메뉴 건너뛰기




Volumn 2, Issue 12, 1996, Pages 1354-1360

Defective post-thymic tolerance mechanisms during the chronic progressive stage of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CLONE; CLONAL ANERGY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029822018     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1296-1354     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 0025358777 scopus 로고
    • Autoimmune diseases: The failure of self tolerance
    • Sinha, A.A., Lopez, M.T. & McDevitt, H.O. Autoimmune diseases: The failure of self tolerance. Science 248, 1380-1387 (1990).
    • (1990) Science , vol.248 , pp. 1380-1387
    • Sinha, A.A.1    Lopez, M.T.2    McDevitt, H.O.3
  • 3
    • 0023948785 scopus 로고
    • Mutual cell interactions and the selection of immune repertoires: Implication in autoimmunity
    • Marcos, M.A.R. et al. Mutual cell interactions and the selection of immune repertoires: Implication in autoimmunity. Immunol. Today 9, 204-213 (1988).
    • (1988) Immunol. Today , vol.9 , pp. 204-213
    • Marcos, M.A.R.1
  • 4
    • 0024372111 scopus 로고
    • Acquisition of immunological self-tolerance
    • Schwartz, R.H. Acquisition of immunological self-tolerance. Cell 57, 1073-1081 (1989).
    • (1989) Cell , vol.57 , pp. 1073-1081
    • Schwartz, R.H.1
  • 5
    • 0025368646 scopus 로고
    • The role of the T cell receptor in positive and negative selection of developing T cells
    • Blackman, M., Kappler, J. & Marrack, P. The role of the T cell receptor in positive and negative selection of developing T cells. Science 248, 1335-1341 (1990).
    • (1990) Science , vol.248 , pp. 1335-1341
    • Blackman, M.1    Kappler, J.2    Marrack, P.3
  • 6
    • 0026047598 scopus 로고
    • Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor β-chain transgenic mice
    • Blackman, M.A., Finkel, T.H., Kappler, J.W., Cambier, J. & Marrack, P. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor β-chain transgenic mice. Proc. Natl. Acad. Sci. USA 88, 6682-6686 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6682-6686
    • Blackman, M.A.1    Finkel, T.H.2    Kappler, J.W.3    Cambier, J.4    Marrack, P.5
  • 7
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T cell lines from normal human blood
    • Burns, J., Rosenzweig, A., Zweiman, B. & Lisak, R.P. Isolation of myelin basic protein-reactive T cell lines from normal human blood. Cell. Immunol. 81, 435-440 (1983).
    • (1983) Cell. Immunol. , vol.81 , pp. 435-440
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3    Lisak, R.P.4
  • 8
    • 0029086439 scopus 로고
    • Isolation and characterization of autoreactive proteolipid protein-peptide specific T-cell clones from multiple sclerosis patients
    • Correale, J., McMillan, M., McCarthy, K., Le, T. & Weiner, L.P. Isolation and characterization of autoreactive proteolipid protein-peptide specific T-cell clones from multiple sclerosis patients. Neurology 45, 1370-1378 (1995).
    • (1995) Neurology , vol.45 , pp. 1370-1378
    • Correale, J.1    McMillan, M.2    McCarthy, K.3    Le, T.4    Weiner, L.P.5
  • 9
    • 0023837985 scopus 로고
    • Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
    • Kappler, J.W., Staerz, V.D., Steinmetz, M. & von Boehmer, M. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332, 35-40 (1988).
    • (1988) Nature , vol.332 , pp. 35-40
    • Kappler, J.W.1    Staerz, V.D.2    Steinmetz, M.3    Von Boehmer, M.4
  • 10
    • 0025978235 scopus 로고
    • + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta
    • + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta. J. Immunol. 146, 1163-1168 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 1163-1168
    • Karpus, W.J.1    Swanborg, R.H.2
  • 11
    • 0025873509 scopus 로고
    • Cytokine secretion patterns and cross-regulation of T cell subsets
    • Mosmann, T.R. Cytokine secretion patterns and cross-regulation of T cell subsets. Immunol. Res. 10, 183-188 (1991).
    • (1991) Immunol. Res. , vol.10 , pp. 183-188
    • Mosmann, T.R.1
  • 12
    • 0026033502 scopus 로고
    • Autoimmunity, microbial immunity and the immunological homunculus
    • Cohen, I.R. & Young, D.B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol. Today 12, 105-110 (1991).
    • (1991) Immunol. Today , vol.12 , pp. 105-110
    • Cohen, I.R.1    Young, D.B.2
  • 13
    • 0024549385 scopus 로고
    • Induction of classical transplantation tolerance in the adult
    • Qin, S.X., Cobbold, S., Benjamin, R. & Waldmann, H. Induction of classical transplantation tolerance in the adult. J. Exp. Med. 69, 779-794 (1989).
    • (1989) J. Exp. Med. , vol.69 , pp. 779-794
    • Qin, S.X.1    Cobbold, S.2    Benjamin, R.3    Waldmann, H.4
  • 14
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D.L., Jenkins, M.K. & Schwartz, R.H. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445-180 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445-1180
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 15
    • 0025685264 scopus 로고
    • Interferon gamma plays a critical role in induced cell death of effector T cells: A possible third mechanism of self-tolerance
    • Liu, Y. & Janeway, C.A., Jr. Interferon gamma plays a critical role in induced cell death of effector T cells: A possible third mechanism of self-tolerance. J. Exp. Med. 172, 1735-1739 (1990).
    • (1990) J. Exp. Med. , vol.172 , pp. 1735-1739
    • Liu, Y.1    Janeway Jr., C.A.2
  • 16
    • 0025947446 scopus 로고
    • B cell surface antigen B7 provides a costimulatory signal that induces T cell to proliferate and secrete interleukin-2
    • Gimmi, C.D. et al. B cell surface antigen B7 provides a costimulatory signal that induces T cell to proliferate and secrete interleukin-2. Proc. Natl. Acad. Sci. USA 88, 6575-6579 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6575-6579
    • Gimmi, C.D.1
  • 17
    • 0028425450 scopus 로고
    • In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2
    • Chen, C. & Nabvi, N. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity 1, 147-154 (1994).
    • (1994) Immunity , vol.1 , pp. 147-154
    • Chen, C.1    Nabvi, N.2
  • 18
    • 0026778697 scopus 로고
    • Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule
    • Linsley, P.S. et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257, 792-795 (1992).
    • (1992) Science , vol.257 , pp. 792-795
    • Linsley, P.S.1
  • 19
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • Lenschow, D.J. et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181, 1145-1155 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1
  • 20
    • 0031012659 scopus 로고    scopus 로고
    • Antigen presentation by autoreactive proteolipid protein peptide-specific T cell clones from chronic progressive multiple sclerosis patients: Roles of co-stimulatory B7 molecules and IL-12
    • in the press
    • Correale, J. et al. Antigen presentation by autoreactive proteolipid protein peptide-specific T cell clones from chronic progressive multiple sclerosis patients: Roles of co-stimulatory B7 molecules and IL-12. J. Neuroimmunol. (in the press).
    • J. Neuroimmunol.
    • Correale, J.1
  • 21
    • 0025058266 scopus 로고
    • Inhibition of antigen specific proliferation of type 1 murine T cell clones after stimulation with antigen and chemically modified antigen presenting cells
    • Jenkins, M.K., Chen, C., Jung, G., Mueller, D.L. & Schwartz, R.H. Inhibition of antigen specific proliferation of type 1 murine T cell clones after stimulation with antigen and chemically modified antigen presenting cells. J. Immunol. 144, 16-22 (1990).
    • (1990) J. Immunol. , vol.144 , pp. 16-22
    • Jenkins, M.K.1    Chen, C.2    Jung, G.3    Mueller, D.L.4    Schwartz, R.H.5
  • 22
    • 0026660731 scopus 로고
    • Antigen receptor mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns
    • Williams, M.E., Shea, C.M., Lichtman, A.H. & Abbas, A.K. Antigen receptor mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns. J. Immunol. 149, 1921-1926 (1991).
    • (1991) J. Immunol. , vol.149 , pp. 1921-1926
    • Williams, M.E.1    Shea, C.M.2    Lichtman, A.H.3    Abbas, A.K.4
  • 23
    • 0025223870 scopus 로고
    • Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins
    • O'Hehir, R.E. & Lamb, J.R. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc. Natl. Acad. Sci. USA 87, 8884-8888 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8884-8888
    • O'Hehir, R.E.1    Lamb, J.R.2
  • 24
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M.K & Schwartz, R.H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 25
    • 0028803549 scopus 로고
    • Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rat through a partial reversible anergy mechanism
    • Vandenbark, A.A, Celnik, B., Vainiene, M., Miller, S.D. & Offner, H. Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rat through a partial reversible anergy mechanism. J. Immunol. 155, 5861-5867 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 5861-5867
    • Vandenbark, A.A.1    Celnik, B.2    Vainiene, M.3    Miller, S.D.4    Offner, H.5
  • 26
    • 0027397169 scopus 로고
    • Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
    • Tan, P. et al. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177, 165-173 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 165-173
    • Tan, P.1
  • 27
    • 0028903939 scopus 로고
    • CD28-B7 blockade after alloantigen challenge in vivo inhibits Th1 cytokines but spares Th2
    • Sayegh, M.H. et al. CD28-B7 blockade after alloantigen challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181, 1869-1874 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1869-1874
    • Sayegh, M.H.1
  • 28
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massague, J. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6, 597-641 (1990);
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massague, J.1
  • 29
    • 0028990465 scopus 로고
    • Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases
    • Miller, S.D. et al. Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol. Rev. 144, 225-244 (1995).
    • (1995) Immunol. Rev. , vol.144 , pp. 225-244
    • Miller, S.D.1
  • 30
    • 0026517943 scopus 로고
    • Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
    • Olsson, T. et al. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur. J. Immunol. 22, 1083-1087 (1992).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1083-1087
    • Olsson, T.1
  • 31
    • 0027143640 scopus 로고
    • + T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis
    • + T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151, 7233-7239 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 7233-7239
    • Bossu, P.1
  • 32
    • 0027275101 scopus 로고
    • T cells involved in human autoimmune disease are resistant to tolerance induction
    • Dayan, C.M., Randall Chu, N., Londei, M., Rapoport, B. & Feldmann, M. T cells involved in human autoimmune disease are resistant to tolerance induction. J. Immunol. 151, 1606-1613 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 1606-1613
    • Dayan, C.M.1    Randall Chu, N.2    Londei, M.3    Rapoport, B.4    Feldmann, M.5
  • 33
    • 0029553431 scopus 로고
    • Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
    • Miller, S.D. et al. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3, 739-745 (1995).
    • (1995) Immunity , vol.3 , pp. 739-745
    • Miller, S.D.1
  • 34
    • 0029124687 scopus 로고
    • Lymphocyte costimulation: Multiple pathways, multiple functions?
    • Kuiper, H.M., Lens, S.M.A., Hintzen, R.Q. & Van Lier, R.A.W. Lymphocyte costimulation: Multiple pathways, multiple functions? Res. Immunol. 146, 180-183 (1995).
    • (1995) Res. Immunol. , vol.146 , pp. 180-183
    • Kuiper, H.M.1    Lens, S.M.A.2    Hintzen, R.Q.3    Van Lier, R.A.W.4
  • 36
    • 0026728450 scopus 로고
    • Mechanisms of self tolerance
    • Kroemer, G. & Martinez-A, C. Mechanisms of self tolerance. Immunol. Today 13, 401-404 (1992).
    • (1992) Immunol. Today , vol.13 , pp. 401-404
    • Kroemer, G.1    Martinez-A, C.2
  • 37
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor beta-1
    • Racke, M.K. et al. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor beta-1. J. Immunol. 146, 3012-3017 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 3012-3017
    • Racke, M.K.1
  • 38
    • 0028242737 scopus 로고
    • Loss of receptors for transforming growth factor beta in human T cell malignancies
    • Kadin, M.E. et al. Loss of receptors for transforming growth factor beta in human T cell malignancies. Proc. Natl. Acad. Sci USA 91, 6002-6006 (1994).
    • (1994) Proc. Natl. Acad. Sci USA , vol.91 , pp. 6002-6006
    • Kadin, M.E.1
  • 39
    • 0028179915 scopus 로고
    • Human T cell lymphotropic virus type I-induced T cell activation: Resistance to TGF-beta-1 induced suppression
    • Hollsberg, P., Augobel, L.J. & Hafler, D.A. Human T cell lymphotropic virus type I-induced T cell activation: Resistance to TGF-beta-1 induced suppression. J. Immunol. 153, 566-573 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 566-573
    • Hollsberg, P.1    Augobel, L.J.2    Hafler, D.A.3
  • 40
    • 0021035886 scopus 로고
    • Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke, J.F. Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 33, 1444-1452 (1983).
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.