Sequences within the first exon of BCR inhibit the activated tyrosine kinases of c-Abl and the Bcr-Abl oncoprotein

Cancer Research

Volumn 56, Issue 22, 1996, Pages 5120-5124

  Liu, Jiaxin ^a   Wu, Yun ^a   Arlinghaus, Ralph B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL GROWTH; CONTROLLED STUDY; DNA TRANSFECTION; EXON; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA; NONHUMAN; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; COS CELLS; ENZYME ACTIVATION; EXONS; FUSION PROTEINS, BCR-ABL; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-BCR; SRC HOMOLOGY DOMAINS;

EID: 0029826506     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Konopka, J. B., Watanabe, S M., and Witte, O. N. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell, 37: 1035-1042, 1984.
2. Kloetzer, W., Kurzrock, R., Smith, L., Talpaz, M. Spiller, M., Gutterman, J., and Arlinghaus, R. B. The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity. Virology, 110, 230-238, 1985.
3. bcr/abl gene of the Philadelphia chromosome. Science (Washington DC), 247: 824-830, 1990.
4. Heisterkamp, N., Jenster, G , ten Hoeve, J , Zovich, D , Pattengale, P. K., and Groffen, J. Acute leukemia in BCR-ABL transgenic mice. Nature (Lond), 344: 251-253, 1990
5. Franz, W. M , Berger, P., and Wang, J. Y. J. Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential EMBO J , 8, 137-147, 1989
6. Mayer, B J., Jackson, P. K , VanEtten, R A., and Baltimore, D Point mutations in the Abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo Mol. Cell. Biol., 12: 609-618, 1992
7. Campbell, M., Li, W., and Arlinghaus, R. B. P210 BCR-ABL is complexed to P160 BCR and ph-P53 proteins in K562 cells. Oncogene. 5: 773-776, 1990.
8. Lu, D , Liu, J., Campbell, M., Guo, J. Q , Heisterkamp, N., Groffen, J., Canaani, E , and Arlinghaus, R. B. Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL. Blood, 82: 1257-1263, 1993.
9. Liu, J., Campbell, M., Guo, J Q , Lu, D., Xian, Y M. and Arlinghaus, R B BCR-ABL tyrosine kinase autophosphorylates itself or transphosphorylates P160 BCR on tyrosine predominantly within the first exon. Oncogene. 8: 101-109, 1993.
10. Liu, J., Wu, Y., Ma, G , Lu, D., Haataja, L., Heisterkamp, N , Groffen, J , and Arlinghaus, R. B. Inhibition of Bcr serine kinase by tyrosine phosphorylation. Mol. Cell. Biol , 16: 998-1005, 1996.
11. Maru, Y , and Witte, O. N The BCR gene encodes a novel serine/threonine kinase activity within a single exon. Cell. 67: 459-468, 1991.
12. Pendergast, A M. Muller, A J , Havlik, M H., Maru, Y., and Witte, O. N BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell, 66 161-171, 1991
13. McWhirter, J. R., Galasso, D. L., and Wang, J Y. J. A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins Mol Cell. Biol , 13: 7587-7595, 1993.
14. Garcia, R A., Saya, H., and Gallick, G E. Effect of Herbamycin A on growth and pp60 cc-Src activity in human colon tumor cell lines. Oncogene, 6: 1983-1989, 1991.
15. Pendergast, A. M., Muller, A J., Havlik, M. H., Clark, R., McCormick, F., and Witte, O. N. Evidence for regulation of the ABL tyrosine kinase by a cellular inhibitor. Proc. Natl. Acad. Sci. USA., 88: 5927-5931, 1991.
16. Puil, L., Liu, J., Gish, G., Mbalamu, G., Arlinghaus, R , Pelicci, P. G., and Pawson, T. BCR-ABL oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J., 13: 764-773, 1994.
17. Pendergast, A M , Quilliam, L A., Cripe, L D , Bassing, C. H , Dai, Z , Li, N., Batzer, A., Rabun, K M , Der, C. J., Schlessinger, J , and Gishizky, M. L BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell, 75: 175-185, 1993