 190-200.
32. + binding site of thrombin. J Biol Chem 1995; 270: 22089-92.