Regulation of RARβ2 mRNA expression: Evidence for an inhibitory peptide encoded in the 5'-untranslated region

Journal of Cell Biology

Volumn 134, Issue 4, 1996, Pages 827-835

  Reynolds, Kay ^a   Zimmer, Anne M ^a   Zimmer, Andreas ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; MESSENGER RNA; POLYPEPTIDE; RECEPTOR SUBTYPE; RETINOIC ACID RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE MUTATION; MOUSE; NONHUMAN; OPEN READING FRAME; POINT MUTATION; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRANSLATION REGULATION;

ANIMALIA; MUS MUSCULUS;

EID: 0029822293     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.134.4.827     Document Type: Article

References (45)

1. Abastado, J.P., P.F. Miller, and A.G. Hinnebusch. 1991. A quantitative model for translational control of the GCN4 gene of Saccharomyces cerevisiae. New Biol. 3:511-524.
2. Arrick, B.A., A.L. Lee, R.L. Grendell, and R. Derynick. 1991. Inhibition of translation of transforming growth factor-β 3 mRNA by its 5′ untranslated region. Mol. Cell. Biol. 11:4306-4313.
3. Atwater, J.A., R. Wisdom, and I.M. Verma. 1990. Regulated mRNA stability. Annu. Rev. Genet. 24:519-541.
4. Degnin, C.R., M.R. Schleiss, J. Cao, and A.P. Geballe. 1993. Translational inhibition mediated by a short upstream open reading frame in the human cytomegalovirus gpUL4 (gp48) transcript. J. Virol. 67:5514-5521.
5. Donzé, O., and P.-F. Spahr. 1992. Role of the open reading frames of Rous sarcoma virus leader RNA in translation and genome packaging. EMBO (Eur. Mol. Biol. Organ.) J. 11:3747-3757.
6. Dyson, E., H.M. Sucov, S.W. Kubalak, G.W. Schmid-Schönbein, F.A. DeLano, R.M. Evans, J.J. Ross, and K.R. Chien. 1995. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor a -/- mice. Proc. Natl. Acad. Sci. USA 92:7386-7390.
7. Eisel, U., K. Reynolds, M. Riddick, A. Zimmer, H. Niemann, and A. Zimmer. 1993. Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis. EMBO (Eur. Mol. Biol. Organ.) J. 12:3365-3372.
8. Evans, R.M. 1988. The steroid and thyroid hormone receptor superfamily. Science (Wash. DC). 240:889-895.
9. GeBalle, A.P., and D.R. Morris. 1994. Initiation codons within 5′-leaders of mRNAs as regulators of translation. Trends Biochem. Sci. 19:159-164.
10. Grant, C.M., P.F. Miller, and A.G. Hinnebusch. 1994. Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron. Mol. Cell. Biol. 14:2616-2628.
11. Hart, R.C., K.J. Winn, and E.R. Unger. 1992. Avian model for 13-cis-retinoic acid embryopathy: morphological characterization of ventricular septal defects. Teratology. 46:533-539.
12. Hill, J.R., and D.R. Morris. 1992. Cell-specific translation of S-adenosylmethionine decarboxylase mRNA. Regulation by the 5′ transcript leader. J. Biol. Chem. 267:21886-21893.
13. Hill, J.R., and D.R. Morris. 1993. Cell-specific transational regulation of S-adenosylmethionine decarboxylase mRNA. Dependence on translation and coding capacity of the cis-acting upstream open reading frame. J. Biol. Chem. 268:726-731.
14. Kastner, P., J.M. Grondona, M. Mark, A. Gansmuller, M. LeMeur, d. Decimo, J.L. Vonesch, P. Dolle, and P. Chambon. 1994. Genetic analysis of RXR α developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 78:987-1003.
15. Kessel, M. 1992. Respecification of vertebral identities by retinoic acid. Development. 115:487-501.
16. Kessel, M., and P. Gruss. 1988. Open reading frames and translational control. Nature (Lond). 332:117-118.
17. Kessel, M., and P. Gruss. 1991. Homeotic transformation of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell. 67: 89-104.
18. Kochhar, D.M. 1967. Teratogenic activity of retinoic acid. Acta path, et microbiol. scandinav. 70:398-404.
19. Kozak, M. 1984. Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. Nucleic Acids Res. 12:3873-3893.
20. Kozak, M. 1986. Influence of mRNA secondary structure on initiation by eukaryotic ribosomes. Prc. Natl. Acad. Sci. USA. 83:2850-2854.
21. Kozak, M. 1987. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol. Cell. Biol. 7:3438-3445.
22. Kozak, M. 1989a. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
23. Kozak, M. 1989b. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol. Cell. Biol. 9:5134-5142.
24. Kozak, M. 1991a. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266:19867-19870.
25. Kozak, M. 1991b. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:887-903.
26. Mendelsohn, C., D. Lohnes, D. Decimo, T. Lufkin, M. LeMeur, P. Chambon, and M. Mark. 1994. Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development. 120:2749-2771.
27. Miller, P.F., and A.G. Hinnebusch. 1989. Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control. Genes Dev. 3:1217-1225.
28. Molkentin, J.D., D.V. Kalvakolanu, and B.E. Markham. 1994. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the α-myosin heavy-chain gene. Mol. Cell. Biol. 14:4947/-4957.
29. Mueller, P.P., and A.G. Hinnebusch. 1986. Multiple upstream AUG codons mediate translational control of GCN4. Cell. 45:201-207.
30. Peabody, D.S., and P. Berg. 1986. Termination-reinitiation occurs in the translation of mammalian cell mRNAs. Mol. Cell. Biol. 6:2695-2703.
31. Pelletier, J., and N. Sonenberg. 1985. Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell. 40:515-526.
32. Reynolds, K., E. Mezey, and A. Zimmer. 1991. Activity of the β-retinoic acid receptor promoter in transgenic mice. Mech. Dev. 36:15-29.
33. Schleiss, M.R., C.R. Degnin, and A.P. Geballe. 1991. Translational control of human cytomegalovirus gp48 expression. J. Virol. 65:6782-6789.
34. Sucov, H.M., E. Dyson, C.L. Gumeringer, J. Price, K.R. Chien, and R.M. Evans. 1994. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 8:1007-1018.
35. Twal, W., L. Roze, and M.H. Zile. 1995. Anti-retinoic acid monoclonal antibody localizes all-trans-retinoic acid in target cells and blocks normal development in early quail embryo. Dev. Biol. 168:225-234.
36. Werner, M., A. Feller, F. Messenguy, and A. Pierard. 1987. The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression. Cell. 49:805-813.
37. Wiens, D.J., T.K. Mann, D.E. Fedderson, W.K. Rathmell, and B.H. Franck. 1992. Early heart development in the chick embryo: effects of isotretinoin on cell proliferation, α-actin synthesis, and development of contractions. Differentiation. 51:105-112.
38. Williams, N.P., P.P. Mueller, and A.G. Hinnebusch. 1988. The positive regulatory function of the 5′-proximal open reading frames in GCN4 mRNA can be mimicked by heterologous, short coding sequences. Mol. Cell. Biol. 8: 3827-3836.
39. Wu, J., M. Garami, L. Cao, Q. Li, and D.G. Gardner. 1995. 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am. J. Physiol. 268:E1108-1113.
40. Yutzey, K.E., J.T. Rhee, and D. Bader. 1994. Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart. Development. 120:871-883.
41. Zelent, A., C. Mendelsohn, P. Kastner, A. Krust, J.M. Garnier, F. Ruffenbach, P. Leroy, and P. Chambon. 1991. Differentially expressed isoforms of the mouse retinoic acid receptor β generated by usage of two promoters and alternative splicing. EMBO (Eur. Mol. Biol. Organ.) J. 10:71-81.
42. Zhou, M.D., H.M. Sucov, R.M. Evans, and K.R. Chien. 1995. Retinoid-dependent pathways suppress myocardial cell hypertrophy. Proc. Natl. Acad. Sci. USA. 92:7391-7295.
43. Zimmer, A., and A. Zimmer. 1992. Induction of a RARβ2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system. Development. 116:977-983.
44. Zimmer, A., A.M. Zimmer, and K. Reynolds. 1994. Tissue specific expression of the retinoic acid receptor-β2: regulation by short open reading frames in the 5′-noncoding region. J. Cell Biol. 127:1111-1119.
45. Zuker, M. 1989. Computer prediction of RNA structure. Methods Enzymol. 180:262-288.