Comparative impact of cephaloridine on glutathione and related enzymes in LLC-PK1, LLC-RK1, and primary cultures of rat and rabbit proximal tubule cells

Cell Biology and Toxicology

Volumn 12, Issue 4-6, 1996, Pages 275-282

  Morin, J P ^a,b   Marouillat, S ^a   Lendormi, C ^a   Monteil, C ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b INSERM   (France)

Author keywords

cephaloridine; glutathione metabolism; nephrotoxicity; phenotype comparison; proximal tubule; renal cell culture

Indexed keywords

CEFALORIDINE; GLUTATHIONE;

ANIMAL CELL; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; GLUTATHIONE METABOLISM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NEPHROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RABBIT; SWINE;

ANIMALS; CELLS, CULTURED; CEPHALORIDINE; ENZYMES; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; KIDNEY TUBULES, PROXIMAL; LLC-PK1 CELLS; RABBITS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; SWINE;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0029824050     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00438158     Document Type: Conference Paper

References (15)

1. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein, utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248-54.
2. Courjault F, Leroy D, Coquery I, Toutain H. Platinum complex-induced dysfunctions for cultured renal proximal tubule cells. A comparative study of carboplatin and transplatin with cisplatin. Arch Toxicol. 1993;67:338-46.
3. Genestie I, Morin JP, Vannier B, Lorenzon G. Polarity and transport properties of rabbit kidney proximal tubule cells on collagen-IV coated porous membranes. Am J Physiol. 1995;269:F22-30.
4. Hjelle JT, Morin JP, Trouet A. Analytical cell fractionation of isolated rabbit renal proximal tubules. Kidney Int. 1981;20: 71-7.
5. Hull RN, Dwyer AC, Cherry WR, Triebt OJ. Development and characterization of the rabbit kidney cell strain LLC-RK1. Proc Soc Exp Biol Med. 1965;118:1045-59.
6. Hull RN, Cherry WR, Weaver GW. The origin and characteristics of a pig kidney cell strain, LLC-PK1. In Vitro. 1976;12:670-7.
7. Monteil C, Leclere C, Dantzer F, Eklaz V, Fillastre JP, Morin JP. Modulation of glycolysis induction in primary cultures of rabbit kidney proximal tubule cells: the role of shaking, glucose and insulin. Cell Biol Int Rep. 1993a;17:953-60.
8. Monteil C, Leclere C, Fillastre JP, Morin JP. Characterization of gentamicin induced dysfunctions in vitro: the use of optimized primary cultures of rabbit proximal tubule cells. Renal Failure. 1993b;15:475-83.
9. Morin JP, Monteil C, Glomot R, Fillastre JP. Rabbit kidney proximal tubule cells in primary culture: evaluation of the impact of expressed phenotype on cellular toxic response. Toxicol In Vitro. 1991;5:383-8.
10. Morin JP, Leclere C, Marouillat S, Monteil C. Some milestones in in vitro organ toxicity assessment. The kidney as a case study. Toxicol In Vitro. 1995;9:795-814.
11. Moritz F, Marouillat S, Monteil C et al. Impact of cephaloridine on glutathione and related enzymes: comparison of in vivo and in vitro rat models. Arch Toxicol. 1995;70:104-11.
12. Rush GF, Heim RA, Ponsier GD, Engelhardt J. Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension. Toxicol Pathol. 1992;2:155-67.
13. Toutain H, Morin JP. Renal proximal tubule cell cultures for studying drug-induced nephrotoxicity and modulation of phenotype expression by medium components. Renal Failure. 1992;14:371-83.
14. Williams PD, Laska DA, Tay LK, Hottendorf GH. Comparative toxicities of cephalosporin antibiotics in a rabbit kidney cell line (LLC-RK1). Antimicrob Agents Chemother. 1988; 32:314-8.
15. Williams PD, Buening MK, Gries CL et al. Comparative toxicity of oral cephalosporin antibiotics in the rabbit and in a rabbit kidney cell line (LLC-RK1). Toxicol In Vitro. 1990;4:207-10.