Immunological identification and localization of yeast aspartic protease 3-like prohormone-processing enzymes in mammalian brain and pituitary

Endocrinology

Volumn 137, Issue 11, 1996, Pages 5135-5143

  Cawley, Niamh X ^a   Pu, Le Ping ^a   Loh, Y Peng ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE;

ANIMAL TISSUE; ARTICLE; BRAIN; CATTLE; CONTROLLED STUDY; ENZYME LOCALIZATION; HORMONE SYNTHESIS; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0029827093     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895388     Document Type: Article

References (48)

1. Loh YP, Brownstein MJ, Gainer H 1984 Proteolysis in neuropeptide processing and other neural functions. Annu Rev Neurosci 7:189-222
2. Loh YP, Beinfeld MC, Birch NP 1993 Proteolytic processing of prohormones and pro-neuropeptides. In: Loh YP (ed) Mechanisms of Intracellular Trafficking and Processing of Proproteins. CRC Press, Boca Raton, pp 179-224
3. Mains RE, Dickerson IM, May V, Stoffers DA, Perkins SN, Ouafik LH, Husten EJ, Eipper BA 1990 Cellular and molecular aspects of peptide hormone biosynthesis. Front Neuroendocrinol 11:52-89
4. Mackin R, Noe B, Spiess J 1991 Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the Kex2/furin/PC family. Endocrinology 129:2263-2265
5. Fricker L 1988 Carboxypeptidase E. Annu Rev Physiol 50:309-321
6. Fuller RS, Brake AJ, Thorner J 1989 Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 264:482-486
7. Julius D, Brake A, Blair L, Kunisawa R, Thorner J 1984 Isolation of the putative structural gene for the lysine-arginine cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell 37:1075-1089
8. 2+ dependent serine protease. Proc Natl Acad Sci USA 86:1434-1438
9. Seidah NG, Day R, Marcinkiewicz M, Chretien M 1993 Mammalian paired basic amino acid convertases of prohormones and proproteins. Ann NY Acad Sci 680:135-146
10. Steiner DF, Smeekens SP, Ohagi S, Chan SJ 1992 The new enzymology of precursor processing endoproteases. J Biol Chem 267:23435-23438
11. Lindberg I 1991 The new eukaryotic precursor processing proteinases. Mol Endocrinol 5:1361-1365
12. Seidah NG, Day R, Benjannet S, Rondeau N, Boudreault A, Reudelhuber T, Schafer MK-H, Watson SJ, Chretien M 1992 The prohormone and proprotein processing enzymes PC1 and PC2: structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation. NIDA Res Monogr 126:132-150
13. Egel-Mitani M, Flygenring HP, Hansen MT 1990 A novel aspartyl protease allowing Kex2-independent MF alpha propheromone processing in yeast. Yeast 6:127-137
14. Azaryan AV, Wong M, Friedman TC, Cawley NX, Estivariz FE, Chen HC, Loh YP 1993 Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme. J Biol Chem 268:11968-11975
15. Cawley NX, Wong M, Pu LP, Tam W, Loh YP 1995 Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: characterization of secreted YAP3p. Biochemistry 34:7430-7437
16. Ash J, Dominguez M, Bergeron JJ, Thomas DY, Bourbonnais Y 1995 The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane. J Biol Chem 270:20847-20854
17. Bourbonnais Y, Germain D, Ash J, Thomas DY 1994 Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease. Biochimie 76:226-233
18. Cawley NX, Chen H-C, Beinfeld MC, Loh YP 1996 Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3. J Biol Chem 271:4168-4176
19. Cawley NX Noe BD, Loh YP 1993 Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28. FEBS Lett 332:273-276
20. Komano H, Fuller RS 1995 Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast. Proc Natl Acad Sci USA 92:10752-10756
21. Parish DC, Tuteja R, Altstein M, Gainer H, Loh YP 1986 Purification and characterization of a paired basic residue-specific prohormone-converting enzyme from bovine pituitary neural lobe secretory vesicles. J Biol Chem 261:14392-14397
22. Loh YP, Parish DC, Tuteja R 1985 Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles. J Biol Chem 260:7194-7205
23. Chang TL, Loh YP 1984 In vitro processing of proopiocortin by membraneassociated and soluble converting enzyme activities from rat intermediate lobe secretory granules. Endocrinology 114:2092-2099
24. Chang TL, Loh YP 1983 Characterization of proopiocortin converting activity in rat anterior pituitary secretory granules. Endocrinology 112:1832-8
25. Azaryan AV, Schiller M, Mende-Mueller L, Hook VY 1995 Characteristics of the chromaffin granule aspartic proteinase involved in proenkephalin processing. J Neurochem 65:1771-1779
26. Loh YP, Tam WWH, Russell JT 1984 Measurement of Δ-pH and membrane potential in secretory vesicles isolated from bovine pituitary intermediate lobe. J Biol Chem 259:8238-8245
27. Birch NP, Estivariz FE, Bennett HP, Loh YP 1991 Differential glycosylation of N-POMC1-77 regulates the production of γ3-MSH by purified pro-opiomelanocortin converting enzyme. A possible mechanism for tissue-specific processing. FEBS Lett 290:191-194
28. Pu LP, Charnay Y, Leduque P, Morel G, Dubois PM 1991 Light and electron microscopic immunocytochemical evidence that delta sleep-inducing peptide and gonadotropin-releasing hormone are coexpressed in the same nerve structures in the guinea pig median eminence. Neuroendocrinology 53:332-338
29. Pu LP, Hayes WP, Mill JF, Ghose S, Friedman TC, Loh YP 1995 Frog prohormone convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing hormone-expressing neurons. J Comp Neurol 354:71-86
30. Siegel RE, Young WS, II I 1985 Detection of preprocholecystokinin and preproenkephalin A mRNAs in rat brain by hybridization histochemistry using complementary RNA probes. Neuropeptides 6:573-580
31. Pu LP, Van Leeuwen FW, Tracer HL, Sonnemans MA, Loh YP 1995 Localization of vasopressin mRNA and immunoreactivity in pituicytes of pituitary stalk-transected rats after osmotic stimulation. Proc Natl Acad Sci USA 92:10653-10657
32. Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN, Numa S 1979 Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278:423-427
33. Loh YP, Cawley NX, Friedman TC, Pu L-P 1995 Yeast and mammalian basic residue-specific aspartic proteases in prohormone processing. In: Takahashi K (ed) Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications. Plenum Press, New York, pp 519-527
34. Zhou Y, Lindberg I 1993 Purification and characterization of the prohormone convertase PC1 (PC3). J Biol Chem 268:5615-5623
35. Zhou Y, Lindberg I 1994 Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion. J Biol Chem 269:18408-18413
36. Hill RM, Ledgerwood EC, Brennan SO, Pu LP, Loh YP, Christie DL, Birch NP 1995 Comparison of the molecular forms of the Kex2/subtilisin-like serine proteases SPC2, SPC3, and furin in neuroendocrine secretory vesicles reveals differences in carboxyl-terminus truncation and membrane association. J Neurochem 65:2318-2326
37. Perryman E 1988 Melanotropins: pars intermedia structure and function. In: Hadley ME (ed) The Melanotropic Peptides. CRC Press, Boca Raton, pp 5-23
38. Day R, Schafer MK-H, Watson SJ, Chretien M, Seidah NG 1992 Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Mol Endocrinol 6:485-497
39. Benjannet S, Rondeau N, Day R, Chretien M, Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 88:3564-3568
40. Thomas L, Leduc R, Thorne B, Smeekens S, Steiner D, Thomas G 1991 Kex2-Iike endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc Natl Acad Sci USA 88:5297-5301
41. Friedman TC, Loh YP, Birch NP 1994 In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3). Endocrinology 135:854-862
42. Watson SJ, Barchas JD, Li CH 1977 β-Lipotropin: localization of cells and axons in rat brain by immunocytochemistry. Proc Natl Acad Sci USA 74:5155-5158
43. Sofroniew MV 1979 Immunoreactive beta-endorphin and ACTH in the same neurons of the hypothalamic arcuate nucleus in the rat. Am J Anat 154:283-289
44. Handelmann GE, Beinfeld MC, O'Donohue TL, Nelson JB, Brenneman DE 1983 Extra-hippocampal projections of CCK neurons of the hippocampus and subiculum. Peptides 4:331-334
45. Seroogy KB, Fallon JH 1989 Forebrain projections from cholecystokinin-like immunoreactive neurons in the rat midbrain. J Comp Neurol 279:415-435
46. Vandesande F, Dierickx K 1975 Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretroy system of the rat. Cell Tissue Res 164:153-162
47. Pu L-P, Ma W, Barker JL, Loh YP 1996 Differential coexpression of genes encoding prothyrotropin-releasing hormone (pro-TRH) and prohormone convertases (PC1 and PC2) in rat brain neurons: implications for differential processing of pro-TRH. Endocrinology 137:1233-1241
48. Parish D 1986 Prohormone-converting enzymes. In: Moody TW (ed) Neural and Endocrine Peptides and Receptors. Plenum Press, New York, pp 35-43