Integrins and disease

Clinical Science

Volumn 91, Issue 6, 1996, Pages 639-650

  Hillis, Graham S ^a   Macleod, Alison M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cell adhesion; Integrins; Molecules

Indexed keywords

CADHERIN; IMMUNOGLOBULIN; INTEGRIN; MATRIX PROTEIN; MEMBRANE PROTEIN; SELECTIN;

CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; GENERAL ASPECTS OF DISEASE; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW;

EID: 0029826442     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0910639     Document Type: Review

References (100)

1. Hynes RO. Integrins, a family of cell surface receptors. Cell 1987; 48: 549-54.
2. Ruoslahti E. Integrins. J Clin Invest 1991; 87: 1-5.
3. Buck CA, Horwitz AF. Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 1987; 3: 179-205.
4. Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 1990; 4: 2868-80.
5. Ruoslahti E, Pierschbacher MD. Arg-Gly-Asp; a versatile cell recognition signal. Cell 1986; 44: 517-18.
6. Springer TA. Adhesion receptors of the immune system. Nature (London) 1990; 346: 425-34.
7. Ferrell JE, Martin GS. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc Natl Acad Sci USA 1989; 86: 2234-8.
8. 3 for angiogenesis. Science (Washington DC) 1994; 264: 569-71.
9. Savill J, Dransfield I, Hogg N, Haslett N. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature (London) 1990; 343: 170-3.
10. v integrins. Science (Washington DC) 1995; 270: 1500-2.
11. Hemler ME. VLA proteins in the integrin family: structures, functions and their role on leukocytes. Annu Rev Immunol 1990; 8: 365-400.
12. Hynes RO. Integrins: versatility, modulation and signaling in cell adhesion. Cell 1992; 69: 11-25.
13. Humphries MJ. Peptide recognition motifs involved in the binding of integrins to their ligands. Kidney Int 1992; 41: 645-9.
14. Burridge K, Fath K, Kelly T, Nuckolls G, Turner C. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 1988; 4: 487-525.
15. Hibbs ML, Xu H, Stacker SA, Springer TA. Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin β subunit. Science (Washington DC) 1991; 251: 1611-13.
16. O'Toole TE, Loftus JC, Plow EF, Glass AA, Harper JR, Ginsberg MH. Efficient surface expression of platelet GPIIb-IIIa requires both subunits. Blood 1989; 74: 14-18.
17. Akiyama SK, Yamada KM. Biosynthesis and aquisition of biological activity of the fibronectin receptor. J Biol Chem 1987; 262: 17536-42.
18. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996; 84: 345-7.
19. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995; 57: 827-72.
20. Smyth SS, Joneckis CC, Parise LV. Regulation of vascular integrins. Blood 1993; 81: 2827-43.
21. Adams DH, Shaw S. Leukocyte-endothelial interactions and regulation of leukocyte migration. Lancet 1994; 343: 831-6.
22. Haralson MA. Extracellular matrix and growth factors: an integrated interplay controlling tissue repair and progression to disease. Lab Invest 1993; 69: 369-72.
23. Ruoslahti E. Integrins as receptors for extracellular matrix. In: Hay ED, ed. Cell biology of extracellular matrix. New York: Plenum Press, 1991: 343-63.
24. Ignotz RA, Massague J. Cell adhesion protein receptors as targets for transforming growth factor-β action. Cell 1987; 51: 189-97.
25. 1 and by platelet-derived-growth factor-BB. J Cell Physiol 1992; 151: 588-95.
26. Ruoslahti E, Noble N, Kagami S, Border WA. Integrins. Kidney Int 1994; 45 (Suppl. 44): S17-22.
27. 1-integrin on the glomerular capillary wall: an immunfluorescence study in nephrotic syndrome. Nephron 1992; 62: 382-8.
28. Dal Canton A. Adhesion molecules in renal disease. Kidney Int 1995; 48: 1687-96.
29. 1 integrins and transforming growth factor-β-induced matrix proteins in glomerulonephritis. Lab Invest 1993; 69: 68-76.
30. Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994; 331: 1286-92.
31. Kanahara K, Yorioka N, Arita M, Ohira N, Yamakido M. Immunohistochemical studies of extracellular matrix components and integrins in IgA nephropathy. Nephron 1994; 66: 29-37.
32. Hillis G, Roy-Chaudhury P, Duthie L, et al. Changes in VLA integrin expression in mesangioproliferative glomerulonephritis. J Am Soc Nephrol 1995; 6: 896 [Abstract].
33. 3 integrin upregulation in rapidly progressive glomeronephritis. Nephrol Dial Transplant 1995; 10: 1155-61.
34. Mendrick DL, Kelly DM, DuMont SS, Sandstrom DJ. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Lab Invest 1995; 72: 367-75.
35. Roy-Chaudhury P, Wu B, King G, et al. Adhesion molecule interactions in human glomerulonephritis: importance of the tubulointerstitium. Kidney Int 1996; 49: 127-34.
36. Brady HR. Leukocyte adhesion molecules and kidney diseases. Kidney Int 1994; 45: 1285-300.
37. Cosimi AB, Conti D, Delmonico FL, et al. In vivo effects of monoclonal antibody to ICAM-1 (CD 54) in nonhuman primates with renal allografts. J Immunol 1990; 144: 4604-12.
38. Haug CE, Colvin RB, Delmonico FL, et al. A phase 1 trial of immunosuppression with anti-ICAM-1 (CD 54) mAb in renal allograft recipients. Transplantation 1993; 55: 766-73.
39. Fischer A, Blanches S, Veber F, et al. Prevention of graft failure by an anti-LFA-1 monoclonal antibody in HLA-mismatched bone marrow transplantation. Lancet 1986; ii: 1058-61.
40. Le Mauff B, Hourmant M, Rougier J-P, et al. Effect of anti-LFA-1 (CD 11a) monoclonal antibodies in acute rejection in human kidney transplantation. Transplantation 1991; 52: 291-6.
41. Liaw L, Skinner MP, Raines EW, et al. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. J Clin Invest 1995; 95: 713-24.
42. 1 integrin is required for chemotaxis across type 1 collagen-coated membranes. Am J Pathol 1994; 145: 1070-81.
43. Boureau N, Turley E, Rabinovitch M. Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration. Dev Biol 1991; 143: 235-47.
44. Jang Y, Lincoff AM, Plow EF, Topol EJ. Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol 1994; 24: 1591-601.
45. Ross R, Raines EW, Bowen-Pope DF. The biology of platelet derived growth factor. Cell 1986; 46: 155-69.
46. 1-integrin function in cultured human vascular smooth muscle cells. Circ Res 1996; 78: 596-605.
47. 3 integrin expression in normal and atherosclerotic artery. Circ Res 1995; 77: 1129-35.
48. Simoons ML, de Boer MJ, van den Brand MJBM, et al. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. Circulation 1994; 89: 569-603.
49. Topol EJ, Califf RM, Weisman HF, et al. Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet 1994; 343: 881-6.
50. Fan ST, Edington TS. Coupling the adhesive receptor CD11b/CDI8 to functional enhancement of effector macrophage tissue factor response. J Clin Invest 1991; 87: 50-7.
51. Altieri DC, Edington TS. The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. J Biol Chem 1988; 263: 7007-15.
52. Volpes R, van den Oord JJ, Desmet VJ. Distribution of the VLA family of integrins in normal and pathological liver tissue. Gastroenterology 1991; 101: 200-6.
53. Choy MY, Richman PI, Norton MA, MacDonald TT. Expression of the VLA family of integrins in human intestine J Pathol 1990; 160: 35-40.
54. Nakamura S, Ohtani H, Watanabe Y, et al. In situ expression of the cell adhesion molecules in inflammatory bowel disease. Lab Invest 1993; 69: 77-85.
55. Jaskiewicz K, Chasen MR. Differential expression of transforming growth factor alpha, adhesion molecules and integrins in primary, metastatic tumors and in liver cirrhosis. Anticancer Res 1995; 15: S59-62.
56. Iredale JP, Arthur MJP. Hepatocyte-matrix interactions. Gut 1994; 35: 729-32.
57. Stamatoglou SC, Hughes RC. Cell adhesion molecules in liver function and pattern formation. FASEB J 1994; 8: 420-7.
58. Gaffen JD. Interaction between the cell surface and the extracellular matrix. Br J Rheumatol 1992; 31: 74-6.
59. Steinhoff G, Behrend M, Scharder B, Pichlmayr R. Intercellular immune adhesion molecules in human liver transplants: overview on expression patterns of leukocyte receptor and ligand molecules. Hepatology 1993; 18: 440-53.
60. Volpes R, van den Oord JJ, Desmet VJ. Immunohistochemical study of adhesion molecules in liver inflammation. Hepatology 1990; 12: 59-65.
61. 1 in human and experimental lung granulomatous inflammation. Am J Med Sci 1995; 309: 124-33.
62. Fukuda Y, Basset F, Ferrans VJ, Yamanaka N. Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis. Hum Pathol 1995; 26: 53-61.
63. Piguet PF, Rosen H, Vesin C, Grau GE. Effective treatment of the pulmonary fibrosis elicited by bleomycin or silica with anti-CD11 antibodies. Am Rev Respir Dis 1993; 147: 435-41.
64. Albelda SM. The role of cell adhesion molecules in asthma - an overview. Agents Actions 1993; 43 (Suppl.): 141-50.
65. Chihara J, Yamamoto T, Kurachi D, Kakazu T, Higashimoto I, Nakajima S. Possible release of eosinophil granule proteins in response to signaling from intercellular adhesion molecule-1 and its ligands. Int Arch Allergy Immunol 1995; 108 (Suppl. 1): 52-4.
66. Metzger WJ. Therapeutic approaches to asthma based on VLA-4 integrin and its counter receptors. Springer Semin Immunopathol 1995; 16: 467-78.
67. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science (Washington DC) 1990; 247: 456-9.
68. Gundel RH, Wegner CD, Torcellini CA, et al. Endothelial leucocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys. J Clin Invest 1991; 88: 1407-11.
69. Gruschwitz M, von den Driesch P, Kellner I, Hornstein OP, Sterry W. Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis. J Am Acad Dermatol 1992; 27: 169-77.
70. 2 integrins, intercellular adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset. Arthritis Rheum 1992; 35: 290-8.
71. Andrew SM, Edwards BD, Chalmers RJG, O'Driscoll JB. A quantitative immunohistochemical study of the expression of integrins by nerves in psoriatic and normal skin. Br J Dermatol 1992; 127: 359-64.
72. 4 integrins in lesional and non-lesional skin in bullous pemphigoid. Br J Dermatol 1992; 127: 103-11.
73. Savoia P, Novelli M, Fierro MT, Cremona O, Marchisio PC, Bernengo MG. Expression and role of integrin receptors in Sezary syndrome. J Invest Dermatol 1992; 99: 151-9.
74. Gailit JO, Clark RAF. Integrins. Adv Dermatol 1993; 8: 129-52.
75. 1, stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds. J Invest Dermatol 1994; 103: 221-7.
76. Morelli JG, Yohn JJ, Zekman T, Norris DA. Melanocyte movement in vitro: role of matrix proteins and integrin receptors. J Invest Dermatol 1993; 101: 605-8.
77. Hughes DE, Salter DM, Dedhar S, Simpson R. Integrin expression in human bone. J Bone Miner Res 1993; 8: 527-33.
78. Clover J, Dodds RA, Gowen M. Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. J Cell Sci 1992; 103: 267-71.
79. Horton MA, Rodan GA. Integrins as therapeutic targets in bone disease. In: Horton MA, ed. Adhesion receptors as therapeutic targets. Boca Raton, FL, U.S.A.: CRC Press, 1995: 223-45.
80. Heinegard D, Andersson G, Reinholt FP. Roles of osteopontin in bone remodelling. Ann NY Acad Sci 1995; 760: 213-22.
81. 3. J Biol Chem 1993; 268: 1456-61.
82. 1-integrin levels. Endocrinology (Baltimore) 1995; 136: 598-608.
83. Wahl SM, Allen JB, Hines KL, et al. Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J Clin Invest 1994; 94: 655-62.
84. Sobel RA, Chen M, Maeda A, Hinojoza JR. Vitronectin and integrin vitronectin receptor localization in multiple sclerosis lesions. J Neuropathol Exp Neurol 1995; 54: 202-13.
85. 1 integrin interactions. Am J Pathol 1994; 144: 27-40.
86. 1 integrin. Nature (London) 1992; 356: 63-6.
87. Staunton DE, Dustin ML, Erickson HP, Springer TA. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinoviruses. Cell 1990; 61: 243-54.
88. Ockenhouse CF, Betageri R, Springer TA, Staunton DE. Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Cell 1992; 68: 63-9.
89. Hildreth JE, Orentas RJ. Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. Science (Washington DC) 1989; 244: 1075-8.
90. Gustafson KS, Vercellotti GM, Bendel CM, Hostetter MK. Molecular mimicry in Candida albicons: role of an integrin analogue in adhesion of the yeast to human endothelium. J Clin Invest 1991; 87: 1896-902.
91. Isberg RR. Discrimination between intracellular uptake and surface adhesion of bacterial pathogens. Science (Washington DC) 1991; 252: 934-8.
92. Pottratz ST, Weir AL, Wisniowski PE. Pneumocystis carinii attachment increases expression of fibronectin-binding integrins on cultured lung cells. Infect Immun 1994; 62: 5464-9.
93. Saukkonen K, Cabellos C, Burroughs M, Prasad S, Tuomanen E. Integrin-mediated localization of Bordetello pertussis within macrophages: role in pulmonary colonization. J Exp Med 1991; 173: 1143-9.
94. Albelda SM. Role of integrins and other cell adhesion molecules in tumour progression and metastasis. Lab Invest 1993; 68: 4-17.
95. v gene expression in human melanoma tumorigenicity. J Clin Invest 1992; 89: 2018-22.
96. Schreiner C, Fisher M, Hussein S, Juliano RL. Increased tumorigenicity of fibronectin receptor deficient Chinese hamster ovary cell variants. Cancer Res 1991; 51: 1738-40.
97. 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 1990; 60: 849-59.
98. 1 integrin receptor in malignancy. Invasion Metastasis 1995; 14: 87-97.
99. Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science (Washington DC) 1986; 233: 467-9.
100. Chan BMC, Matsuura N, Takada Y, Zetter BR, Hemler ME. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science (Washington DC) 1991; 251: 1600-2.