Effects of verapamil on acute murine Chagas' disease

Journal of Parasitology

Volumn 82, Issue 5, 1996, Pages 814-819

  Tanowitz, Herbert B ^a   Wittner, Murray ^a   Chen, Bing ^a   Huang, Huan ^a   Weiss, Louis M ^a   Christ, George J ^a   Braunstein, Vicki ^a   Bilezikian, John P ^a   Morris, Stephen A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BEPRIDIL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; ISRADIPINE; NICARDIPINE; NIFEDIPINE; NIMODIPINE; PRAZOSIN; PROPRANOLOL; VERAPAMIL;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; EPIMASTIGOTE; IMMUNOBLOTTING; MORTALITY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; TRYPANOSOMA CRUZI;

ACUTE DISEASE; ADENYLATE CYCLASE; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CHAGAS DISEASE; DILTIAZEM; ENDOTHELIUM, VASCULAR; GTP-BINDING PROTEINS; HUMANS; MALE; MICE; MYOCARDIUM; PRAZOSIN; PROPRANOLOL; TRYPANOSOMA CRUZI; UMBILICAL VEINS; VERAPAMIL;

ANIMALIA; MURINAE; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0029821843     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.2307/3283896     Document Type: Article

References (35)

1. ANDRAWIS, N. S., J. GILLIGAN, AND D. R. ABERNATHY. 1992. Endothelin-1-mediated vasoconstriction: Specific blockade by verapamil. Clinical Pharmacology and Therapeutics 52: 583-589.
2. BILEZIKIAN, J. P, A. M. DORNFIELD, AND D. E. GAMMON. 1978. Structure-binding activity analysis of beta-adrenergic amines. I. Activation of adenylate cyclase. Biochemical Pharmacology 27: 1445-1454.
3. BONADONNA, G., C. LECHI, P. CORRADINI, D. SINIGAGLIA, P. DE TOGNI, AND G. MIROSLAWA. 1986. Verapamil inhibits platelet aggregation by a calcium-independent mechanism. Thrombosis and Haemostasis 56: 308-310.
4. 1 in human platelets. Journal of Biological Chemistry 264: 13298-13305.
5. CHEN, L. E., A. V. SEABER, P. OTTO-HAGEN, AND J. URBANICK. 1993. The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil. Journal of Reconstructive Microsurgery 9: 49-54.
6. DONG, R., P. LIU, L. WEE, J. BUTANY, AND M. J. SOLE. 1992. Verapamil ameliorates the clinical and pathological course of murine myocarditis. Journal of Clinical Investigation 90: 2022-2030.
7. DRICI, M. D., Y. JACOMET, J. P. LACONO, AND P. LABALUS. 1992. Is verapamil also a non-selective beta blocker? International Journal of Clinical Pharmacology, Therapy and Toxicology 31: 27-30.
8. FACTOR, S. M., S. CHO, M. WITTNER AND H. TANOWITZ. 1985. Abnormalities of the coronary microcirculation in acute murine Chagas' disease. American Journal of Tropical Medicine and Hygiene 34: 246-253.
9. _, T. MINASE, S. CHO, R. DOMINITZ, AND E. H. SONNENBLOCK. 1982. Microvascular spasm in the cardiomyopathic hamster: A preventable cause of focal myocardial necrosis. Circulation 66: 342-354.
10. FRISHMAN, W. H., AND E. H. SONNENBLICK. 1994. Calcium channel blockers. In The heart, arteries and veins, R. C. Schalant and R. W. Alexander (eds.). McGraw-Hill, New York, New York, p. 1291-1308.
11. GARBRECHT, M., AND U. MULLERLEILE. 1986. Verapamil in the prevention of adriamycin-induced cardiomyopathy. Klinische Wochenschrift 64: 132-134.
12. GLAUBIGER, G., AND R. J. LEFKOWITZ. 1977. Elevated beta-adrenergic receptor number after chronic propranolol treatment. Biochemical and Biophysical Research Communication 78: 720-725.
13. HARRIS, C., M. P. SALGO, H. B. TANOWITZ, AND M. WITTNER. 1987. In vitro assessment of antimicrobial agents against Toxoplasma gondii. Journal of Infectious Diseases 157: 14-22.
14. HIGHSMITH, R. F., K. BLACKBURN, AND D. J. SCHMIDT. 1992. Endothelin and calcium dynamics in vascular smooth muscle. Annual Review of Physiology 54: 257-277.
15. LEVIN, E. R. 1995. Endothelins. New England Journal of Journal of Medicine 333: 356-363.
16. LIU, P., E. E. L. WANG, AND M. SOLE. 1993. Viral myocarditis: Changing concepts in pathogenesis and implications in diagnosis and treatment. Cardiovascular Pathology 2: 247-257.
17. MARIN-NETO, J. A., P. MARZULLO, C. MARCASSA, J. L. GALLO, B. C. MACIEL, C. R. BELLINE, AND A. L'ABBATE. 1992. Myocardial perfusion abnormalities in chronic Chagas' disease detected by Thalliun-201 scintography. American Journal of Cardiology 69: 780-784.
18. MORRIS, S. A., J. P. BILEZIKIAN, V. HATCHER, L. WEISS, H. B. TANOWITZ, AND M. WITTNER. 1989. Trypanosoma cruzi: Infection of cultured human endothelial cells alters inositol phosphate synthesis. Experimental Parasitology 69: 330-339.
19. _, H. B. TANOWITZ, S. M. FACTOR, J. P. BILEZIKIAN, AND M. WITTNER. 1988a. Alterations in intracellular calcium following infection of human endothelial cells with Trypanosoma cruzi. Molecular and Biochemical Parasitology 29: 213-221.
20. _, _, _, _, AND _. 1988b. Myocardial adenylate cyclase activity in acute murine Chagas' disease. Circulation Research 62: 800-810.
21. _, _, M. WITTNER, AND J. P. BILEZIKIAN. 1992. Pathophysiological insights into the cardiomyopathy of Chagas' disease. Circulation 82: 1900-1909.
22. _, L. M. WEISS, S. M. FACTOR, J. P. BILEZIKIAN, H. B. TANOWITZ, AND M. WITTNER. 1989. Verapamil ameliorates clinical, pathological and biochemical manifestations of experimental chagasic cardiomyopathy in mice. Journal of the American College of Cardiology 14: 782-789.
23. 2-adrenergic receptors. Circulation Research 52: 226-231.
24. ROULEAU, J. L., L. H. CHUCK, G. HOLLOSI, P. KIDD, R. E. SIEVERS, J. WIKMAN-COFFELT, AND W. W. PARMLEY. 1983. Verapamil preserves myocardial contractility in the hereditary cardiomyopathy of the Syrian hamster. Circulation Research 50: 405-412.
25. ROWIN, K. R., H. B. TANOWITZ, M. WITTNER, H. T. NGUYEN, AND B. NADAL-GINARD. 1983. Inhibition of muscle differentiation by Trypanosoma cruzi. Proceedings of the National Academy of Sciences USA 83: 6390-6394.
26. SALOMON, Y., C. LONDOS, AND M. RODBELL. 1974. A highly sensitive adenylate cyclase assay. Analytical Biochemistry 58: 541-548.
27. TANOWITZ, H. B., E. R. BURNS, A. K. SINHA, N. N. KAHN, S. A. MORRIS, S. M. FACTOR, V. B. HATCHER, J. P. BILEZIKIAN, AND M. WITTNER. 1990. Enhanced platelet adherence and aggregation in Chagas' disease: A potential pathogenic mechanism for cardiomyopathy. American Journal of Tropical Medicine and Hygiene 43: 274-281.
28. _, J. P. GUMPRECHT, D. SPURR, T. M. CALDERON, M. C. VENTURA, C. RAVENTOS-SUAREZ, S. M. FACTOR, V. HATCHER, M. WITTNER, AND J. W. BERMAN. 1992. Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi. Journal of Infectious Diseases 166: 598-603.
29. _, D. K. KAUL, B. CHEN, S. A. MORRIS, S. M. FACTOR, L. M. WEISS, AND M. WITTNER. 1996. Compromised microcirculation in acute murine Trypanosoma cruzi infection. Journal of Parasitology 82: 124-130.
30. _, L. V. KIRCHHOFF, D. SIMON, S. A. MORRIS, L. M. WEISS, AND M. WITTNER. 1992. Chagas' disease. Clinical Microbiological Reviews 5: 400-419.
31. _, S. A. MORRIS, S. M. FACTOR, L. M. WEISS, AND M. WITTNER. 1992. Parasitic diseases of the heart I. Acute and chronic Chagas' disease. Cardiovascular Pathology 1: 7-15.
32. _, _, L. M. WEISS, J. P. BILEZIKIAN, S. M. FACTOR, AND M. WITTNER. 1989. Effect of verapamil on the development of chronic experimental Chagas' disease. 1989. American Journal of Tropical Medicine and Hygiene 41: 643-649.
33. 2+. Journal of Experimental Medicine 179: 1017-1022.
34. WILLIAMS, A. G., M. J. WOULKALIS, M. PONEZ, D. R. MANNING, A. M. GEWIRTZ, AND L. F. BRASS. 1990. Identification of the pertussis toxin sensitive G proteins in platelets, megakaryocytes and human erythroleukemia cells. Blood 76: 721-730.
35. WITTNER, M. G., J. CHRIST, H. HUANG, L. M. WEISS, V. B. HATCHER, S. A. MORRIS, G. A. ORR, J. W. BERMAN, G. A. ZEBALLOS, S. A. DOUGLAS, AND H. B. TANOWITZ. 1995. Trypanosoma cruzi induces endothelin release from endothelial cells. Journal of Infectious Diseases 171: 493-497.