-
1
-
-
0028144874
-
Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding
-
Beard, W. A., and S. H. Wilson. 1994. Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding. Curr. Opin. Biotechnol. 5:414-421.
-
(1994)
Curr. Opin. Biotechnol.
, vol.5
, pp. 414-421
-
-
Beard, W.A.1
Wilson, S.H.2
-
2
-
-
0003006421
-
Reverse transcriptase
-
J. Karn (ed.), IRL Press, Oxford
-
Beard, W. A., and S. H. Wilson. 1995. Reverse transcriptase, p. 15-36. In J. Karn (ed.), HIV: a practical approach. IRL Press, Oxford.
-
(1995)
HIV: A Practical Approach
, pp. 15-36
-
-
Beard, W.A.1
Wilson, S.H.2
-
3
-
-
0028997906
-
Intraccllular antibodies: Antibody targeting to subcellular compartments
-
Biocca, S., and A. Cattaneo. 1995. Intraccllular antibodies: antibody targeting to subcellular compartments. Trends Cell Biol. 5:248-252.
-
(1995)
Trends Cell Biol.
, vol.5
, pp. 248-252
-
-
Biocca, S.1
Cattaneo, A.2
-
4
-
-
0025122362
-
Expression and targeting of intraccllular antibodies in mammalian cells
-
Biocca, S., M. Neuberger, and A. Cattaneo. 1990. Expression and targeting of intraccllular antibodies in mammalian cells. EMBO J. 9:101-108.
-
(1990)
EMBO J.
, vol.9
, pp. 101-108
-
-
Biocca, S.1
Neuberger, M.2
Cattaneo, A.3
-
5
-
-
0027974928
-
2.3 A crystal structure of the catalytic domain of DNA polymerase beta
-
Davies, J. F., R. J. Almassy, Z. Hostomska, R. A. Ferre, and Z. Hostomsky. 1994. 2.3 A crystal structure of the catalytic domain of DNA polymerase beta. Cell 76:1123-1133.
-
(1994)
Cell
, vol.76
, pp. 1123-1133
-
-
Davies, J.F.1
Almassy, R.J.2
Hostomska, Z.3
Ferre, R.A.4
Hostomsky, Z.5
-
6
-
-
0028120730
-
HIV resistance to reverse transcriptase inhibitors
-
De Clerq, E. 1994. HIV resistance to reverse transcriptase inhibitors. Biochem. Pharmacol. 47:155-169.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 155-169
-
-
De Clerq, E.1
-
7
-
-
0025040632
-
An attempt to unify the structure of polymerascs
-
Delarue, M., O. Poch, D. Tordo, D. Moras, and P. Argos. 1990. An attempt to unify the structure of polymerascs. Protein Eng. 6:461-467.
-
(1990)
Protein Eng.
, vol.6
, pp. 461-467
-
-
Delarue, M.1
Poch, O.2
Tordo, D.3
Moras, D.4
Argos, P.5
-
8
-
-
0028237267
-
Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody
-
Duan, L., O. Bagasra, M. A. Laughlin, J. W. Oakes, and R. Pomerantz. 1994. Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody. Proc. Natl. Acad. Sci. USA 91: 5075-5079.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5075-5079
-
-
Duan, L.1
Bagasra, O.2
Laughlin, M.A.3
Oakes, J.W.4
Pomerantz, R.5
-
9
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
Esnouf, R., J. Ren, C. Ross, Y. Jones, D. Stammers, and D. Stuart. 1995. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nature (London) Struct. Biol. 2:303-308.
-
(1995)
Nature (London) Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
10
-
-
0025829251
-
Monoclonal antibodies define linear and conformational epitopes of HIV-1 pol gene products
-
Ferns, R. B., J. C. Partridge, M. Tisdale, N. Hunt, and R. Tedder. 1991. Monoclonal antibodies define linear and conformational epitopes of HIV-1 pol gene products. AIDS Res. Hum. Retroviruses 6:307-313.
-
(1991)
AIDS Res. Hum. Retroviruses
, vol.6
, pp. 307-313
-
-
Ferns, R.B.1
Partridge, J.C.2
Tisdale, M.3
Hunt, N.4
Tedder, R.5
-
11
-
-
0025309572
-
Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure
-
Ferris, A., A. Hizi, S. D. Showalter, S. Pichuantes, and S. H. Hughes. 1990. Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure. Virology 175:456-464.
-
(1990)
Virology
, vol.175
, pp. 456-464
-
-
Ferris, A.1
Hizi, A.2
Showalter, S.D.3
Pichuantes, S.4
Hughes, S.H.5
-
12
-
-
0028971801
-
Progress in anti-HIV structure-based drug design
-
Gait, M. J., and J. Karn. 1995. Progress in anti-HIV structure-based drug design. Trends Biotechnol. 13:430-438.
-
(1995)
Trends Biotechnol.
, vol.13
, pp. 430-438
-
-
Gait, M.J.1
Karn, J.2
-
14
-
-
0029645414
-
Mechanistic implication from the structure of a catalytic fragment of Moloncy leukemia virus reverse transcriptase
-
Georgiadis, M. M., S. M. Jessen, C. M. Ogata, A. Telesnitsky, S. P. Goff, and W. Hendrickson. 1995. Mechanistic implication from the structure of a catalytic fragment of Moloncy leukemia virus reverse transcriptase. Structure 3:879-892.
-
(1995)
Structure
, vol.3
, pp. 879-892
-
-
Georgiadis, M.M.1
Jessen, S.M.2
Ogata, C.M.3
Telesnitsky, A.4
Goff, S.P.5
Hendrickson, W.6
-
15
-
-
0028291823
-
Isolation of high affinity human antibodies directly from large synthetic repertoires
-
Griffiths, A. D., S. C. Williams, O. Hartley, I. M. Tomlinson, P. Waterhouse, W. Crosby, R. Konterman, P. Jones, N. M. Low, T. D. Prospero, H. R. Hoogenboom, A. Nissim, J. Cox, J. Harrison, M. Zaccolo, E. Gherardi, and G. Winter. 1994. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13:3245-3260.
-
(1994)
EMBO J.
, vol.13
, pp. 3245-3260
-
-
Griffiths, A.D.1
Williams, S.C.2
Hartley, O.3
Tomlinson, I.M.4
Waterhouse, P.5
Crosby, W.6
Konterman, R.7
Jones, P.8
Low, N.M.9
Prospero, T.D.10
Hoogenboom, H.R.11
Nissim, A.12
Cox, J.13
Harrison, J.14
Zaccolo, M.15
Gherardi, E.16
Winter, G.17
-
16
-
-
0025831249
-
Catalytic properties of the reverse transcriptase of human immunodeficiency viruses type 1 and type 2
-
Hizi, A., R. Tal, M. Shaharabany, and S. Loya. 1991. Catalytic properties of the reverse transcriptase of human immunodeficiency viruses type 1 and type 2. J. Biol. Chem. 266:6230-6239.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 6230-6239
-
-
Hizi, A.1
Tal, R.2
Shaharabany, M.3
Loya, S.4
-
17
-
-
0029880853
-
What is the orientation of DNA polymerases on their templates?
-
Hughes, S. H., Z. Hostomsky, S. F. Le Grice, K. Lentz, and E. Arnold. 1996. What is the orientation of DNA polymerases on their templates? J. Virol. 70:2679-2683.
-
(1996)
J. Virol.
, vol.70
, pp. 2679-2683
-
-
Hughes, S.H.1
Hostomsky, Z.2
Le Grice, S.F.3
Lentz, K.4
Arnold, E.5
-
18
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
-
Jacobo-Molina, A., J. Ding, R. Nanni, A. Clark, D. X. Lu, C. Tantillo, R. L. Williams, G. Kamer, A. L. Ferris, P. Clark, A. Hizi, S. H. Hughes, and E. nold. 1993. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc. Natl. Acad. Sci. USA 90:6320-6324.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.2
Nanni, R.3
Clark, A.4
Lu, D.X.5
Tantillo, C.6
Williams, R.L.7
Kamer, G.8
Ferris, A.L.9
Clark, P.10
Hizi, A.11
Hughes, S.H.12
Nold, E.13
-
19
-
-
0028983795
-
Crystal structure of Thermus aquaticus DNA polymerase
-
Kim, Y., S. H. Eom, J. Wang, D. S. Lee, S. W. Suh, and T. A. Steitz. 1995. Crystal structure of Thermus aquaticus DNA polymerase. Nature (London) 376:612-616.
-
(1995)
Nature (London)
, vol.376
, pp. 612-616
-
-
Kim, Y.1
Eom, S.H.2
Wang, J.3
Lee, D.S.4
Suh, S.W.5
Steitz, T.A.6
-
20
-
-
0026693137
-
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt, L. A., J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz. 1992. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
21
-
-
0000456849
-
Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance
-
A. Skalka (ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
Larder, B. A. 1993. Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance, p. 205-222. In A. Skalka (ed.). Reverse transcriptase. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(1993)
Reverse Transcriptase
, pp. 205-222
-
-
Larder, B.A.1
-
22
-
-
0029064110
-
Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro
-
Maciejeski, J. P., F. F. Weichold, N. S. Young, A. Cara, D. Zella, M. S. Reitz, and R. C. Gallo. 1995. Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro. Nature (London) Med. 1:667-673.
-
(1995)
Nature (London) Med.
, vol.1
, pp. 667-673
-
-
Maciejeski, J.P.1
Weichold, F.F.2
Young, N.S.3
Cara, A.4
Zella, D.5
Reitz, M.S.6
Gallo, R.C.7
-
23
-
-
0027275371
-
Design, intracellular expression, and activity of human anti-human immunodeficiency virus type 1 gp120 single-chain antibody
-
Marasco, W. A., W. A. Haseltine, and S. Chen. 1993. Design, intracellular expression, and activity of human anti-human immunodeficiency virus type 1 gp120 single-chain antibody. Proc. Natl. Acad. Sci. USA 90:7889-7893.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 7889-7893
-
-
Marasco, W.A.1
Haseltine, W.A.2
Chen, S.3
-
24
-
-
0026317443
-
Bypassing immunization: Human antibodies from V-gene libraries displayed on phage
-
Marks, J. D., H. R. Hoogenboom, T. P. Bonnert, J. McCafferty, A. D. Griffiths, and G. Winter. 1991. Bypassing immunization: human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222:581-597.
-
(1991)
J. Mol. Biol.
, vol.222
, pp. 581-597
-
-
Marks, J.D.1
Hoogenboom, H.R.2
Bonnert, T.P.3
McCafferty, J.4
Griffiths, A.D.5
Winter, G.6
-
25
-
-
0028914482
-
Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies
-
Mhashilkar, A. M., J. Bagley, S. Y. Chen, A. M. Szilvary, D. G. Helland, and W. A. Marasco. 1995. Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies. EMBO J. 14:1542-1551.
-
(1995)
EMBO J.
, vol.14
, pp. 1542-1551
-
-
Mhashilkar, A.M.1
Bagley, J.2
Chen, S.Y.3
Szilvary, A.M.4
Helland, D.G.5
Marasco, W.A.6
-
26
-
-
0029052967
-
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase
-
Patel, P. H., A. Jacobo-Molina, J. Ding, C. Tantillo, J. Clark, A. D., R. Raag, R. G. Nanni, S. H. Hughes, and E. Arnold. 1995. Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Biochemistry 34:5351-5363.
-
(1995)
Biochemistry
, vol.34
, pp. 5351-5363
-
-
Patel, P.H.1
Jacobo-Molina, A.2
Ding, J.3
Tantillo, C.4
Clark, J.5
D., A.6
Raag, R.7
Nanni, R.G.8
Hughes, S.H.9
Arnold, E.10
-
27
-
-
0028947588
-
High resolution structures of HIV-1 RT from four RT-inhibitor complexes
-
Ren, J., R. Esnouf, E. Garman, D. Somers, C. Ross, I. Kirby, J. Keeling, G. Darby, Y. Jones, D. Stuart, and D. Stammers. 1995. High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Nature (London) Struct. Biol. 2:293-308.
-
(1995)
Nature (London) Struct. Biol.
, vol.2
, pp. 293-308
-
-
Ren, J.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
Kirby, I.6
Keeling, J.7
Darby, G.8
Jones, Y.9
Stuart, D.10
Stammers, D.11
-
28
-
-
0029645409
-
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: Lesson for inhibitor design
-
Ren, J., R. Esnouf, A. Hopkins, C. Ross, Y. Jones, D. Stammers and D. Stuart. 1995. The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lesson for inhibitor design. Structure 3:915-926.
-
(1995)
Structure
, vol.3
, pp. 915-926
-
-
Ren, J.1
Esnouf, R.2
Hopkins, A.3
Ross, C.4
Jones, Y.5
Stammers, D.6
Stuart, D.7
-
29
-
-
0026647870
-
Structure-function relationships of HIV-1 reverse transcriptase determined using monoclonal antibodies
-
Restle, T., M. Pawlita, G. Sczakiel, B. Muller, and R. G. Goody. 1992. Structure-function relationships of HIV-1 reverse transcriptase determined using monoclonal antibodies. J. Biol. Chem. 267:14654-14661.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 14654-14661
-
-
Restle, T.1
Pawlita, M.2
Sczakiel, G.3
Muller, B.4
Goody, R.G.5
-
30
-
-
0029114769
-
Intracellular antibodies: Development and therapeutic potential
-
Richardson, J. H., and W. A. Marasco. 1995. Intracellular antibodies: development and therapeutic potential. Trends Biotechnol. 13:306-310.
-
(1995)
Trends Biotechnol.
, vol.13
, pp. 306-310
-
-
Richardson, J.H.1
Marasco, W.A.2
-
32
-
-
0004136246
-
-
Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989 Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
-
(1989)
Molecular Cloning, a Laboratory Manual, 2nd Ed.
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
33
-
-
0028136070
-
Crystal structure of rat DNA polymerase beta: Evidence for a common polymerase mechanism
-
Sawaya, M. R., H. Pelletier, A. Kumar, S. H. Wilson, and J. Kraut. 1994 Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science 264:1930-1935.
-
(1994)
Science
, vol.264
, pp. 1930-1935
-
-
Sawaya, M.R.1
Pelletier, H.2
Kumar, A.3
Wilson, S.H.4
Kraut, J.5
-
35
-
-
0028172345
-
Location of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase
-
Tantillo, C., J. Ding, A. Jacobo-Molina, R. G. B. Nanni, B. R., S. H. Hughes, R. Pauels, K. Andries, P. A. Janssen, and E. Arnold. 1994. Location of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. J. Mol. Biol. 243:369-387.
-
(1994)
J. Mol. Biol.
, vol.243
, pp. 369-387
-
-
Tantillo, C.1
Ding, J.2
Jacobo-Molina, A.3
Nanni, R.G.B.4
R., B.5
Hughes, S.H.6
Pauels, R.7
Andries, K.8
Janssen, P.A.9
Arnold, E.10
-
36
-
-
0023788116
-
Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: Role of the C terminus in antibody reactivity and enzyme function
-
Tisdale, M., P. Ertl, B. A. Larder, D. J. Purifoy, G. Darby, and K. L. Powell. 1988. Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function. J. Virol. 62:3662-3667.
-
(1988)
J. Virol.
, vol.62
, pp. 3662-3667
-
-
Tisdale, M.1
Ertl, P.2
Larder, B.A.3
Purifoy, D.J.4
Darby, G.5
Powell, K.L.6
-
37
-
-
0026785856
-
The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
-
Tomlinson, I. M., G. Walter, J. D. Marks, M. B. Llewelyn, and G. Winter. 1992. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 227:776-798.
-
(1992)
J. Mol. Biol.
, vol.227
, pp. 776-798
-
-
Tomlinson, I.M.1
Walter, G.2
Marks, J.D.3
Llewelyn, M.B.4
Winter, G.5
-
38
-
-
0027962758
-
Making antibodies by phage display technology
-
Winter, G., A. D. Griffiths, R. E. Hawkins, and H. R. Hoogenboom. 1994. Making antibodies by phage display technology. Annu. Rev. Immunol. 12: 433-455.
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 433-455
-
-
Winter, G.1
Griffiths, A.D.2
Hawkins, R.E.3
Hoogenboom, H.R.4
-
39
-
-
0027280807
-
Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity
-
Wu, J., E. Amandoron, X. Li, M. A. Wainberg, and M. A. Parniak. 1993. Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity. J. Biol. Chem. 268:9980-9985.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9980-9985
-
-
Wu, J.1
Amandoron, E.2
Li, X.3
Wainberg, M.A.4
Parniak, M.A.5
-
40
-
-
0028041714
-
Progress towards gene therapy for HIV infection
-
Yu, M., E. Poeschla, and F. Wong-Staal. 1994. Progress towards gene therapy for HIV infection. Gene Ther. 1:13-26.
-
(1994)
Gene Ther.
, vol.1
, pp. 13-26
-
-
Yu, M.1
Poeschla, E.2
Wong-Staal, F.3
|