The membrane-cytoplasm interface of integrin α subunits is critical for receptor latency

Molecular Biology of the Cell

Volumn 7, Issue 10, 1996, Pages 1499-1509

  Briesewitz, Roger ^a   Kern, Andreas ^a   Smilenov, Lubomir B ^a   David, Frank S ^a   Marcantonio, Eugene E ^a,b  

^a The New York Presbyterian Hospital   (United States)

^b Black Building 1427 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CYTOSKELETON; EXTRACELLULAR MATRIX; HYPOTHESIS; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR POTENTIAL;

EID: 0029821677     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.10.1499     Document Type: Article

References (36)

1. 1 subunit. J. Biol. Chem. 268, 2989-2996.
2. Briesewitz, R., Kern, A., and Marcantonio, E.E. (1993b). Ligand-dependent and independent integrin focal contact localization: the role of the α chain cytoplasmic domain. Mol. Biol. Cell 4, 593-604.
3. Briesewitz, R., Kern, A., and Marcantonio, E.E. (1995). Assembly and function of integrin receptors is dependent on opposing α and β cytoplasmic domains. Mol. Biol. Cell 6, 997-1010.
4. Burridge, K., Fath, K., Kelly, T., Nuckolls, G., and Turner, C. (1988). Focal adhesion: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4, 487-525.
5. Chen, Q., Kinch, M.S., Lin, T.S., Burridge, K., and Juliano, R.L. (1994). Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
6. Chen, W.T., Hasegawa, C., Weinstock, C., and Yamada, K.M. (1985). Development of cell surface linkage complexes in cultivated fibroblasts. J. Cell Biol. 100, 1103-1114.
7. Damsky, C.M., Knudsen, K.A., Bradley, D., Buck, C.A., and Horwitz, A.F. (1985). Distribution of the CSAT cell-matrix antigen on myogenic and fibroblastic cells in culture. J. Cell Biol. 100, 1528-1539.
8. Dejana, E., Colella, S., Conforti, G., Abbadini, M., Gaboli, M., and Marchisio, P.C. (1988). Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. J. Cell Biol. 107, 1215-1223.
9. 1-integrin receptor which localizes to both cell-cell and cell-matrix adhesions. J. Cell Sci. 103, 943-951.
10. Guadagno, T.M., and Assoian, R.K. (1991). G1/S control of anchorage-independent growth in the fibroblast cell cycle. J. Cell Biol. 115, 1419-1425.
11. Guadagno, T.M., Ohtsubo, M., Roberts, J.M., and Assoian, R.K. (1993). A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572-1575.
12. Hartman, S.C., and Mulligan, R.C. (1988). Two dominant-acting selectable markers for gene transfer studies in mammalian cells. Proc. Natl. Acad. Sci. USA 85, 8047-8051.
13. 1 subunit and its cytoplasmic domain mutants in mouse NIH-3T3 cells. J. Cell Biol. 110, 175-184.
14. Horwitz, A.F., Duggan, E., Buck, C., Beckerle, M.C., and Burridge, K. (1986). Interaction of plasma membrane fibronectin receptor with talin-a transmembrane linkage. Nature 320, 531-533.
15. FAK. J. Cell Biol. 122, 473-483.
16. Hughes, P.E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J.A., Shattil, S.J., and Ginsberg, M.H. (1996). Breaking the integrin hinge. J. Biol. Chem. 271, 6571-6574.
17. Hynes, R.O. (1973). Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc. Natl. Acad. Sci. USA 70, 3170-3174.
18. 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol. Biol. Cell 5, 977-988.
19. 1. J. Biol. Chem. 269, 22811-22816.
20. Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227, 680-685.
21. LaFlamme, S.E., Akiyama, S.K., and Yamada, K.M. (1992). Regulation of fibronectin receptor distribution. J. Cell Biol. 117, 437-447.
22. LaFlamme, S.E., Thomas, L.A., Yamada, S.S., and Yamada, K.M. (1994). Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J. Cell Biol. 126, 1287-1298.
23. 1 integrin cytoplasmic domain. J. Biol. Chem. 269, 18311-18314.
24. 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J. Cell Biol. 106, 1765-1772.
25. 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul. 1, 597-604.
26. Miyamoto, S., Akiyama, S.K., and Yamada, K.M. (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
27. 1 integrin subunit in vitro. J. Cell Biol. 111, 721-729.
28. 1 cytoplasmic domain implicated in cytoskeletal association. J. Cell Biol. 117, 1321-1329.
29. Singer, I.I., Scott, S., Kawka, D.W., Kazazis, D.M., Gailit, J., and Ruoslahti, E. (1988). Cell surface distribution of fibronectin and vitronectin receptor depends on substrate composition and extracellular matrix accumulation. J. Cell Biol. 106, 2172-2182.
30. Smith, S.O., Smith, C.S., and Bormann, B.J. (1996). Strong hydrogen bonding interactions involving a buried glutamic acid in the trans-membrane sequence of the neu/erbB-2 receptor. Nat. Struct. Biol. 3, 252-258.
31. 1 cytoplasmic domain effects revealed by lysophosphatidic acid treatment. Mol. Biol. Cell 5, 1215-1223.
32. Solowska, J., Guan, J.-L., Marcantonio, E.E., Trevethick, J.E., Buck, C.A., and Hynes, R.O. (1989). Expression of normal and mutant avian integrin subunits in rodent cells. J. Cell Biol. 109, 853-861.
33. Southern, P.J., and Berg, P. (1982). Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1, 327-341.
34. Williams, M.J., Hughes, P.E., O'Toole, T.E., and Ginsberg, M.H. (1994). The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol. 4, 109-112.
35. Ylänne, J., Chen, Y.L., O'Toole, T.E., Loftus, J.C., Takada, Y., and Ginsberg, M.H. (1993). Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J. Cell Biol. 122, 223-234.
36. Zhu, X., and Assoian, R.K. (1995). Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell 6, 273-282.