Restoration of growth hormone (GH) response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty acids

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 11, 1996, Pages 3998-4001

  Pontiroli, A E ^a,b   Manzoni, M F ^a   Malighetti, M E ^a   Lanzi, R ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; FATTY ACID; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; ELDERLY CARE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; GROWTH REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADULT; AGED; AGING; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; CROSS-OVER STUDIES; FATTY ACIDS, NONESTERIFIED; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; LIPOLYSIS; MALE; OBESITY; PYRAZINES; SINGLE-BLIND METHOD;

EID: 0029821371     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.11.3998     Document Type: Article

References (29)

1. Van Vliet G, Bosson D, Craen M, Du Caju MVL, Malvaux P, Vanderschueren-Lodeweyckx M. 1987 Comparative study of the lipolytic potencies of pituitary-derived and biosynthetic human growth hormone in hypopituitary children. J Clin Endocrinol Metab. 65:876-879.
2. Casanueva FF, Villanueva L, Dieguez C, et al. 1987 Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. J Clin Endocrinol Metab. 65:634-642.
3. Imaki T, Shibasaki T, Masuda A, et al. 1986 The effect of glucose and free fatty acids on growth hormone (GH)-releasing factor-mediated GH secretion in rats. Endocrinology. 118:2390-2394.
4. Fuccella L, Goldaniga G, Lovisolo P, et al. 1980 Inhibition of lipolysis by nicotinic acid and by acipimox. Clin Pharmacol Ther. 28:790-795.
5. Stirling C, McAleer M, Reckless JP, et al. 1985 Effect of acipimox, a nicotinic acid derivative, on lipolysis in human adipose tissue and on cholesterol synthesis in human jejunal mucosa. Clin Sci. 68:83-88.
6. Pontiroli AE, Lanzi R, Monti LD, Pozza G. 1990 Effect of acipimox, a lipid lowering drug, on growth hormone (GH) response to GH-releasing hormone in normal subjects. J Endocrinol Invest. 13:539-542.
7. Veldhuis JD, Iranmanesh A, Ho KKY, Waters MJ, Johnson ML, Lizarralde G. 1991 Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 72:51-59.
8. Opie LH, Walfish PG. 1963 Plasma free fatty acid concentration in obesity. N Engl J Med. 268:757-760.
9. Golay A, Swislocki AL, Chen YD, Jaspan JB, Reaven GM. 1986 Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentration. J Clin Endocrinol Metab. 63:481-484.
10. Van Coevorden A, Mockel J, Laurent E, et al. 1991 Neuroendocrine rhythms and sleep in aging men. Am J Physiol. 260:E651-E661.
11. Vermeulen A. 1987 Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels. J Clin Endocrinol Metab. 64:884-888.
12. Gil-Ad I, Gurewitz R, Marcovici O, Rosenfeld J, Laron Z. 1984 Effects of aging on human plasma growth hormone response to clonidine. Mech Ageing Dev. 27:97-100.
13. Bando H, Zhang C, Takada Y, Yamasaki R, Saito S. 1991 Impaired secretion of growth hormone-releasing hormone, growth hormone and IGF-1 in elderly men. Acta Endocrinol (Copenh). 124:31-36.
14. Kalk WJ, Vinik AI, Pimstone BL, Jackson PU. 1973 Growth hormone response to insulin hypoglycemia in the elderly. J Gerontol. 28:431-433.
15. Shibasaki T, Shizume K, Nakahara M, et al. 1984 Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J Clin Endocrinol Metab. 58:212-214.
16. Dudl RJ, Ensinck JW, Palmer HE, Williams RH. 1973 Effect of age on growth hormone secretion in man. J Clin Endocrinol Metab. 37:11-16.
17. Viberti G, Pontiroli AE, Mignani E, Tognetti A, Mango S, Pozza G. 1974 Effect of ageing on insulin and growth hormone response to glucose and arginine in normal subjects. Acta Diabetol Lat. 11:432-436.
18. Ghigo E, Goffi S, Nicolosi M, et al. 1990 Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J Clin Endocrinol Metab. 71:1481-1485.
19. Bonadonna RC, Groop LC, Simonson DC, DeFronzo RA. 1994 Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle. Am J Physiol 266:E501-509.
20. Rosenthal MJ, Woodside W. 1988 Nocturnal regulation of free fatty acids in healthy young and elderly men. Metabolism. 37:645-648.
21. Sandberg H, Yoshimine N, Maeda S, Symons D, Zavodnick J. 1973 Effects of an oral glucose load on serum immunoreactive insulin, free fatty acid, growth hormone and blood sugar levels in young and elderly subjects. J Am Geriatr Soc. 21:433-439.
22. Pontiroli AE, Lanzi R, Monti LD, Sandoli E, Pozza G. 1991 Growth hormone (GH) autofeedback on GH response to GH-releasing hormone. Role of free fatty acids and somatostatin. J Clin Endocrinol Metab. 72:492-495.
23. Fulcher GR, Walker M, Faner M, Johnson AS, Alberti KGMM. 1993 Acipimox increases glucose disposal in normal men independent of changes in plasma nonesterified fatty acid concentration and whole-body lipid oxidation rate. Metabolism. 42:308-314.
24. Ghigo E, Goffi S, Arvat E, et al. 1990 Pyridostigmine partially restores the GH responsiveness to GHRH in normal aging. Acta Endocrinol (Copenh). 123:169-173.
25. Worm D, Henriksen JE, Vaag A, Thye-Ronn P, Melander A, Beck-Nielsen H. 1994 Pronounced blood glucose-lowering effect of the antilipolytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period. J Clin Endocrinol Metab. 78:717-721.
26. Piatti PM, Monti LD, Pacchioni M, Pontiroli AE, Pozza G. 1991 Forearm insulin- and non-insulin-mediated glucose uptake and muscle metabolism in man: role of free fatty acids and blood glucose levels. Metabolism. 40:926-933.
27. Melmed S. 1984 Insulin suppresses growth hormone secretion by rat pituitary cells. J Clin Invest. 73:1425-1433.
28. Ceda GP, Hoffman AR, Silverberg GD, Wilson DM, Rosenfeld RG. 1985 Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin. J Clin Endocrinol Metab. 60:1204-1209.
29. Møller N, Schmitz O, Pørksen N, Møller J, Jorgensen JO. 1992 Dose-response studies on the metabolic effects of a growth hormone pulse in humans. Metabolism. 41:172-175.