Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 8, 1996, Pages 1941-1944

  Klepser, Michael E ^a,b,d   Banevicius, Mary Anne ^a   Quintiliani, Richard ^a,c   Nightingale, Charles H ^a,b  

^a HARTFORD HOSPITAL   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN;

ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BACTERIUM ISOLATION; BACTEROIDES FRAGILIS; COLONY FORMING UNIT; CONTROLLED STUDY; INOCULATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; POWDER; PRIORITY JOURNAL;

EID: 0029820947     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.8.1941     Document Type: Article

References (26)

1. Aldridge, K. E., and C. W. Stratton. 1991. Bactericidal activity of ceftizoxime, cefotetan, and clindamycin against cefoxitin-resistant strains of the Bacteroides fragilis group. J. Antimicrob. Chemother. 28:701-705.
2. Ameer, B., P. Sesin, and A. W. Karchmer. 1987. Selecting clindamycin dosing regimens. Am. J. Hosp. Pharm. 44:2027-2028.
3. Begg, E. J., B. A. Peddie, S. T. Chambers, and D. R. Boswell. 1992. Comparison of gentamicin dosing regimens using an in-vitro model. J. Antimicrob. Chemother. 29:427-433.
4. Buchwald, D., S. B. Soumerai, N. Vandevanter, M. R. Wessels, and J. Avorn. 1989. Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome. Rev. Infect. Dis. 11:619-624.
5. Bundtzen, R. W., A. U. Gerber, D. L. Cohn, and W. A. Craig. 1981. Postantibiotic suppression of bacterial growth. Rev. Infect. Dis. 3:28-37.
6. Chin, A., M. A. Gill, M. K. Ito, A. E. Yellin, T. V. Berne, P. N. R. Heseltine, M. D. Appleman, and F. C. Chenella. 1989. Evaluation of two different dosage regimens of clindamycin and the penetration into human appendix. Ther. Drug Monit. 11:421-424.
7. Craig, W. A., and S. C. Ebert. 1991. Killing and regrowth of bacteria in vitro: a review. Scand. J. Infect. Dis. Suppl. 74:147-154.
8. Davis, B. D. 1987. Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 51:341-350.
9. Drusano, G. L. 1991. Human pharmacodynamics of beta-lactams, aminoglycosides and their combinations. Scand. J. Infect. Dis. Suppl. 74:235-248.
10. Flaherty, J. F., L. C. Rodondi, B. J. Guglielmo, J. C. Fleishaker, R. J. Townsend, and J. G. Gambertoglio. 1988. Comparative pharmacokinetics and serum inhibitory activity of clindamycin in different dosing regimens. Antimicrob. Agents Chemother. 32:1825-1829.
11. Isaksson, B., L. Nilsson, R. Maller, and L. Sörén. 1988. Postantibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method. J. Antimicrob. Chemother. 22:23-33.
12. Klepser, M. E., M. A. Banevicius, R. Quintiliani, and C. H. Nightingale. 1995. Characterization of the bactericidal activities of clindamycin, metronidazole, and piperacillin/tazobactam against Bacteroides fragilis. Pharmacotherapy 15:123. (Abstract 101.)
13. Klepser, M. E., D. P. Nicolau, R. Quintiliani, and C. H. Nightingale. 1996. Comparison of the bactericidal activity of clindamycin administered every eight and twelve hours against Staphylococcus aureus, Streptococcus pneumoniae, and Bacteroides fragilis. Pharmacotherapy 16:501. (Abstract 74.)
14. Leggett, J. E., B. Fantin, S. Ebert, K. Totsuka, B. Vogelman, W. Calame, H. Mattie, and W. A. Craig. 1989. Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models. J. Infect. Dis. 159:281-292.
15. Livingston, D. H., and M. T. Wang. 1993. Continuous infusion of cefazolin is superior to intermittent dosing in decreasing infection after hemorrhagic shock. Am. J. Surg. 165:203-207.
16. Mordenti, J. J., R. Quintiliani, and C. H. Nightingale. 1985. Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model. J. Antimicrob. Chemother. 15(Suppl. A):313-321.
17. National Committee for Clinical Laboratory Standards. 1990. Methods for antimicrobial susceptibility testing of anaerobic bacteria. Approved standard M11-82. National Committee for Clinical Laboratory Standards, Villanova, Pa.
18. Nicolau, D. P., C. D. Freeman, P. P. Belliveau, C. H. Nightingale, J. W. Ross, and R. Quintiliani. 1995. Experience with a once-daily aminoglycoside program administered to 2,184 adult patients. Antimicrob. Agents Chemother. 39:650-655.
19. Nishida, M., T. Murakawa, T. Kamimura, and N. Okada. 1978. Bactericidal activity of cephalosporins in an in vitro model simulating serum levels. Antimicrob. Agents Chemother. 14:6-12.
20. Onyeji, C. O., D. P. Nicolau, C. H. Nightingale, and R. Quintiliani. 1994. Optimal times above MICs of ceftibuten and cefaclor in experimental intraabdominal infections. Antimicrob. Agents Chemother. 38:1112-1117.
21. Plaisance, K. I., G. L. Drusano, A. Forrest, R. J. Townsend, and H. C. Standiford. 1989. Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate. Antimicrob. Agents Chemother. 33:618-620.
22. Roosendaal, R., I. A. J. M. Bakker-Woudenburg, J. C. van den Berg, and M. F. Michel. 1985. Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in an experimental Klebsiella pneumoniae pneumonia in rats. J. Infect. Dis. 152:373-378.
23. Stratton, C. W., L. S. Weeks, and K. E. Aldridge. 1987. Comparison of kill-kinetic studies with agar and broth microdilution methods for determination of antimicrobial activity of selected agents against members of the Bacteroides fragilis group. J. Clin. Microbiol. 25:645-649.
24. Townsend, R. J., and R. P. Baker. 1987. Pharmacokinetic comparison of three clindamycin phosphate dosing schedules. Drug Intell. Clin. Pharm. 21:279-281.
25. Vogelman, B., S. Gudmundsson, J. Turnidge, J. Leggett, and W. A. Craig. 1988. In vivo postantibiotic effect in a thigh infection in neutropenic mice. J. Infect. Dis. 157:287-298.
26. Zeisler, J. A., J. D. McCarthy, W. A. Richelieu, and M. B. Nichol. 1992. Cefuroxime by continuous infusion: a new standard of care? Infect. Med. 11:54-60.