Incorporation of nuclear matrix attachment regions into the herpes simplex virus type 1 genome does not induce long-term expression of a foreign gene during latency

Gene Therapy

Volumn 3, Issue 9, 1996, Pages 829-833

  Makarova, O ^a   Gorneva, G ^a   Wu, F ^a   Farutin, V ^a   Villeponteau, B ^a,b   Poliani, L ^a,c   Fink, D ^a,c   Levine, M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b GERON CORPORATION   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

HSV 1 latency; Long term expression; Matrix attachment regions

Indexed keywords

BETA GALACTOSIDASE; BETA GLOBIN; LYSOZYME; RECOMBINANT DNA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS MATRIX; CONTROLLED STUDY; CORPUS STRIATUM; DNA FLANKING REGION; DNA SEQUENCE; ENZYME ACTIVITY; GENE INDUCTION; GENE REPRESSION; GLOBIN GENE; HERPES SIMPLEX VIRUS 1; HIPPOCAMPUS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; VIRUS GENOME; VIRUS LATENCY; VIRUS RECOMBINANT;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; CHICKENS; DNA, RECOMBINANT; GENE EXPRESSION REGULATION, VIRAL; GENES; GENES, REPORTER; GLOBINS; HERPESVIRUS 1, HUMAN; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MALE; MURAMIDASE; NUCLEAR MATRIX; RATS; RATS, SPRAGUE-DAWLEY; VIRUS LATENCY;

ANIMALIA; DNA VIRUSES; GALLUS GALLUS; HERPES; HUMAN HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS; MUS MUSCULUS;

EID: 0029822920     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Roizman B, Sears AE. An inquiry into the mechanisms of herpes simplex virus latency. Annu Rev Microbiol 1987; 41: 543-571.
2. Stevens JG. Human herpesviruses: a consideration of the latent state. Microbiol Rev 1989; 53: 318-332.
3. Fraser NW, Block TM, Spivack JG. The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology 1992; 191: 1-8.
4. Stevens JG, Cook ML. Latent herpes simplex virus in spinal ganglia of mice. Science 1971; 173: 843-845.
5. Rock DL, Fraser NW. Detection of HSV-1 genome in central nervous system of latently infected mice. Nature 1983; 302: 523-525.
6. Efstathiou S et al. Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans. J Virol 1986; 57: 446-455.
7. Mellerick DM, Fraser NW. Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology 1987; 158: 265-275.
8. Deshmane SL, Fraser NW. During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J Virol 1989; 63: 943-947.
9. Hill TJ. Herpes simplex virus latency. In: Boizman B (ed). Herpes Viruses. Plenum Press: New York, 1985, pp 175-240.
10. Ramakrishnan R et al. Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol 1994; 68: 1864-1873.
11. Ramakrishnan R, Levine M, Fink DJ. PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol 1994; 68: 7083-7091.
12. Fink DJ et al. In vivo expression of beta-galactosidase in hippocampal neurons by HSV-mediated gene transfer. Hum Gene Ther 1992; 3: 11-19.
13. Han M, Grunstein MA. Nucleosomes loss activates yeast downstream promoters in vivo. Cell 1988; 55: 1137-1145.
14. Piña B, Bruggemeia U, Beato M. Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell 1990; 60: 719-731.
15. Archer TC, Cordingley MG, Wolford RG, Haga GL. Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter. Mol Cell Biol 1991; 11: 688-698.
16. Nelson WG, Pienta KJ, Barrack ER, Coffey DS. The role of the nuclear matrix in the organization and function of DNA. Annu Rev Biophys Chem 1986; 15: 457-475.
17. Bodnar JW. A domain model for eukaryotic DNA organization: a molecular basis for cell differentiation and chromosome evolution. J Theor Biol 1988; 132: 479-507.
18. Laemmli UK, Kas E, Poljak L, Adachi Y. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr Opin Genet Dev 1992; 2: 275-285.
19. He DC, Nickerson JA, Penman S. Core filaments of the nuclear matrix. J Cell Biol 1990; 110: 569-580.
20. Fey EG, Bangs P, Sparks C, Odgren P. The nuclear matrix: defining structural and functional roles. Crit Rev Eukaryot Gene Expr 1991; 1: 127-143.
21. Cook PR. The nucleoskeleton and the topology of replication. Cell 1991; 66: 627-635.
22. Gasser S. Replication origins factors and attachment sites. Curr Opin Cell Biol 1991; 3: 407-413.
23. Zeitlin S, Parent A, Silverstein S, Efstratiadis A. Pre-mRNA splicing and the nuclear matrix. Mol Cell Biol 1987; 7: 111-120.
24. Zeitlin S, Wilson RC, Efstratiadis A. Autonomous splicing and complementation of in vivo-assembled spliceosomes. J Cell Biol 1989; 108: 765-777.
25. Huang S, Spector DL. Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes Dev 1991; 5: 2288-2302.
26. Carter KC et al. A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science 1993; 259: 1330-1335.
27. Xing Y, Johnson CV, Dobner PR, Lawrence JB. Higher level organization of individual gene transcription and RNA splicing. Science 1993; 259: 1326-1330.
28. Getzenberg RH. Nuclear matrix and the regulation of gene expression: tissue specificity. J Cell Biochem 1994; 55: 22-31.
29. Cockerill PN, Garrard WT. Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 1986; 44: 273-282.
30. Phi-Van L, Strätling WH. The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain. EMBO J 1988; 7: 655-664.
31. Stief A, Winter DM, Stratling WH, Sippel AE. A nuclear DNA attachment element mediates elevated and position-independent gene activity. Nature 1989; 341: 343-345.
32. Phi-Van L, Kries JPV, Ostertag W, Strätling WH. The chicken lysozyme 5′ matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol Cell Biol 1990; 10: 2302-2307.
33. McKnight RA et al. Matrix attachment regions can impart position-independent regulation of a tissue specific gene in transgenic mice. Proc Natl Acad Sci USA 1992; 89: 6943-6947.
34. Bonifer C, Vidal M, Grosveld F, Sippel AE. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J 1990; 9: 2843-2848.
35. Kalos M, Faurnier REK. Position-independent transgene expression mediated by boundary elements from the apolipo-protein B chromatin domain. Mol Cell Biol 1995; 15: 198-207.
36. Cheng JH, Whitdey M, Felsenfeld G. The 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 1993; 74: 505-514.
37. Cai H, Levine M. Modulation of enhancer-promoter interactions by insulators in Drosophila embryo. Nature 1995; 376: 533-536.
38. Jankelevich S, Kolman JL, Bodnar JW, Miller G. A nuclear matrix attachment region organizes the Epstein-Barr viral plasmid in Raji cells into a single DNA domain. EMBO J 1992; 11: 1165-1176.
39. Yu J, Bock JH, Slightom JL, Villeponteau B. A 5′ beta-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription. Gene 1994; 139: 139-145.
40. Schubert D et al. Clonal cell lines from the rat central nervous system. Nature 1974; 249: 224-227.
41. Sauer B, Whealy A, Robins A, Enquist L. Site-specific insertion of DNA into a pseudorabies vector. Proc Natl Acad Sci USA 1987; 84: 9108-9112.
42. Forss-Petter S et al. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990; 5: 187-197.
43. Corboy JR, Buzy JM, Zink MC, Clements JE. Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 1992; 258: 1804-1808
44. Meignier B et al. Virulence of and establishment of latency genetically engineered deletion mutants of herpes simplex virus 1. Virology 1988; 162: 251-254.
45. Longnecker R, Roizman B. Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome. Science 1987; 237: 573-576.