Studies directed toward the synthesis of ulapualide A. Asymmetric synthesis of the C26-C42 fragment

Journal of Organic Chemistry

Volumn 61, Issue 19, 1996, Pages 6494-6495

  Panek, James S ^a   Beresis, Richard T ^a   Celatka, Cassandra A ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ULAPUALIDE A; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0029821708     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo960531z     Document Type: Article

References (22)

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11. For earlier synthetic studies see (a) Chattopadhyay, S. K.; Pattenden, G. Tetrahedron Lett. 1995, 36, 5271-5274. (b) Pattenden, G. J. Heterocycl. Chem. 1992, 29, 607-618.
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13. For preparation of silane (S)-I and (S)-15, see supporting information.
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16. 1H-NMR.
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22. Aldehyde 14 was condensed with silane (R)-15 under similar conditions, to afford 20 in 84% yield and excellent syn diastereoselection. equation presented