Blockade of angiotensin receptors in rat rostral ventrolateral medulla removes excitatory vasomotor tone

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Ito, Satoru ^a   Sved, Alan F ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

blood pressure; brain stem; muscimol; sympathetic nervous system

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE]; ANGIOTENSIN II [1 SARCOSINE 8 THREONINE]; ANGIOTENSIN RECEPTOR; CHLORISONDAMINE; MUSCIMOL;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029827490     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.6.r1317     Document Type: Article

References (39)

1. Allen, A. M., R. A. L. Dampney, and F. A. O. Mendelsohn. Angiotensin receptor binding and pressor effects in cat subretrofacial nucleus. Am. J. Physiol. 255 (Heart Circ. Physiol. 24): H1011-H1017, 1988.
2. Andreatta, S. H., D. B. Averill, R. A. S. Santos, and C. M. Ferrario. The ventrolateral medulla: a new site of the action of the renin-angiotensin system. Hypertension Dallas 11, Suppl. I: I163-I166, 1988.
3. Averill, D. B., T. Tsuchihashi, M. C. Khosla, and C. M. Ferrario. Losartan, nonpeptide angiotensin II-type 1 (AT1) receptor antagonist, attenuates pressor and sympathoexcitatory responses evoked by angiotensin II and L-glutamate in rostral ventrolateral medulla. Brain Res. 665: 245-252, 1994.
4. Chan, R. K. W., Y. S. Chan, and T. M. Wong. Responses of cardiovascular neurons in the rostral ventrolateral medulla of the normotensive Wistar Kyoto and spontaneously hypertensive rats to iontophoretic application of angiotensin II. Brain Res. 556: 145-150, 1991.
5. 8] -angiotensin II on rostral ventrolateral medulla neurons and blood pressure in spontaneously hypertensive rats. Neuroscience 63: 267-277, 1994.
6. Dampney, R. A. L. The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog. Neurobiol. 42: 197-227, 1994.
7. Fontes, M. A. P., L. C. S. Silva, M. J. Campagnole-Santos, M. C. Khosla, P. G. Guertzenstein, and R. A. S. Santos. Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain Res. 665: 175-180, 1994.
8. Giuliano, R., D. A. Ruggiero, S. Morrison, P. Ernsberger, and D. J. Reis. Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. J. Neurosci. 9: 923-942, 1989.
9. 1 epinephrine neurons mediates baroreflex vasopressor responses. Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H547-H567, 1985.
10. Guyenet, P. G. Role of the ventral medulla oblongata in blood pressure regulation. In: Central Regulation of Autonomic Functions, edited by A. D. Loewy and K. M. Spyer. New York: Oxford University Press, 1990, p. 145-167.
11. Hall, M. M., M. C. Khosla, P. A. Khairallah, and F. M. Bumpus. Angiotensin analogs: the influence of sarcosine substituted in position 1. J. Pharmacol. Exp. Ther. 188: 222-228, 1974.
12. Hayes, K., F. R. Calaresu, and L. C. Weaver. Pontine reticular neurons provide tonic excitation to neurons in rostral ventrolateral medulla in rats. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R237-R244, 1994.
13. 8 AII) in normotensive and spontaneously hypertensive rat strains. Brain Res. 448: 359-363, 1988.
14. Kiely, J. M., and F. J. Gordon. Role of rostral ventrolateral medulla in centrally mediated pressor responses. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1549-H1556, 1994.
15. Li, Y.-W., and P. G. Guyenet. Neuronal excitation by angiotensin II in the rostral ventrolateral medulla of the rat in vitro. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R272-R277, 1995.
16. Li, Y.-W., J. W. Polson, and R. A. L. Dampney. Angiotensin II excites vasomotor neurons but not respiratory neurons in the rostral and caudal ventrolateral medulla. Brain Res. 577: 161-164, 1992.
17. Lind, R. W., L. W. Swanson, and D. Ganten. Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. Neuroendocrinology 40: 2-24, 1985.
18. Mendelsohn, F. A. O., A. M. Allen, J. Clevers, D. A. Denton, E. Tarjan, and M. J. McKinley. Localization of angiotensin II receptor binding in rabbit brain by in vitro autoradiography. J. Comp. Neurol. 270: 372-384, 1988.
19. Morrison, S. F., and D. J. Reis. Reticulospinal vasomotor neurons in RVL mediate the somatosympathetic reflex. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 25): R1084-R1097, 1989.
20. Munoz-Ramirez, H., M. C. Khosla, M. M. Hall, F. M. Bumpus, and P. A. Khairallah. In vitro and in vivo studies of [1-sarcosine, 8-threonine] angiotensin II. Res. Comm. Chem. Path. Pharm. 13: 649-663, 1976.
21. Muratani, H., D. B. Averill, and C. M. Ferrario. Effect of angiotensin II in ventrolateral medulla of spontaneously hypertensive rats. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R977-R984, 1991.
22. Muratani, H., C. M. Ferrario, and D. B. Averill. Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R388-R395, 1993.
23. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates. Orlando: Academic, 1986.
24. Ross, C. A., D. A. Ruggiero, D. H. Park, T. H. Joh, A. F. Sved, J. Fernandez-Pardal, J. M. Saavedra, and D. J. Reis. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin. J. Neurosci. 4: 474-494, 1984.
25. Saigusa, T., and G. A. Head. Renal sympathetic baroreflex effects of angiotensin II infusions into the rostral ventrolateral medulla of the rabbit. Clin. Exp. Pharmacol. Physiol. 20: 351-354, 1993.
26. Sasaki, S., and R. A. L. Dampney. Tonic cardiovascular effects of angiotensin II in the ventrolateral medulla. Hypertension Dallas 15: 274-283, 1990.
27. Sasaki, S., Y.-W. Li, and R. A. L. Dampney. Comparison of the pressor effects of angiotensin II and III in the rostral ventrolateral medulla. Brain Res. 600: 335-338, 1993.
28. Schreihofer, A. M., and A. F. Sved. Role of the rostral ventrolateral medulla in the maintenance of arterial pressure in chronically baroreceptor denervated rats. Neurosci. Abstr. 21: 889, 1995.
29. Silva, L. C. S., M. A. P. Fontes, M. J. Campagnole-Santos, M. C. Khosla, R. R. Campos, P. G. Guertzenstein, and R. A. S. Santos. Cardiovascular effects produced by micro-injection of angiotensin-(1-7) on vasopressor and vasodepressor sites of the ventrolateral medulla. Brain Res. 613: 321-325, 1993.
30. Song, K.-F., A. M. Alien, G. Paxinos, and F. A. O. Mendelsohn. Mapping of angiotensin receptor subtype heterogeneity in rat brain. J. Comp. Neurol. 316: 467-484, 1992.
31. Stornetta, R., S. L. Morrison, D. A. Ruggiero, and D. J. Reis. Neurons in the rostral ventrolateral medulla mediate the somatic pressor reflex. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 26): R448-R462, 1989.
32. Sun, M.-K., and P. G. Guyenet. Hypothalamic glutamatergic input to medullary sympathoexcitatory neurons in rats. Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20): R798-R810, 1986.
33. Tsukamoto, K., M. Yin, and A. F. Sved. Effect of atropine injected into the nucleus tractus solitarius on the regulation of blood pressure. Brain Res. 648: 9-15, 1994.
34. Verberne, A. J. M., and P. G. Guyenet. Midbrain central gray: influence on medullary sympathoexcitatory neurons and the baroreflex in rats. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R24-R33, 1992.
35. Willette, R. N., P. A. Gatti, and H. N. Sapru. GABAergic mechanisms in the ventrolateral medulla alter vasopressor responses from the anterior hypothalamus. J. Cardiovasc. Pharmacol. 6: 476-482, 1984.
36. Willette, R. N., A. J. Krieger, P. P. Barcas, and H. N. Sapru. Medullary gamma-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226: 893-899, 1983.
37. Willette, R. N., S. Punnen, A. J. Krieger, and H. N. Sapru. Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 231: 457-463, 1984.
38. Willette, R. N., S. Punnen, A. J. Krieger, and H. N. Sapru. Interdependence of rostral and caudal ventrolateral medullary areas in the control of blood pressure. Brain Res. 321: 169-174, 1984.
39. Wright, J. W., L. L. Jensen, K. A. Roberts, M. F. Sardinia, and J. W. Harding. Structure-function analyses of brain angiotensin control of pressor action in rats. Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 26): R1551-R1557, 1989.