Use of site-specified tritium labelling to confirm the formation of 17-oxosparteine as a minor urinary metabolite of sparteine in man

Xenobiotica

Volumn 26, Issue 9, 1996, Pages 977-982

  Ritchie, J C ^a,b   Mitchell, S C ^a   Smith, R L ^a   Zhang, A Q ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; SPARTEINE; TRITIUM;

ADULT; ARTICLE; DRUG SYNTHESIS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; URINARY EXCRETION;

TRITIUM;

EID: 0029826313     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609052499     Document Type: Article

References (22)

1. AHRENS, F. B., 1891, Zur Kenntniss des Sparteïns. Berichte der Deutschen chemischen Gesellschaft, 24, 1095-1097.
2. BARNSLEY, E. A., THOMPSON, A. E. R. and YOUNG, L., 1964, Biochemical studies of toxic agents. The biosynthesis of ethylmercapturic acid and sulphoxide. Biochemical Journal, 90, 588-596.
3. BINNIG, VON F., 1974, Zur Chemie des Sparteins. Arzneimittel-Forschung (Drug Research), 24, 752-753.
4. BOHLMANN, F., 1958, Lupinen-Alkaloide, VIII. Zur Konfigurationsbestimmung von Chinolizidin-Derivaten. Chemische Berichte, 91, 2157-2167.
5. 15-Lupinen-Alkaloide. Chemische Berichte, 90, 653-663.
6. 13C NMR-Spektren von Lupinen-Alkaloiden. Chemische Berichte, 108, 1043-1051.
7. BRAZEAU, P., 1965, The Pharmacological Basis of Therapeutics (New York: Macmillan), pp. 886-887.
8. CHO, Y. D. and MARTIN, R. O., 1971, Resolution and unambiguous identification of microgram amounts of 22 lupin alkaloids by sequential use of thin-layer and gas-liquid chromatography and mass spectrometry. Analytical Biochemistry, 44, 49-57.
9. CLEMO, G. R., MORGAN, W.McG. and RAPER, R., 1936, The lupin alkaloids. Part X. The synthesis of dl-oxysparteine. Journal of the Chemical Society, 1025-1028.
10. CLEMO, R. R. and RAPER, R., 1929, The lupin alkaloids. Part II. Journal of the Chemical Society, 1927-1940.
11. CLEMO, G. R., RAPER, R. and SHORT, W. S., 1949, The lupin alkaloids. Part XIV. Journal of the Chemical Society, 663-665.
12. EICHELBAUM, M., REETZ, K. P., SCHMIDT, E. K. and ZEKORN, C., 1986. The genetic polymorphism of sparteine metabolism. Xenobiotica, 16, 465-481.
13. EICHELBAUM, M., SPANNBRUCKER, N. and DENGLER, H. J., 1975, N-oxidation of sparteine in man and its interindividual differences. Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 287 (suppl. P), R94.
14. ELLIOTT, D. C., 1959, Methods for the detection of biochemical compounds on paper. In Data for Biochemical Research, edited by R. M. C. Dawson, D. C. Elliott, W. H. Elliott and K. M. Jones (London: Clarendon), pp. 210-272.
15. MCLAFFERTY, F. W. and STAUFFER, D. B., 1989, The Wiley/NBS Registry of Mass Spectral Data (New York: Wiley).
16. NEWTON, B. W., BENSON, R. C. and MCCARRISTON, C. C., 1966, Sparteine sulfate: a potent, capricious oxytocic. American Journal of Obstetrics and Gynecology, 94, 234-241.
17. PATTERSON, M. S. and GREENE, R. C., 1965, Measurement of low energy beta-emitters in aqueous solution by liquid scintillation counting of emulsions. Analytical Chemistry, 37, 584-587.
18. PETERSON, J. L., WAGNER, F., SIEGEL, S. and NIXON, W., 1969, A system for convenient combustion preparation of tritiated biological samples for scintillation analysis. Analytical Biochemistry, 31, 189-203.
19. POSPÍSIL, J., PATZELOVÁ, V. and MÁCA, B., 1992, New evidence of sparteine metabolites in humans. Drug Metabolism and Disposition, 20, 330-332.
20. PRICE-EVANS, D. A. P., 1993, Genetic Factors in Drug Therapy (Cambridge: Cambridge University Press), pp. 54-101.
21. RASCHACK, M., 1974, Wirkungen von Spartein und Sparteinderivaten auf Herz und Kreislauf. Arzneimittel-Forschung (Drug Research), 24, 753-761.
22. WINK, M., WITTE, L. and HARTMANN, T., 1981, Quinolizidine alkaloid composition of plants and of photomixotrophic cell suspension cultures of Sarothamnus scoparius and Orobanche rapumgenistae. Planta Medica, 43, 342-352.