Pharmacokinetics of dacarbazine in the regional perfusion of extremities with melanoma

Journal of Surgical Oncology

Volumn 63, Issue 3, 1996, Pages 148-158

  Didolkar, Mukund S ^a   Jackson, Andre J ^c   Lesko, Lawrence J ^c   Fitzpatrick, J Lawrence ^b   Buda, Barbara S ^b   Johnston, Gerald S ^b   Zech, Loren A ^d  

^a SINAI HOSPITAL OF BALTIMORE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; DACARBAZINE; HUMAN SERUM ALBUMIN TC 99M; HYPOXANTHINE DERIVATIVE; TECHNETIUM 99M;

ARM; ARTICLE; CLINICAL ARTICLE; COMPARTMENT MODEL; DRUG BINDING; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG URINE LEVEL; EXTRACORPOREAL CIRCULATION; HUMAN; HYPERTHERMIC THERAPY; LEG; MELANOMA; PHOTOLYSIS; PRIORITY JOURNAL; REGIONAL PERFUSION;

ANTINEOPLASTIC AGENTS; ARM; DACARBAZINE; DRUG ADMINISTRATION SCHEDULE; HUMANS; HYPERTHERMIA, INDUCED; LEG; MELANOMA; MODELS, BIOLOGICAL; PERFUSION;

EID: 0029826648     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9098(199611)63:3<148::AID-JSO4>3.0.CO;2-D     Document Type: Article

References (19)

1. Chabner BA: DTIC (Dacarbazine). In: Chabner BA (ed): "Pharmacologic Principles of Cancer Treatment." Philadelphia: Saunders, 1982, 350-356.
2. Loo TL, Luce JK, Jardine JH, et al: Pharmacologic studies of the antitumor agent 5-(dimethyltriazeno) imidazole-4-carboxamide. Cancer Res 28:2448-2453, 1968.
3. Breithaupt H, Dammann A, Ainger K: Pharmacokinetics of dacarbazine (DTIC) and its metabolite 5-aminoimidazole-4-carboxamide (AIC) following different dose schedules. Cancer Chemother Pharmacol 9:103-109, 1982.
4. Benvenuto JA, Hall SW, Farquhar D, et al.: High-pressure liquid chromatography in pharmacological studies of anticancer drugs. Chromatogr Sci 10:377-395, 1979.
5. Fiore D, Jackson AJ, Didolkar MS, et al.: Simultaneous determination of dacarbazine, its photolytic degradation product, 2-azahypoxanthine, and the metabolite 5-aminoimidazole-4-carboxamide in plasma and urine by high pressure liquid chromatography. Antimicrob Agents Chemother 27:977-979, 1985.
6. Loo TL, Housholder GE, Gerulath AH, et al.: Mechanism of action and pharmacology studies with DTIC (NSC-45388). Cancer Treat Rep, 60:149-152, 1976.
7. Einhorn LH, McBride CM, Luce JK, et al.: Intra-arterial infusion therapy with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC45388) for malignant melanoma. Cancer 32:749-755, 1973.
8. Savlov ED, Hall TC, Oberfield RA: Intra-arterial therapy of melanoma with dimethyl triazeno imidazole carboxamide (NSC-45388) Cancer 28:1161-1164, 1971.
9. Pfefferkorn RO, Didolkar MS: Regional perfusion for melanoma of the extremities. J. Extra-Corpor Technol 14:475-479, 1982.
10. Didolkar MS, Fitzpatrick JL, Jackson AJ, et al.: Toxicity and complications of vascular isolation and hyperthermic perfusion with imidazole carboxamide (DTIC) in melanoma. Cancer 57:1961-1966, 1986.
11. Ariyan S, Mitchell MS, Kirkwood JM: Isolated perfusion of high risk melanoma of the extremities with imidazole carboxamide. Surg. Gynecol Obstet 158:238-242, 1984.
12. Ainger K, Hild P, Breithaupt H, et. al.: Isolated extremity perfusion with DTIC. An experimental and clinical study. Anticancer Res 3:87-94, 1983.
13. Benckhuijsen C, Varossieau FJ, Hart AA, et al.: Pharmacokinetics of melphalan in isolated perfusion of the limbs. J Pharmacol Exp Ther 237:583-588, 1986.
14. Briele HA, Djuric M, Jung DT, et al.: Pharmacokinetics of melphalan in clinical isolation perfusion of the extremities. Cancer Res 45:1885-1889, 1985.
15. Krementz ET, Carter RD, Sutherland CM, et al.: The use of regional chemotherapy in the management of malignant melanoma. World J Surg 3:289-304, 1979.
16. Stehlin JS, Giovanella BC, de Ipulyi PD, et al.: Results of hyperthermic perfusion in melanoma of the extremities. Surg Gynecol Obstet 140:338-348, 1975.
17. Gerlowski LE, Jain RK: Physiologically based pharmacokinetic modeling: Principles and application. J Pharm Sci 72:1103-1127, 1983.
18. Goresky CA and Rose CP: Blood-tissue exchange in liver and heart: the influence of heterogeneneity of capillary transit times. Fed Proc 36:2629-2634, 1977.
19. Boston RC, Greif PC, Berman M: Conversational SAAM-An inter-active program for kinetic analysis of biological systems. Comput Programs Biomed 13:111-119, 1981.