Glutamate transport modulation of paracellular permeability across LLC- PK1-F+ monolayers

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 5 34-5, 1996, Pages

  Welbourne, T C ^a   Chevalier, D ^a   Mu, X ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

electrical resistance; gamma glutamyltransferase; glutamine; L glucose permeability; RK13; tight junction

Indexed keywords

3 HYDROXYASPARTIC ACID; ALANINE; ASPARTIC ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; ELECTRIC RESISTANCE; KIDNEY PROXIMAL TUBULE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; SWINE; TIGHT JUNCTION;

EID: 0029826688     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.5.e889     Document Type: Article

References (32)

1. Balcar, V. J., G. A. R. Johnston, and B. Twitchin. Stereospecificity of the inhibition of L-glutamate and L-aspartate high affinity uptake in brain slices by threo-3-hydroxyaspartate. J. Neurochem. 28: 1145-1146, 1977
2. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
3. 1 cells. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F1038-F1045, 1991
4. Christofinis, G. J., and A. J. Beale. Some biological characteristics of cell lines derived from normal rabbit kidney. J. Path. Bact. 95: 377-381, 1968.
5. Darmoun, D., D. E. Matthews, J.-F. Desjeux, and D. M. Bier. Glutamine and glutamate nitrogen exchangeable pools in cultured fibroblasts: a stable isotope study. J. Cell. Physiol. 134: 143-148, 1988.
6. Fukuhara, Y., and R. J. Turner. Cation dependence on renal outer cortical brush border membrane L-glutamate transport. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17): F869-F875, 1985.
7. Gazzola, G. C., V. Dall'Asta, O. Bussolati, M. Makowske, and H. N. Christensen. A stereo-specific anomaly in dicarboxylic amino acid transport. J. Biol. Chem. 256: 6054-6059, 1981
8. Goldstein, L. Pathways of glutamine deamination and their control in the rat kidney. Am. J. Physiol. 213: 983-989, 1967.
9. Gstruanthaler, G., and J. S. Handler. Isolation, growth, and characterization of a gluconeogenic strain of renal cells. Am. J. Physiol. 250 (Cell Physiol. 19): C232-C238, 1987.
10. 1 cultures: role of transamination. Am. J. Physiol. 263 (Cell Physiol. 32): C47-C54, 1993.
11. Guder, W. G., and U. Schmidt. Substrate and oxygen dependence of renal metabolism. Kidney Int. 10: 532-538, 1976.
12. Handler, J. S., N. Green, and R. E. Steele. Cultures as epithelial models: porous-bottom culture dishes for studying transport and differentiation. Methods Enzymol. 171: 736-744, 1989.
13. Handler, J. S., F. M. Perkins, and J. P. Johnson. Studies of renal cell function using cell culture technique. Am. J. Physiol. 238 (Renal Fluid Electrolyte Physiol. 7): F1-F9, 1980.
14. 1. In Vitro 12: 670-677, 1976.
15. Kanai, Y., and M. A. Hediger. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature Lond. 360: 467-471, 1992.
16. Kozak, E. M., and S. S. Tate. Interaction of the anti-tumor drug, L-α-amino-3-chloro-4,5-dihydro-5-isoxazolacetic acid (AT-125) with renal brush border membranes: specific labeling of γ-glutamyl-transpeptidase. FEBS Lett. 122: 170-175, 1980.
17. Langford, M. P., M. E. Berg, J. H. Mack, J. P. Ganley, and T. C. Welbourne. Inhibition of glutamate uptake causes an acute increase in aqueous humor protein. Exp. Eye Res. In press.
18. 1 renal epithelia to tumor necrosis factor. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F315-F322, 1995.
19. Meister, A., S. S. Tate, and L. L. Ross. Membrane-bound γ-glutamyl-transpeptidase. Enzymes Biol. Membr. 3: 315-347, 1976.
20. + cells to metabolic acidosis. Am. J. Physiol. 270 (Cell Physiol. 39): C920-C925, 1996.
21. Murer, H., A. Leopolder, R. Kinne, and G. Burckhardt. Recent observation on the proximal tubular transport of acidic and basic amino acids by rat renal proximal tubular brush border vesicles. Int. J. Biochem. 12: 223-228, 1980.
22. Orlowski, M., and A. Meister. γ-Glutamyl-p-nitroanilide: a new convenient substrate for determination and study of L- and D-γ-glutamyltranspeptidase activities, Biochem. Biophys. Acta 73: 679-681, 1963.
23. Pitts, R. F., I. A. Pilkington, M. B. MacLeod, and E. Leal-Pinto. Metabolism of glutamine by the intact functioning kidney of the dog. J. Clin. Invest. 51: 557-565, 1972.
24. 1) with characteristics of proximal tubular cells. Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19): F734-F743, 1986.
25. 1). J. Biol. Chem. 258. 2543-2547, 1993.
26. 25a. Shapiro, R. A., R. F. Morehouse, and N. P. Curthoys. Inhibition by glutamate of phosphate-dependent glutamanase of rat kidney. Biochem. J. 207: 561-566, 1982.
27. Silbernagl, S. The renal handling of amino acids and oligopeptides. Physiol. Rev 68: 911-1007, 1988.
28. Solomon, S. Changes in renal glutamate content during development. Miner. Electrolyte Metab. 10: 204-208, 1984.
29. Steele, R. E., J. S. Handler, A. Preston, and J. P. Johnson. A device for sterile measurement of transepithelial electrical parameters of cultured cells. J. Tissue Culture Method 14: 259-263, 1992.
30. Ullrich, K. J., G. Rumrich, and S. Kloss. Sodium dependence of the amino acid transport in the proximal convolution of the rat kidney. Pfluegers Arch. 351: 49-60, 1974.
31. + cells. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E874-E879, 1993.
32. + cells. Am. J. Physiol. 268 (Cell Physiol. 37): C1418-C1424, 1995.