Heterogeneous expression of carcinoembryonic antigen in the normal colon and upregulation in active ulcerative colitis

Journal of Pathology

Volumn 180, Issue 2, 1996, Pages 146-151

  Smithson, John E ^a   Warren, Bryan F ^b   Young, Susan ^c   Pigott, Rod ^d   Jewell, Derek P ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c Applied Development Laboratory   (United Kingdom)

^d Neures Ltd   (United Kingdom)

Author keywords

carcinoembryonic antigen; colonic mucosa; immunohistochemistry; tolerization; ulcerative colitis

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; IMMUNOGLOBULIN G1;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADULT; AGED; ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOEMBRYONIC ANTIGEN; COLITIS, ULCERATIVE; COLON; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; RECTUM;

EID: 0029824519     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199610)180:2<146::AID-PATH643>3.0.CO;2-E     Document Type: Article

References (30)

1. Both H, Torp-Pedersen K, Kreiner S, Hendriksen C, Binder V. Clinical appearances at diagnosis of ulcerative colitis and Crohn's disease in a regional patient group. Stand J Gastroenterol 1983; 18: 987-991.
2. Nordenvall B, Brostrom O, Berglund M, et al. Incidence of ulcerative colitis in Stockholm County 1955-1979. Stand J Gastroenterol 1985; 20: 783-790.
3. Sinclair TS, Brunt PW, Mowat NAG. Nonspecific proctocolitis in north-eastern Scotland: a community study. Gastroenterology 1983; 85: 1-11.
4. Halstensen TS, Das KM, Brandtzaeg P. Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40 kD putative autoantigen in ulcerative colitis. Gut 1993; 34: 650-657.
5. Chapman MAS, Grahn MF, Boyle MA, Hutton M, Rogers J, Williams NS. Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut 1994; 35: 73-76.
6. Roediger WEW. The colonic epithelium in ulcerative colitis: an energy deficiency disease? Lancet 1980; ii: 712-715.
7. Roediger WEW. Role of anerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980; 21: 793-798.
8. Rhodes JM. Colonic mucus and mucosal glycoproteins: the key to colitis and cancer? Gut 1989; 30: 1660-1666.
9. Matthew WD, Sandrock AW. Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies. J Immunol Methods 1987; 100: 73-82.
10. Smithson JE, Prince C, Pigott R, Jewell DP. Production of monoclonal antibodies with site-specific reactivity in human colonic mucosa. Clin Sci 1994; 86: 11p.
11. Smithson JE, Bloom S, Campbell A, Prince C, Pigott R, Jewell DP. A novel monoclonal antibody reveals enhanced expression of secretory component in proximal compared to distal colon. Gastroenterology 1994; 106: A776.
12. Smithson JE, Campbell A, Andrews J, Prince C, Pigott R, Jewell DP. Mucin abnormalities in ulcerative colitis revealed by novel monoclonal antibodies. Gastroenterology 1994; 106: A776.
13. Smithson JE, Warren BF, Young S, Pigott R, Jewell DP. Increased expression of carcinoembryonic antigen (CEA) in the normal proximal colon and upregulation in active ulcerative colitis. Gastroenterology 1994; 108: A919.
14. Durbin H, Young S, Stewart LM, et al. An epitope on carcinoembryonic antigen defined by the clinically relevant antibody PR1A3. Proc Natl Acad Sci USA 1994; 91: 4313-4317.
15. Richman PI, Bodmer WF. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization. Int J Cancer 1987; 39: 317-328.
16. Gold P, Freedman S. Demonstration of tumor-specific antigens in human colon carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439-462.
17. Kuikpers TW, Hoogerwerf M, van der Laan LJ, et al. CD66 nonspecific cross-reacting antigens are involved in adherence to cytokine-activated endothelial cells. J Cell Biol 1992; 118: 457-466.
18. Pignatelli M, Durbin H, Bodmer WF. Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc Natl Acad Sci USA 1990; 87: 1541-1545.
19. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 1989; 57: 327-334.
20. Ahnen DJH, Nakane PK. Ultrastructural localization of carcinoembryonic antigen in normal intestine and colorectal cancer; abnormal distribution of CEA on the surfaces of colon cancer cells. Cancer 1982; 49: 2077-2090.
21. Abrasi AM, Chester KA, Macpherson AJS, Boxer GM, Begent RH, Malcolm ADB. Localization of CEA messenger RNA by in situ hybridization in normal colonic mucosa and colorectal adenocarcinomas. J Pathol 1992; 168: 405-411.
22. Leusch HG, Hefta SA, Drzeniek Z, Hummel K, Markos PZ, Wagener C. Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA). FEBS Lett 1990; 261: 405-409.
23. Thomas P, Toth CA, Saini KS, Jessup M, Steele G. The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim Biophys Acta 1990; 1032: 177-189.
24. Saini K, Steele G, Thomas P. Induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate. Biochem J 1990; 272: 541-544.
25. Toth CA, Thomas P. The effect of Interferon treatment on 14 human colorectal cancer cell lines: growth and carcinoembryonic antigen secretion in vitro. J. Interferon Res 1990; 10: 579-588.
26. Rognum TO, Elgjo K, Fausa O, Brandtzeg P. Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in ulcerative colitis with dysplasia. Gut 1982; 23: 123-133.
27. Campbell AP, Merrett MN, Kettlewell M, Mortensen NJ, Jewell DP. Expression of colonic antigens by goblet and columnar epithelial cells in ileal pouch mucosa: their association with inflammatory change and faecal stasis. J Clin Pathol 1994; 47: 834-838.
28. Chapman RW, Selby WS, Jewell DP. Controlled trial of intravenous metronidazole as an adjunct to coticosteroids in severe ulcerative colitis. Gut 1986; 27: 1210-1212.
29. Mantzaris GJ, Hatzis A, Kontogiannis P, Trìadaphyllou G. Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis. Am J Gastroenterol 1994; 89: 43-46.
30. Burke DA, Axon AT, Clayden SA, Dixon MF. The efficacy of tobramycin in the treatment of ulcerative colitis. Aliment Pharm Ther 1990; 4: 123-129.