Suppression of herpes simplex virus infections with oral lithium carbonate - A possible antiviral activity

Pharmacotherapy

Volumn 16, Issue 6 I, 1996, Pages 1070-1075

  Amsterdam, Jay D ^a,b,c   Maislin, Greg ^a   Hooper, Mary B ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c The Science Center Philadelphia   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; DEOXYGLUCOSE; LITHIUM CARBONATE; SUCCINATE LITHIUM; VIRUS DNA;

ADULT; AGED; ANTIVIRAL ACTIVITY; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; HERPES SIMPLEX VIRUS; HUMAN; MALE; ORAL DRUG ADMINISTRATION; POLYDIPSIA; POLYURIA; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; VIRUS CULTURE; VIRUS INFECTION; VIRUS REPLICATION;

ADULT; AGED; ANTIVIRAL AGENTS; DOUBLE-BLIND METHOD; FEMALE; HERPES SIMPLEX; HUMANS; LITHIUM CARBONATE; MALE; MIDDLE AGED; POLYURIA;

EID: 0029825407     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bach RO, Specter S. Antiviral activity of the lithium ion with adjuvant agents. In: Birch NJ, ed. Lithium: inorganic pharmacology and psychiatric use. Oxford: IRL Press Ltd, 1988:91-2.
2. Buchan A, Randall S, Hartley CE, Skinner GRB, Fuller A. Effect of lithium salts on the replication of viruses and non-viral microorganisms. In: Birch NJ, ed. Lithium: inorganic pharmacology and psychiatric use. Oxford: IRL Press Ltd, 1988:83-92.
3. Skinner GRB, Hartley C, Buchan A, Harper L, Gallimore P. The effects of lithium chloride on the replication of herpes simplex virus. Med Microbiol Immunol 1980;168:139-48.
4. Ziaie Z, Kefalides NA. Lithium chloride restores host protein synthesis in herpes simplex virus infected endothelial cells. Biochem Biophys Res Comm 1989;160:1073-8.
5. Ziaie Z, Brinker JM, Kefalides NA. Lithium chloride suppressed the synthesis of messenger RNA for infected cell protein-4 and viral deoxyribonucleic acid polymerase in herpes simplex virus infected endothelial cells. Laboratory Investigation 1994;70:29-38.
6. Hartley CE. The effect of lithium on herpes simplex virus replication. Med Lab Sci 1983;40:406.
7. Patou G, Crow TJ, Taylor GR. The effects of psychotropic drugs on synthesis of DNA and the infectivity of herpes simplex virus. Biol Psychiatry 1986;21:1221-5.
8. Gilis A. Lithium in herpes simplex. Lancet 1983;2:1209-10.
9. Lieb J. Remission of recurrent herpes infection during therapy with lithium. N Engl J Med 1979;301:942.
10. Amsterdam JD, Maislin G, Rybakowski J. Possible ami-viral action of lithium carbonate in herpes simplex virus infections. Biol Psychiatry 1990;27:447-53.
11. Amsterdam JD, Maislin G, Potter L, Giuntoli R, Koprowski H. Suppression of recurrent genital herpes infections with lithium carbonate: a randomized, placebo-controlled study. Lithium 1991;2:17-25.
12. Amdisen A. Monitoring lithium dose levels: clinical aspects of serum lithium estimation. In: Johnson FN, ed. Handbook of lithium therapy. Baltimore: University Park Press, 1980:179-95.
13. Feldman HA. Families of lines: random effects I linear regression analysis J Applied Physiol 1988;64:1721-32.
14. Cohen J. Statistical power analysis for the behavioral sciences. New York: Academic Press, 1969:22-5.
15. Skinner GRB. Lithium ointment for genital herpes. Lancet 1983;2:288.
16. Friedenberg WR, Marx JJ. The effect of lithium carbonate on lymphocyte, granulocyte, and platelet function. Cancer 1980;45:91-7.
17. Shenkman L, Borkowsky W, Holzman RS, Shopsin B. Enhancement of lymphocyte and macrophage function in vitro by lithium chloride. Clin Immunol Immunopathol 1987;10:187-92.
18. Horrobin DF. Lithium in the control of herpes virus infections. In: Bach RO, ed. Lithium: current applications in science, medicine, and technology. New York: John Wiley & Sons, 1980:397-406.
19. Horrobin DF, Jenkins DK, Mitchell J, Manku MS. Lithium effects on essential fatty acid and prostaglandin metabolism. In: Birch NJ. ed. Lithium: inorganic pharmacology and psychiatric use. Oxford: IRL Press Ltd, 1988:173-6.
20. Bohn W, Rutter G, Hohenberg H, Mannweller K. Inhibition of measles virus budding by phenothiazines. Virology 1983;130:44-55.
21. Gosztonyi G, Ludwig H. Neurotransmitter receptors and viral neurotropism. Neuropsychiatr Clin 1984;3:107-14.
22. Shaskan EG, Oreland L, Wadell G. Dopamine receptors and monoamine oxidase as virion receptors. Perspect Biology Med 1985;27:239-50.
23. Rybakowski J, Amsterdam JD. Lithium prophylaxis and recurrent labial herpes infections. Lithium 1991;2:43-7.
24. DePaulo JR, Jr, Correa EI, Sapir DG. Renal glomerular function and long-term lithium therapy. Am J Psychiatry 1981;138:324-7.
25. Vestergaard P, Amdisen A. Lithium treatment and kidney function: a follow-up study of 237 patients in long-term treatment. Acta Psychiat Scand 1981;63:333-45.
26. Jorkasky DK, Amsterdam JD, Oler J, Braden G, Alvis R, Geheb M, Cox M. Lithium-induced renal disease: a prospective study. Clin Nephrol 1988;30:293-302.
27. Glaser R, Kiecolt-Glaser JK, Speicher CE, Holliday JE. Stress, loneliness, and changes in herpesvirus latency. J Behav Med 1985;8:249-60.
28. Landmann RMA, Muller FB, Perini CH, Wesp M, Erne P, Buhler FR. Change in immunoregulatory cells induced by psychological and physical stresses: relationship to plasma catecholamincs. Clin Experiment Immunol 1984;58:127-35.