Effervescent and standard formulations of ranitidine - A comparison of their pharmacokinetics and pharmacology

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 6, 1996, Pages 913-918

  Watson, R G P ^a   Johnston, B T ^a   Tham, T C K ^a   Kersey, K ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RANITIDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PH; TABLET;

EID: 0029823369     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1996.69240000.x     Document Type: Article

References (6)

1. Strom M, Madsen S, Norlander B. Intragastric pH rise with effervescentcitrate-cimetidine.Lancet 1991; 337(8738): 433.
2. Vlasblom V. Fellinger HW, Breumelhof R, Smout AJPM. Effects of a new effervescent cimetidine formulation on gastric acidity in healthy subjects. Neth J Med 1991; 38: 147-52.
3. 2 receptor-antagonists be taken in an effervescent formulation ? Eur J Gastroenterol Hepatol 1991; 3(Suppl. 1): 538 (Abstract 151).
4. Devis G, De Rop H, Du Cille L, et al. Rapid absorption and high plasma concentrations with the ranitidine effervescent formulation results in a very quick onset of action on the intragastric pH in volunteers. Scand J Gastroenterol 1993; 28 (Suppl. 197): 70 (Abstract 13).
5. Metropolitan Life Insurance Tables. 1979 Build Study, Society of Actuaries and Association of Life Insurance Directors of America. Metropolitan Life Insurance Company, 1983.
6. Smout AJPM, Jonkman JHG, Peeters PA, De Bruin H. Effect of an evening dose of regular and effervescent formulations of ranitidine or cimetidine on intragastric pH in healthy volunteers. Aliment Pharmacol Ther 1995; 9: 51-6.