Further characterization of cytotoxic T cells generated by short-term culture of human peripheral blood lymphocytes with interleukin-2 and anti-CD3 mAb

Cancer Immunology Immunotherapy

Volumn 42, Issue 6, 1996, Pages 369-375

  Jacobs, Nathalie ^a   Greimers, Roland ^a   Mazzoni, Alessandra ^b   Trebak, Mohamed ^a   Schaaf Lafontaine, Nicole ^a   Boniver, Jacques ^a   Moutschen, Michel P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Activation; Anti CD3 mAb; Bispecific antibody; Fc receptor (Fc R); Redirected cytotoxicity

Indexed keywords

BISPECIFIC ANTIBODY; CD3 ANTIGEN; CD45 ANTIGEN; FC RECEPTOR; HLA DR ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; OKT 3;

ADULT; ARTICLE; CANCER CELL DESTRUCTION; CELL LINE; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NORMAL HUMAN; OVARY TUMOR; PHENOTYPE; PRIORITY JOURNAL;

ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; PHENOTYPE; STIMULATION, CHEMICAL; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS;

EID: 0029825071     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050296     Document Type: Article

References (65)

1. Allavena P, Damia G, Colombo T, Maggioni D, D'Incalci M, Mantovani A (1989) Lymphokine-activated killer (LAK) and monocyte-mediated cytotoxicity on tumor cell lines resistant to antitumor agents. Cell Immunol 120:250
2. Anderson CL (1989) Structural and functional polymorphism of human Fc receptor for IgG. Chem Immunol 47:1
3. Anderson PM, Crist W, Hasz D, Carroll AJ, Myers DE, Uckun FM (1992) G19.4 (αCD3) × B43 (αCD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells. Blood 80:2826
4. Anderson PM, Ochoa AC, Ramsay NK, Hasz D, Weisdorf D (1992) Anti-CD3 + interleukin-2 stimulation of marrow and blood: comparison of proliferation and cytotoxicity. Blood 80:1846
5. Azuma A, Yagita H, Okumura K, Kudoh S, Niitani H (1994) Potentiation of long-term-cultured lymphokine-activated killer cell cytotoxicity against small-cell lung carcinoma by anti-CD3 × anti-(tumor-associated antigen) bispecific antibody. Cancer Immunol Immunother 38:294
6. Bolhuis RLH, Lamers CHJ, Goey SH, Eggermont AMM, Trimbos JBMZ, Stoter G, Lanzavecchia A, di Re E, Miotti S, Raspagliesi F, Rivoltini L, Colnaghi MI (1992) Adoptive immunotherapy of ovarian carcinoma with BS-MAb-targeted lymphocytes: a multicenter study. Int J Cancer Suppl 7:78
7. Cesano A, Visonneau S, Clark SC, Santoli D (1993) Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12. J Immunol 151:2943
8. Chehimi J, Valiante NM, D'Andrea A, Rengaraju M, Rosado Z, Kobayashi M, Perussia B, Wolf SF, Starr SE, Trinchieri G (1993) Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur J Immunol 23:1826
9. Chiaffarino F, Biffi M, Luciano A, Gromo G, Leoni F (1994) Involvement of multiple protein kinases in CD3-mediated activation of human T lymphocytes. Cell Immunol 153:39
10. Chong A S-F, Aleksijevic A, Seuderi P, Hersh EM, Grimes WJ (1989) Phenotypic and functional analysis of lymphokine-activated killer (LAK) cell clones. Ability of CD3+, LAK cell clones to produce interferon-γ and tumor necrosis factor upon stimulation with tumor targets. Cancer Immunol Immunother 29:270
11. Chong AS-F, Boussy IA, Graf LH, Scuderi P (1992) Stimulation of IFN-γ, TNF-α, and TNF-β secretion m IL-2-activated T cells: costimulatory roles for LFA-1, LFA-2, CD44, and CD45 molecules. Cell Immunol 144:69
12. Chong AS-F, Staren ED, Scuderi P (1992) Monoclonal antibodies anti-CD3, anti-TCR αβ and anti-CD2 act synergistically with tumor cells to stimulate lymphokine-activated killer cells and tumor infiltrating lymphocytes to secrete interteron γ. Cancer Immunol Immunother 35:335
13. Colamonici OR, Quinones R, Rosolen Am Trepel JBm Sausville E, Phares JC, Gress R, Poplack D, Weber J, Schechter GP, Neckers LM (1988) The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes. Blood 71:825
14. Collins SJ, Gallo RC, Gallagher RE (1977) Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 270:347
15. Davis L, Vida R, Lipsky PE (1986) Regulation of human T lymphocyte mitogenesis by antibodies to CD3. J Immunol 137:3758
16. Dohi Y, Sunada S, Aoki M, Moriguchi A, Okabayashi M, Miyata M and Matsuda H (1993) Eradication of metastatic tumour cells from lymph nodes by local adminstration of anti-CD3 antibody. Cancer Immunol Immunother 36:357
17. Ferran C, Sheehan K, Dy M, Schreiber R, Merite S, Landais P, Noel L-H, Grau G, Bluestone J, Bach J-F, Chatenoud L (1990) Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation. Eur J Immunol 20:509
18. Ferrini S, Sforzini S, Cambiaggi A, Poggi A, Meazza R, Canevari S, Colnaghi MI, Moretta L (1994) The LFA-1/ICAM cell adhesion pathway is involved in tumor-cell lysis mediated by bispecific monoclonal-antibody-targeted T lymphocytes. Int J Cancer 56:846
19. Flamand V, Abramowicz D, Goldman M, Biernaux C, Huez G, Urbain J, Moser M, Leo O (1990) Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 bold in vitro and in vivo. J Immunol 144:2875
20. Garrido MA, Valdayo MJ, Winkler DF, Titus JA, Hecht TT, Perez P, Segal DM, Wunderlich JR (1990) Targeting human T-lymphocytes with bispecific antibodies to react against human ovarian carcinoma cells growing in nu/nu mice. Cancer Res 50:4227
21. Geller RL, Smyth MJ, Strobl SL, Bach FH, Ruscetti FW, Longo DL, Ochoa AC (1991) Generation of lymphokine-activated killer activity in T cells. Possible regulatory circuits. J Immunol 146:3280
22. Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersley JH, Dosik H, Parks WP (1973) In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 51:1417
23. Gilles C, Piette J. Rombouts S, Laurent C, Foidart J-M (1993) Immortalization of human cervical keratinocytes by human papillomavirus type 33. Im J Cancer 53:872
24. Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA (1982) Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin-2 activated autologous human peripheral blood lymphocytes. J Exp Med 155:1832
25. Hamilton TC, Young RC, Louie KG, Behrens BC, McKoy WM, Grotzinger KR, Ozols RF (1984) Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice. Cancer Res 44:5286
26. Hermann GG, Petersen KR, Steven K, Zeuthen J (1990) Reduced LAK cytotoxicity of peripheral blood mononuclear cells in patients with bladder cancer: decreased LAK cytotoxicity caused by a low incidence of CD56+ and CD57+ mononuclear blood cells. J Clin Immunol 10:311
27. Hurwitz R, Hozier J, Lebien T, Minowada J, Gajl-Peczalska K, Kubonishi I, Kersey J (1979) Characterization of a leukemic cell line of the pre-B phenotype. Im J Cancer 23:174
28. Itoh K, Tilden AB, Balch CM (1986) Lysis of human solid tumor cells by lymphokine-activated natural killer cells. J Immunol 136:3910
29. Jacobs N, Moutschen MP, Boniver J, Greimers R, Schaaf-Lafontaine N (1993) Efficient immunoselection of cytolytic effectors with a magnetic cell sorter. Res Immunol 144:141
30. Klein E, Klein G, Nadkarni JS Nadkarni JJ, Wigzell H, Clifford P (1968), Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines. Cancer Res 28:1300
31. Lamers CHJ, Griend RJ van de, Braakman E, Ronteltap CPM, Bénard J, Stoter G, Gratama JW, Bolhuis RLH (1992) Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for bispecific antibody-directed cellular immunotherapy. Int J Cancer 51:973
32. Lancki DW, Hsieh C-S, Fitch FW (1991) Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes. J Immunol 146:3242
33. Leeuwenberg JFM, Spits H, Tax WJM, Capel PJA (1985) Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. J Immunol 134:3770
34. Liu C-C, Rafii S, Granelli-Piperno A, Trapani JA, Young JD-E (1989) Perform and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J Exp Med 170:2105
35. Lozzio CB, Lozzio BB (1975) Human chronic myelogenous leukaemia cell-line with positive Philadelphia chromosome. Blood:45:321
36. Mezzanzanica D, Canevari S, Ménard S, Pupa SM, Tagliabue E, Lanzavecchia A, Colnaghi MI (1988) Human ovarian carcinoma lysis by cytotoxic T cells targeted by bispecific monoclonal antibodies: analysis of antibody components. Int J Cancer 41:609
37. 2 antibody prolong host survival in a murine xenograft model. Cancer Res 51:5716
38. Miltenyi S, Müller W, Weichel W, Radbruch A (1990) High gradient magnetic cell separation with MACS. Cytometry 11:231
39. Minowada J, Ohnuma T, Moore GE (1972) Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst 49:891
40. Möller SA, Reisfeld RA (1991) Bispecific-monoclonal-antibody-directed lysis of ovarian carcinoma cells by activated human T lymphocytes. Cancer Immunol Immunother 33:210
41. Moutschen MP, Baudrihaye MF, Greimers R, Franchimant P, Boniver J (1990) Polyclonal T cell stimulation with an anti-CD3 monoclonal antibody generates cytotoxic effectors different from interleukin-2 activated killer cells. Int J Immunopathol Pharmacol 3:75
42. Muraguchi A, Kishimoto T, Miki Y, Kuritani T, Kaieda T, Yoshizaki K, Yamamura Y (1981) T cell-replacing factor-(TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF. J Immunol 127:412
43. Nakajima F, Khanna A, Xu G, Lagman M, Haschemeyer R, Mouradian J, Wang JC, Stenzel KH, Rubin AL, Suthanthiran M (1994) Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression. Proc Natl Acad Sci USA 91:7889
44. Nishimura T, Nakamura Y, Takeuchi Y, Tokuda Y, Iwasawa M, Kawasaki A, Okumura K, Habu S (1992) Generation, propagation, and targeting human CD4+ helper/killer T cells induced by anti-CD3 monoclonal antibody plus recombinant IL-2. An efficient strategy for adoptive tumor immunotherapy. J Immunol 148:285
45. Ochoa AC, Hasz DE, Rezonzew R, Anderson PM, Bach FH (1989) Lymphokine-activated killer activity in long-term cultures with anti-CD3 plus interleukin 2: identification and isolation of effector subsets. Cancer Res 49:963
46. Ortaldo JR, Mason A, Overton R (1986) Lymphokine-activated killer cells. Analysis of progenitors and effectors. J Exp Med 164:1193
47. Oshima S, Eckels DD (1990) Selective signal transduction through the CD3 or CD2 complex is required for Class II MHC expression by human T cells. J Immunol 145:4018
48. Parlevliet KJ, Chamuleau MED, Yong S-L, Raasveld MHM, Ten Berge IJM, Schellekens PTA (1995) Effects of anti-CD3 monoclonal antibodies on functional activity of lymphocytes: studies in vivo and in vitro. Clin Exp Immunol 99:155
49. Parmiani G (1990) An explanation of the variable clinical response to interleukin 2 and LAK cells. Immunol Today 11:113
50. Phillips JH, Lanier LL (1986) Dissection of the lymphokine-activated killer cell phenomenon. Relative contributions of pheripheral blood natural killer cells and T lymphocytes to cytolysis. J Exp Med 164:814
51. Pimentel-Muĩnos FX, Muñoz-Fernández MA, Fresno M (1994) Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines. J Immunol 152:5714
52. Qian J-H, Titus JA, Andrew SM, Mezzanzanica D, Garrido MA, Wunderlich JR, Segal DM (1991) Human peripheral blood lymphocytes targeted with bispecific antibodies release cytokines that are essential for inhibiting tumor growth. J Immunol 146:3150
53. Quinones RR, Segal DM, Henkart P, Perez P, Gress RE (1989) Inhibition of cytotoxic T cell lysis by anti-CD8 monoclonal antibodies: studies with CD3-targeted cytolysis of nominal antigen-negative targets. J Immunol 142:2200
54. Renner C, Jung W, Sahin U, Lier R van, Pfreundschuh M (1995) The role of lymphocyte subsets and adhesion molecules in T-cell-dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies. Eur J Immunol 25:2027
55. Rosenberg SA (1992) The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180
56. Rosenberg SA, Lotze MT, Mulé JJ (1988) New approaches to the immunotherapy of cancer using interleukin-2. Ann Int Med 108:853
57. Smyth MJ, Trapani JA (1995) Granzymes: exogenous proteinase that induce target cell apoptosis. Immunol Today 16:202
58. Suhrbier A, Fernan A, Burrows SR, Saul A, Moss DJ (1991) BLT esterase activity as an alternative to chromium release in cytotoxic T cell assays. J Immunol Methods 145:43
59. Sundström C, Nilsson K (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565
60. Svedersky LP, Shepard HM, Spencer SA, Shalaby MR, Palladino MA (1984) Augmentation of human natural cell-mediated cytotoxicity by recombinant human interleukin 2. J Immunol 133:714
61. Ting C-C, Hargrove ME, Wang J, Patel AD (1995) Differential requirement of protein tyrosine kinase and protein kinase C in the generation of IL-2-induced LAK cell and αCD3-induced CD3-AK cell responses. Cell Immunol 160:286
62. Weiss A, Wiskocil RL, Stobo JD (1984) The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL-2 production reflects events occuring at a pre-translational level. J Immunol 133:123
63. Xiao J, Brahmi Z (1989) Target cell-directed inactivation and IL-2 dependent reactivation of LAK cells. Cell Immunol 122:295
64. Yagita H, Nakata M, Azuma A, Nitta T, Takeshita T, Sugamura K. Okumura K (1989) Activation of peripheral blood T cells via the p75 interleukin 2 receptor. J Exp Med 170:1445
65. Zola H, Neoh SH, Mantzioris BX, Webster J, Loughnan MS (1990) Detection by immunofluorescence of surface molecules present in low copy numbers. High sensitivity staining and calibration of flow cytometer. J Immunol Methods 135:247