Multistage designs for phase II clinical trials: Statistical issues in cancer research

British Journal of Cancer

Volumn 74, Issue 8, 1996, Pages 1317-1320

  Kramar, A ^b   Potvin, D ^a,b   Hill, C ^b  

^a MDS Inc   (Canada)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Multistage design; Phase II clinical trial

Indexed keywords

ARTICLE; CANCER RESEARCH; CLINICAL PROTOCOL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0029827296     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.537     Document Type: Article

References (5)

1. ENSIGN LG, GEHAN EA, KAMEN DS AND THALL P. (1994). An optimal three-stage design for phase II clinical trials. Stat. Med., 13, 1727-1736.
2. FLEMING TR. (1982). One sample multiple testing procedure for phase II clinical trials. Biometrics, 38, 143-151.
3. GEHAN EA. (1961). The determination of the number of patients required in a preliminary and a follow-up trial of a new chemotherapy agent. J. Chron. Dis., 13, 346-353.
4. MACHIN D, CAMPBELL MJ, FAYERS PM AND PINOL A. (1996). Sample size tables for clinical studies. Blackwell Scientific Publications: Oxford.
5. SIMON R (1989). Optimal two-stage designs for phase II clinical trials. Controlled Clin. Trials. 10, 1-10.