메뉴 건너뛰기




Volumn 52, Issue SUPPL. 2, 1996, Pages 18-26

Interleukin-12: Potential clinical applications in the treatment and prevention of infectious diseases

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CYTOKINE; GAMMA INTERFERON; GANCICLOVIR; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 12; STIBOGLUCONATE SODIUM;

EID: 0029824575     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199600522-00005     Document Type: Conference Paper
Times cited : (22)

References (49)
  • 1
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1944; 84: 4008-27
    • (1944) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 2
    • 0029188099 scopus 로고
    • Interleukin-12: Potential role in cancer therapy
    • DeVita Jr VT, Hellman S, Rosenberg SA, editors. Philadelphia: J.B. Lippincott
    • Brunda MJ, Gately MK. Interleukin-12: potential role in cancer therapy. In: DeVita Jr VT, Hellman S, Rosenberg SA, editors. Important advances in oncology 1995. Philadelphia: J.B. Lippincott, 1995: 3-18
    • (1995) Important Advances in Oncology 1995 , pp. 3-18
    • Brunda, M.J.1    Gately, M.K.2
  • 3
    • 0025808629 scopus 로고
    • Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor
    • Gubler U, Chua AO, Schoenhaut DS, et al. Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 1991; 88: 4143-7
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4143-4147
    • Gubler, U.1    Chua, A.O.2    Schoenhaut, D.S.3
  • 4
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • Wolf SF, Temple PA, Kobayashi M, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991; 146: 3074-81
    • (1991) J Immunol , vol.146 , pp. 3074-3081
    • Wolf, S.F.1    Temple, P.A.2    Kobayashi, M.3
  • 5
    • 0026693587 scopus 로고
    • Assignment of NKSF/IL 12, a unique cytokine composed of two unrelated subunits, to chromosomes 3 and 5
    • Sieburth D, Jabs EW, Warrington JA, et al. Assignment of NKSF/IL 12, a unique cytokine composed of two unrelated subunits, to chromosomes 3 and 5. Genomics 1992; 14: 59-62
    • (1992) Genomics , vol.14 , pp. 59-62
    • Sieburth, D.1    Jabs, E.W.2    Warrington, J.A.3
  • 6
    • 0027532502 scopus 로고
    • Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation
    • Naume B, Gately MK, Desai BB, et al. Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation. Cytokine 1993; 5: 38-46
    • (1993) Cytokine , vol.5 , pp. 38-46
    • Naume, B.1    Gately, M.K.2    Desai, B.B.3
  • 7
    • 0026605457 scopus 로고
    • IL-12 receptor. II. Distribution and regulation of recepTor expression
    • Desai BB, Quinn PM, Wolitzky AG, et al. IL-12 receptor. II. Distribution and regulation oF recepTor expression. J Immunol 1992; 148: 3125-32
    • (1992) J Immunol , vol.148 , pp. 3125-3132
    • Desai, B.B.1    Quinn, P.M.2    Wolitzky, A.G.3
  • 8
    • 0028235663 scopus 로고
    • Expression cloning of a human IL-12 receptor component: A new member of the cytokine receptor superfamily with strong homology to gp130
    • Chua AO, Chizzonite R, Desai BB, et al. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994; 153: 128-36
    • (1994) J Immunol , vol.153 , pp. 128-136
    • Chua, A.O.1    Chizzonite, R.2    Desai, B.B.3
  • 10
    • 0027177008 scopus 로고
    • IL-12: Initiation cytokine for cell-mediated immunity
    • Scott P. IL-12: initiation cytokine for cell-mediated immunity. Science 1993; 260: 496-7
    • (1993) Science , vol.260 , pp. 496-497
    • Scott, P.1
  • 11
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti R, Parronchi P, Giudizi MG, et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177: 1199-204
    • (1993) J Exp Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3
  • 12
    • 0027336689 scopus 로고
    • H1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • H1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993; 260: 547-9
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.-S.1    Macatonia, S.E.2    Tripp, C.S.3
  • 13
    • 0028230984 scopus 로고
    • B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation
    • Murphy EE, Terres G, Macatonia SE, et al. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 1994; 180: 223-31
    • (1994) J Exp Med , vol.180 , pp. 223-231
    • Murphy, E.E.1    Terres, G.2    Macatonia, S.E.3
  • 14
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
    • Kobayashi M, Fitz L, Ryan M, et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 1989; 170: 827-45
    • (1989) J Exp Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3
  • 15
    • 0025819340 scopus 로고
    • Induction of interferon γ production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
    • Chan SH, Perussia B, Gupta JW, et al. Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 1991; 173: 869-79
    • (1991) J Exp Med , vol.173 , pp. 869-879
    • Chan, S.H.1    Perussia, B.2    Gupta, J.W.3
  • 16
    • 0027264849 scopus 로고
    • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts
    • Gazzinelli RT, Heiny S, Wynn TA, et al. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993; 90: 6115-9
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Heiny, S.2    Wynn, T.A.3
  • 17
    • 0027528795 scopus 로고
    • Recombinant interleukin 12 cures mice infected with Leishmania major
    • Heinzel FP, Schoenhaut DS, Rerko RM, et al. Recombinant interleukin 12 cures mice infected with Leishmania major: J Exp Med 1993; 177: 1505-9
    • (1993) J Exp Med , vol.177 , pp. 1505-1509
    • Heinzel, F.P.1    Schoenhaut, D.S.2    Rerko, R.M.3
  • 18
    • 0028071922 scopus 로고
    • In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS)
    • Gazzinelli RT, Giese NA, Morse III HC. In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J Exp Med 1994; 180: 2199-208
    • (1994) J Exp Med , vol.180 , pp. 2199-2208
    • Gazzinelli, R.T.1    Giese, N.A.2    Morse III, H.C.3
  • 19
    • 0026691714 scopus 로고
    • Regulation of human cytolytic lymphocyte responses by interleukin-12
    • Gately MK, Wolitzky AG, Quinn PM, et al. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 1992; 143: 127-42
    • (1992) Cell Immunol , vol.143 , pp. 127-142
    • Gately, M.K.1    Wolitzky, A.G.2    Quinn, P.M.3
  • 20
    • 0028096083 scopus 로고
    • Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
    • Gately MK, Warrier RR, Honasoge S, et al. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int Immunol 1994; 6: 157-67
    • (1994) Int Immunol , vol.6 , pp. 157-167
    • Gately, M.K.1    Warrier, R.R.2    Honasoge, S.3
  • 21
    • 0027226015 scopus 로고
    • Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes
    • Mehrotra PT, Wu D, Crim JA, et al. Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes. J Immunol 1993; 151: 2444-52
    • (1993) J Immunol , vol.151 , pp. 2444-2452
    • Mehrotra, P.T.1    Wu, D.2    Crim, J.A.3
  • 22
    • 0025873502 scopus 로고
    • Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
    • Gately MK, Desai BB, Wolitzky AG, et al. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 1991; 147: 874-82
    • (1991) J Immunol , vol.147 , pp. 874-882
    • Gately, M.K.1    Desai, B.B.2    Wolitzky, A.G.3
  • 23
    • 0028836185 scopus 로고
    • Role of IL-12 in human B lymphocyte proliferation and differentiation
    • Jelinek DF, Braaten JK, Role of IL-12 in human B lymphocyte proliferation and differentiation. J Immunol 1995; 154: 1606-13
    • (1995) J Immunol , vol.154 , pp. 1606-1613
    • Jelinek, D.F.1    Braaten, J.K.2
  • 24
    • 0028926776 scopus 로고
    • Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo
    • Germann T, Bongartz M, Dlugonska H, et al. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur J Immunol 1995; 25: 823-9
    • (1995) Eur J Immunol , vol.25 , pp. 823-829
    • Germann, T.1    Bongartz, M.2    Dlugonska, H.3
  • 25
    • 0027309318 scopus 로고
    • Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response
    • Sypek JP, Chung CL, Mayor SEH, et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 1993; 177: 1797-802
    • (1993) J Exp Med , vol.177 , pp. 1797-1802
    • Sypek, J.P.1    Chung, C.L.2    Mayor, S.E.H.3
  • 26
    • 0028934155 scopus 로고
    • Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pcntostam
    • Nabors GS, Afonso LCC, Farrell JP, et al. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pcntostam. Proc Natl Acad Sci USA 1995; 92: 3142-6
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3142-3146
    • Nabors, G.S.1    Afonso, L.C.C.2    Farrell, J.P.3
  • 27
    • 0028049247 scopus 로고
    • The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
    • Afonso LCC, Scharton TM, Vieira LQ, et al. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994; 263: 235-7
    • (1994) Science , vol.263 , pp. 235-237
    • Afonso, L.C.C.1    Scharton, T.M.2    Vieira, L.Q.3
  • 28
    • 0027939611 scopus 로고
    • Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
    • Gazzinelli R, Wysocka M, Hayashi S, et al. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994; 153: 2533-43
    • (1994) J Immunol , vol.153 , pp. 2533-2543
    • Gazzinelli, R.1    Wysocka, M.2    Hayashi, S.3
  • 29
    • 0028947010 scopus 로고
    • The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection
    • Cooper AM, Roberts AD, Rhoades ER, et al. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 1995; 84: 423-32
    • (1995) Immunology , vol.84 , pp. 423-432
    • Cooper, A.M.1    Roberts, A.D.2    Rhoades, E.R.3
  • 30
    • 0029079391 scopus 로고
    • IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ
    • Zhou P, Sieve MC, Bennett J, et al. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J Immunol 1995; 155: 785-95
    • (1995) J Immunol , vol.155 , pp. 785-795
    • Zhou, P.1    Sieve, M.C.2    Bennett, J.3
  • 31
    • 0028062795 scopus 로고
    • IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis
    • Romani L, Mencacci A, Tonnetti L, et al. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J Immunol 1994; 153: 5167-75
    • (1994) J Immunol , vol.153 , pp. 5167-5175
    • Romani, L.1    Mencacci, A.2    Tonnetti, L.3
  • 32
    • 0028220266 scopus 로고
    • Interleukin 12 at the site of disease in tuberculosis
    • Zhang M, Gately MK, Wang E, et al. Interleukin 12 at the site of disease in tuberculosis. J Clin Invest 1994; 93: 1733-9
    • (1994) J Clin Invest , vol.93 , pp. 1733-1739
    • Zhang, M.1    Gately, M.K.2    Wang, E.3
  • 33
    • 0028266819 scopus 로고
    • Effects of IL-12 on the response and susceptibility to experimental vital infections
    • Orange JS, Wolf SF, Biron CA. Effects of IL-12 on the response and susceptibility to experimental vital infections. J Immunol 1994; 152: 1253-64
    • (1994) J Immunol , vol.152 , pp. 1253-1264
    • Orange, J.S.1    Wolf, S.F.2    Biron, C.A.3
  • 34
    • 0028957492 scopus 로고
    • Mechanism of interleukin 12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoids
    • Orange JS, Salazar-Mather TP, Opal SM, et al. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J Exp Med 1995; 181: 901-14
    • (1995) J Exp Med , vol.181 , pp. 901-914
    • Orange, J.S.1    Salazar-Mather, T.P.2    Opal, S.M.3
  • 35
    • 0028878655 scopus 로고
    • Interleukin-12 gene expression after viral infection in the mouse
    • Coutelier J-P, van Broeck J, Wolf SF. Interleukin-12 gene expression after viral infection in the mouse. J Virol 1995; 69: 1955-8
    • (1995) J Virol , vol.69 , pp. 1955-1958
    • Coutelier, J.-P.1    Van Broeck, J.2    Wolf, S.F.3
  • 36
    • 43949158538 scopus 로고
    • The Th1-Th2 hypothesis of HIV infection: New insights
    • Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today 1994; 15: 575-81
    • (1994) Immunol Today , vol.15 , pp. 575-581
    • Clerici, M.1    Shearer, G.M.2
  • 37
    • 0028262475 scopus 로고
    • Impaired interleukin 12 production in human immunodeficiency virus-infected patients
    • Chehimi J, Starr SE, Frank I, et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994; 179: 1361-6
    • (1994) J Exp Med , vol.179 , pp. 1361-1366
    • Chehimi, J.1    Starr, S.E.2    Frank, I.3
  • 38
    • 0026591094 scopus 로고
    • Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients
    • Chehimi J, Starr SE, Frank I, et al. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J Exp Med 1992; 175: 789-96
    • (1992) J Exp Med , vol.175 , pp. 789-796
    • Chehimi, J.1    Starr, S.E.2    Frank, I.3
  • 39
    • 0027743305 scopus 로고
    • Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro
    • Clerici M, Lucey DR, Berzofsky JA, et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993; 262: 1721-4
    • (1993) Science , vol.262 , pp. 1721-1724
    • Clerici, M.1    Lucey, D.R.2    Berzofsky, J.A.3
  • 40
    • 0028032846 scopus 로고
    • Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis
    • Clerici M, Sarin A, Coffman RL, et al. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 1994; 91: 11811-5
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11811-11815
    • Clerici, M.1    Sarin, A.2    Coffman, R.L.3
  • 41
    • 0028985743 scopus 로고
    • 2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication
    • 2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. Blood 1995; 85: 2114-23
    • (1995) Blood , vol.85 , pp. 2114-2123
    • Foli, A.1    Saville, M.W.2    Baseler, M.W.3
  • 42
    • 0027969127 scopus 로고
    • Interleukin-12: A cytokine with therapeutic potential in oncology and infectious diseases
    • Gately MK, Gubler U, Brunda MJ, et al. Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases. Therapeutic Immunol 1994; 1: 187-96
    • (1994) Therapeutic Immunol , vol.1 , pp. 187-196
    • Gately, M.K.1    Gubler, U.2    Brunda, M.J.3
  • 43
    • 0028036778 scopus 로고
    • Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates
    • Bree AG, Schlerman FJ, Kaviani MD, et al. Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates. Biochem Biophys Res Comm 1994; 204: 1150-7
    • (1994) Biochem Biophys Res Comm , vol.204 , pp. 1150-1157
    • Bree, A.G.1    Schlerman, F.J.2    Kaviani, M.D.3
  • 44
    • 0028603492 scopus 로고
    • Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Saimiri sciureus)
    • Sarmiento UM, Riley JH, Knaack PA, et al. Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Saimiri sciureus). Lab Invest 1994; 71: 862-73
    • (1994) Lab Invest , vol.71 , pp. 862-873
    • Sarmiento, U.M.1    Riley, J.H.2    Knaack, P.A.3
  • 45
    • 0028926524 scopus 로고
    • Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
    • Trembleau S, Penna G, Bosi E, et al. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 1995; 181: 817-21
    • (1995) J Exp Med , vol.181 , pp. 817-821
    • Trembleau, S.1    Penna, G.2    Bosi, E.3
  • 46
    • 0029034038 scopus 로고
    • Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice
    • Germann T, Szeliga J, Hess H, et al. Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci USA 1995; 92: 4823-7
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4823-4827
    • Germann, T.1    Szeliga, J.2    Hess, H.3
  • 47
    • 0027982098 scopus 로고
    • Interleukin 12, interferon γ, and tumor necrosis factor a are the key cytokines of the generalized Shwartzman reaction
    • Ozmen L, Pericin M, Hakimi J, et al. Interleukin 12, interferon γ, and tumor necrosis factor a are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994; 180: 907-15
    • (1994) J Exp Med , vol.180 , pp. 907-915
    • Ozmen, L.1    Pericin, M.2    Hakimi, J.3
  • 48
    • 0028987562 scopus 로고
    • Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
    • Wysocka M, Kubin M, Vieira LQ, et al. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol 1995; 25: 672-6
    • (1995) Eur J Immunol , vol.25 , pp. 672-676
    • Wysocka, M.1    Kubin, M.2    Vieira, L.Q.3
  • 49
    • 0029056166 scopus 로고
    • Pharmacokinetics and pharmacodynamics of recombinant human interleukin-12 in male rhesus monkeys
    • Nadeau RR, Ostrowski C, Ni-Wu G, et al. Pharmacokinetics and pharmacodynamics of recombinant human interleukin-12 in male rhesus monkeys. J Pharmacol ExpTher 1995; 274: 78-83
    • (1995) J Pharmacol ExpTher , vol.274 , pp. 78-83
    • Nadeau, R.R.1    Ostrowski, C.2    Ni-Wu, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.