Arterial versus venous metabolism of nitroglycerin to nitric oxide: A possible explanation of organic nitrate venoselectivity

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 3, 1996, Pages 371-374

  Bauer, John Anthony ^a   Fung, Ho Leung ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Metabolism; Nitric oxide; Nitroglycerin; Organic nitrate; Vascular

Indexed keywords

GLYCERYL TRINITRATE; NITRIC OXIDE;

ANIMAL TISSUE; AORTA; ARTICLE; CATTLE; CAVA VEIN; DRUG METABOLISM; DRUG SELECTIVITY; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; TISSUE SPECIFICITY;

ANIMALS; AORTA; CATTLE; MICROSOMES; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITROGLYCERIN; VASODILATOR AGENTS; VENAE CAVAE;

EID: 0029821992     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199609000-00004     Document Type: Article

References (19)

1. Abrams J. Mechanism of action of nitrates. In: Abrams J, Pepine CJ, Thadani U, eds. Medical therapy of ischemic heart disease. Nitrates, beta blockers and calcium antagonists. Boston: Little Brown, 1992:79-95.
2. Bassenge E, Zanzinger J. Nitrates in different vascular beds, nitrate tolerance, and interactions with endothelial function. Am J Cardiol 1992;70:23B-9B.
3. Bauer JA, Booth BP, Fung H-L. Nitric oxide donors: biochemical pharmacology and therapeutics. In: Ignarro L, Murad F, eds. Nitric oxide: biochemistry, molecular biology, and therapeutic implications. San Diego: Academic Press, 1995:361-81. (Advances in pharmacology; vol.34.)
4. Rosen R, Konig E, Klaus W. Different sensitivities of arteries and veins to glyceryltrinitrate-induced relaxation and tolerance: an in vitro study on isolated vessels from rabbits. Arch Int Pharmacodyn 1987;285:226-37.
5. Mackenzie JE, Parratt JR. Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro: relevance to antianginal activity. Br J Pharmacol 1977;60:155-60.
6. Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide. J Pharmacol Exp Ther 1981;218: 739-49.
7. Marks GS, McLaughlin BE, Brown LB, et al. Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10000 ′ g supernatant: biotransformation and nitric oxide formation. Can J Physiol Pharmacol 1991;69:889-92.
8. Moncada S, Higgs A. The arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
9. Chung S-J, Fung H-L. Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary artery smooth muscle cells. J Pharmacol Exp Ther 1990;253;614-9.
10. Chung S-J, Fung H-L. A common enzyme may be responsible for the conversion of organic nitrates to nitric oxide in vascular microsomes. Biochem Biophys Res Commun 1992; 185:932-7.
11. Chung S-J, Chong S, Seth P, Jung CJ, Fung H-L. Conversion of nitroglycerin to nitric oxide in microsomes of the bovine coronary artery smooth muscle is not primarily mediated by glutathione-S-transferases. J Pharmacol Exp Ther 1992;260:652-8.
12. Bauer JA, Fung H-L. Photochemical generation of nitric oxide from nitro-containing compounds: possible relation to vascular photorelaxation phenomena. Life Sci 1994;54: PL1-4.
13. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
14. 2+ channels in experimental heart failure. Am J Physiol 1991;261:H1979-87.
15. Bennett BM, McDonald BJ, Nigam R, Craig Simon W. Biotransformation of organic nitrates and vascular smooth muscle function. Trends Pharmacol Sci 1994;15:245-9.
16. Chung S-J, Fung H-L. Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development. Biochem Pharmacol 1993;45:157-63.
17. Seth P, Fung H-L. Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells. Biochem Pharmacol 1993;46:1481-6.
18. Fung H-L, Sutton SC, Kimaya A. Blood vessel uptake and metabolism of organic nitrates in the rat. J Pharmacol Exp Ther 1984;228:334-41.
19. Sellke FW, Tomanek RJ, Harrison DG, L-Cysteine selectively potentiates nitroglycerin-induced dilation of small coronary microvessels. J Pharmacol Exp Ther 1991;258:365-9.