Simulation of the cellular oxygen effect with an SV40 DNA model system using DNA strand breaks as an end point

Radiation Research

Volumn 146, Issue 5, 1996, Pages 501-509

  Ayene, Iraimoudi S ^a   Koch, Cameron J ^a   Krisch, Robert E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; GLUTATHIONE; GLYCEROL; HYDROXYL RADICAL; OXYGEN; SCAVENGER; SINGLE STRANDED DNA; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; SIMIAN VIRUS 40; SIMULATION;

DNA DAMAGE; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLYCEROL; HYDROXYL RADICAL; OXYGEN; SIMIAN VIRUS 40;

DNA VIRUSES; LETHRINIDAE; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0029824858     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579550     Document Type: Article

References (32)

1. I. S. Ayene, C. J. Koch and R. E. Krisch, Modification of radiation-induced strand breaks by glutathione: Comparison of single- and double-strand breaks in SV40 DNA. Radiat. Res. 144, 1-8 (1995).
2. E. A. Bump and M. B. Brown, Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47, 117-136 (1990).
3. K. D. Held, H. A. Harrop and B. D. Michael, Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. Int. J. Radiat. Biol. 40, 613-622 (1981).
4. K. D. Held, H. A. Harrop and B. D. Michael, Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. III. Reaction rates. Int. J. Radiat. Biol. 45, 627-636 (1984).
5. K. D. Held and S. Awad, Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA. Int. J. Radiat. Biol. 59, 699-710 (1991).
6. S. Zheng, G. L. Newton, G. Gonick, R. C. Fahey and J. F. Ward, Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA. Radiat. Res. 114, 11-27 (1988).
7. S. Zheng, G. L. Newton, J. F. Ward and R. C. Fahey, Aerobic radio-protection of PBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat. Res. 130, 183-192 (1992).
8. C. Herskind and O. Westergaard, Variable protection by OH scavengers and radiation-induced inactivation of isolated transcriptionally active chromatin: The influence of secondary radicals. Radiat. Res. 114, 28-41 (1988).
9. J. R. Milligan and J. F. Ward, Yield of single-strand breaks due to attack on DNA by scavenger-derived radicals. Radiat. Res. 137, 295-299 (1994).
10. I. S. Ayene, C. J. Koch and R. E. Krisch, Role of scavenger-derived radicals in the induction of double-strand and single-strand breaks in irradiated DNA. Radiat. Res. 142, 133-143 (1995).
11. C. Herskind, Sulfhydryl protection and the oxygen effect on radiation-induced inactivation of r-chromatin in vitro. Radiat. Res. 115, 141-151 (1988).
12. P. C. Jocelyn, Biochemistry of the SH Groups, pp. 261-263. Academic Press, New York, 1972.
13. A. Meister and M. E. Anderson, Glutathione. Annu. Rev. Biochem. 52, 711-760 (1983).
14. R. Roots and S. Okada, Protection of DNA molecules of cultured mammalian cells from radiation-induced single strand scissions by various alcohols and SH compounds. Int. J. Radiat. Biol. 21, 329-342 (1972).
15. R. E. Krisch, M. B. Flick and C. N. Trumbore, Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA. Radiat. Res. 126, 251-259 (1991).
16. R. E. Krisch, I. S. Ayene and C. J. Koch, Interaction of thiols and non-thiol OH scavengers in the modification of radiation-induced DNA damage. In Radiation Damage in DNA: Structure/Function Relationships at Early Times (A. F. Fuciarelli and J. D. Zimbrick, Eds.), pp. 383-391. Battelle Press, Columbus, OH, 1995.
17. I. S. Ayene, A. B. Al-Mehdi and A. B. Fisher, Inhibition of lung tissue oxidation during ischemia/reperfusion by 2-mercaptopropionyl glycine. Arch. Biochem. Biophys. 303, 307-312 (1993).
18. R. C. Fahey, K. M. Prise, M. R. L. Stratford, R. R. Watfa and B. D. Michael, Rates for repair of pBR322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength. Int. J. Radiat. Biol. 59, 901-917 (1991).
19. W. A. Prutz and H. Monig, On the effect of oxygen or copper (II) in radiation-induced degradation of DNA in the presence of thiols. Int. J. Radiat. Biol. 52, 677-682 (1987).
20. C. J. Reed and K. T. Douglas, Chemical cleavage of plasmid DNA by glutathione in the presence of Cu(II) ions. Biochem. J. 275, 601-608 (1991).
21. •. Int. J. Radiat. Biol. 53, 767-786 (1988).
22. L. Grierson, K. Hildenbrand and E. Bothe, Intramolecular transformation reaction of the glutathione thiyl radical into a non-sulphurcentered radical: a pulse-radiolysis and EPR study. Int. J. Radiat. Biol. 62, 265-277 (1992).
23. T. R. Sweeney, A Survey of Compounds from the Drug Development Program of the U.S. Army Medical Research and Development Command. Walter Reed Army Institute of Research, Washington, DC, 1979.
24. J. A. Aguilera, G. L. Newton, R. C. Fahey and J. F. Ward, Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of net charge on the thiol. Radiat. Res. 130, 194-204 (1992).
25. L. H. Gray, A. D. Conger, M. Ebert, S. Hornsey and O. C. A. Scott, The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radial. 26, 638-648 (1953).
26. J. D. Chapman, D. L. Dugle, A. P. Reuvers, B. E. Meeker and J. Borsa, Studies on the radiosensitizing effect of oxygen in Chinese hamster cells. Int. J. Radiat. Biol. 26, 383-389 (1974).
27. E. A. Bump, N. Y. Yu and M. B. Brown, The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization. Int. J. Radiat. Oncol. Biol. Phys. 8, 439-442 (1982).
28. D. C, Shrieve, J. Denekamp and A. I. Minchinton, Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro. Radiat. Res. 102, 283-294 (1985).
29. M. R. Edgren, G. Solen and L. Revesz, Specificity of endogenous glutathione in determining the oxygen enhancement of cellular radiosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 12, 1147-1150 (1986).
30. J. D. Chapman, A. P. Reuvers, J. Borsa and C. L. Greenstock, Chemical radioprotection and radiosensitization of mammalian cells growing in vitro. Radiat. Res. 56, 291-306 (1973).
31. M. Liphard, E. Bothe and D. Schulte-Frohlinde, The influence of glutathione on single-strand breaks in single-stranded DNA irradiated in aqueous solution in absence and presence of oxygen. Int. J. Radiat. Biol. 58, 589-602 (1990).
32. B. D. Michael, Mechanisms of the oxygen effect in radiobiology. In Advances on Oxygen Radicals and Radioprotectors (A. Breccia, C. L. Greenstock and M. Tamba, Eds.), pp. 53-63. Lo Scarabeo, Bologna, 1984.