Mutational analysis of ICP0R, a transrepressor protein created by alternative splicing of the ICP0 gene of herpes simplex virus type 1

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7360-7370

  Spatz, Stephen J ^a   Nordby, Eric C ^a   Weber, Peter C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY PROTEIN; POLYPEPTIDE; REPRESSOR PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; HERPES SIMPLEX VIRUS 1; IMMEDIATE EARLY GENE; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; TRANSACTIVATION; VERO CELL; VIRUS GENE; VIRUS MUTANT;

EID: 0029820580     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7360-7370.1996     Document Type: Article

References (57)

1. Barlow, P. N., B. Luisi, A. Milner, M. Elliott, and R. Everett 1994. Structure of the C3HC4 domain by H-1-nuclear magnetic resonance spectroscopy - a new structural class of zinc-finger. J. Mol. Biol. 237:201-211.
2. Borden, K. L. B., M. N. Boddy, J. Lally, N. J. Oreilly, S. Martin, K. Howe, E. Solomon, and P. S. Freemont. 1995. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J. 14:1532-1541.
3. Cai, W., and P. A. Schaffer. 1989. Herpes simplex virus type 1 ICPO plays a critical role in the dc novo synthesis of infectious virus following transfection of viral DNA. J. Virol. 63:4579-4589.
4. Cai, W. H., T. L. Astor, L. M. Liptak, C. Cho, D. M. Coen, and P. A. Schaffer. 1993. The herpes simplex virus type 1 regulatory protein ICPO enhances virus replication during acute infection and reactivation from latency. J. Virol. 67:7501-7512.
5. Chen, J., X. Zhu. and S. Silverstein. 1991. Mutational analysis of the sequence encoding ICPO from herpes simples virus type 1. Virology 180:207-220.
6. Cheung, A. K. 1991. Cloning of the latency gene and early protein 0 gene of pseudorabies virus. J. Virol. 65:5260-5271.
7. Ciufo, D. M., M. A. Mullen, and G. S. Hayward. 1994. Identification of a dimerization domain in the C-terminal segment of the IE110 transactivator protein from herpes simplex virus, J. Virol. 68:3267-3282.
8. Clements, G. B., and N. D. Stow. 1989. A herpes simplex virus type 1 mutant containing a deletion within immediate early gene 1 is latency-competent in mice. J. Gen. Virol. 70:2501-2506.
9. Davison, A. J., and J. E. Scott. 1986. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67:1759-1816.
10. Everett, R., A. Orr, and M. Elliott. 1995. The equine herpesvirus 1 gene 63 RING finger protein partially complements Vmw110, its herpes simplex virus type 1 counterpart. J. Gen. Virol. 76:2369-2374.
11. Everett, R. D. 1984. Transactivation of transcription by herpes virus products: requirement for two HSV-1 immediate early polypeptides for maximum activity. EMBO J. 3:3135-3141.
12. Everett, R. D. 1987. A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1. EMBO J. 6:2069-2076.
13. Everett, R. D. 1988. Analysis of functional domains of herpes simplex virus type 1 immediate early polypeptide Vmw110. J. Mol. Biol. 202:87-96.
14. Everett, R. D. 1991. Construction and characterization of herpes simplex virus type 1 viruses without introns in immediate early gene 1. J. Gen. Virol. 72:651-659.
15. Everett, R. D., P. Barlow, A. Milner, B. Luisi, A. Orr, G. Hope, and D. Lyon. 1993. A novel arrangement of zinc-binding residues and secondary structure-in the C3HC4 motif on an alpha herpes virus protein family. J. Mol. Biol. 234:1038-1047.
16. Everett, R. D., A. Cross, and A. Orr. 1993. A truncated form of herpes simplex virus type-1 immediate-early protein Vmw110 is expressed in a cell type dependent manner. Virology 197:751-756.
17. Everett, R. D., and G. G. Maul. 1994. HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J. 13:5062-5069.
18. Everett, R. D., G. G. Maul, A. Orr, and M. Elliott. 1995. The cellular RING finger protein PML is not a functional counterpart of the herpes simplex virus type 1 RING finger protein Vmw110. J. Gen. Virol. 76:791-798.
19. Everett, R. D., A. Orr, and M. Elliott. 1991. High level expression and purification of herpes simplex virus type 1 immediate early polypeptide Vmw110. Nucleic Acids Res. 19:6155-6161.
20. Fraefel, C., J. Zeng, Y. Choffat, M. Engels, M. Schwyzer, and M. Ackermann. 1994. Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein Bicpo. J. Virol. 68:3154-3162.
21. Freemont, P. S., I. M. Hanson, and J. Trowsdale. 1991. A novel cysteinc-rich sequence motif. Cell 64:483-484.
22. Gelman, I. H., and S. Silverstein. 1985. Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA 82:5265-5269.
23. Harris, R. A., R. D. Everett, X. Zhu, S. Silverstein, and C. M. Preston. 1989. Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J. Virol. 63:3513-3515.
24. Hay, B. A., D. A. Wassarman, and G. M. Rubin. 1995. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83:1253-1262.
25. Hope, I. A., and K. Struhl. 1986. Functional dissection of a eukaryotic transcriplional activator protein, GCN4 of yeast. Cell 46:885-894.
26. Le, X. F., P. Yang, and K. S. Chang. 1996. Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML. J. Biol. Chem. 271:130-135.
27. Leib, D. A., D. M. Coen, C. L. Bogard, K. A. Hicks, D. R. Yager, D. M. Knipe, K. L. Tyler, and P. A. Schaffer. 1989. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J. Virol. 63:759-768.
28. Lovering, R., I. M. Hanson, K. L. B. Borden, S. Martin, N. J. Oreilly, G. I. Evan, D. Rahman, D. J. C. Pappin, J. Trowsdale, and P. S. Freemont. 1993. Identification and preliminary characterization of a protein motif related to the zinc finger. Proc. Natl. Acad. Sci. USA 90:2112-2116.
29. Ma, J., and M. Ptashne. 1987. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847-853.
30. Maul, G. G., and R. D. Everett. 1994. The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0. J. Gen. Virol. 75:1223-1233.
31. Maul, G. G., H. H. Guldner, and J. G. Spivack. 1993. Modification of discrete nuclear domains induced by herpes simplex virus type-1 immediate early gene-1 product (ICP0). J. Gen. Virol. 74:2679-2690.
32. McGeoch, D. J., C. Cunningham, G. McIntyre, and A. Dolan. 1991. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J. Gen. Virol. 72:3057-3075.
33. Meredith, M., A. Orr, M. Elliott, and R. Everett. 1995. Separation of sequence requirements for HSV-1 Vmw110 multimerisation and interaction with a 135-kDa cellular protein. Virology 209:174-187.
34. Meredith, M., A. Orr, and R. Everett. 1994. Herpes simplex virus type 1 immediate-early protein Vmw110 binds strongly and specifically to a 135-kDa cellular protein. Virology 200:457-469.
35. Moriuchi, H., M. Moriuchi, and J. I. Cohen. 1994. The RING finger domain of the varicella-zoster virus open reading frame 61 protein is required for its transregulatory functions. Virology 205:238-246.
36. Mosca, J. D., D. P. Bednarik, N. B. K. Raj, C. A. Rosen, J. G. Sodroski, W. A. Haseltine, G. S. Hayward, and P. M. Pitha. 1987. Activation of human immunodeficiency virus by herpesvirus infection: identification of a region with in the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 84:7408-7412.
37. Mullen, M. A., D. M. Ciufo, and G. S. Hayward. 1994. Mapping of intracellular localization domains and evidence for colocalization interactions between the IE110 and 1E175 nuclear transactivator proteins of herpes simplex virus. J. Virol. 68:3250-3266.
38. Mullen, M. A., S. Gerstberger, D. M. Ciufo, J. D. Mosca, and G. S. Hayward. 1995. Evaluation of colocalization interactions between the IE110, IE175. and 1E63 transactivator proteins of herpes simplex virus within subcellular punctate structures. J. Virol. 69:476-491.
39. Natarajan, R., S. Deshmane, T. Valyi-Nagy, R. Everett, and N. W. Fraser. 1991. A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency. J. Virol. 65:5569-5573.
40. O'Hare, P., and G. S. Hayward. 1985. Evidence for a direcl role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed early promoters. J. Virol. 53:751-760.
41. Ostrove, J. M., J. Leonard, K. E. Week, A. B. Rabson, and H. E. Gendelman. 1987. Activation of the human immunodeficiency virus by herpes simplex virus type 1. J. Virol. 61:3726-3732.
42. Perry, L. J., F. J. Rixon, R. D. Everett, M. C. Frame, and D. J. McGeoch. 1986. Characterization of the IE110 gene of herpes simplex virus type 1. J. Gen. Virol. 67:2365-2380.
43. Quinlan, M. P., and D. M. Knipe. 1985. Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Mol. Cell. Biol. 5:957-963.
44. Sacks, W. R., and P. A. Schaffer. 1987. Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICPO exhibit impaired growth in cell culture. J. Virol. 61:829-839.
45. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539.
46. Sekulovich, R. E., K. Leary, and R. M. Sandri-Goldin. 1988. The herpes simplex virus type 1 α protein ICP27 can act as a frans-repressor or transactivator in combination with ICP4 and ICPO. J. Virol. 62:4510-4522.
47. Shapira, M., F. L. Homa, J. C. Glorioso, and M. Levine. 1987. Regulation of the herpes simplex virus type 1 late (gamma2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (alpha) 4 and 0 genes. Nucleic Acids Res. 15:3097-3111.
48. Song, H. Y., and D. B. Donner. 1995. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. Biochem. J. 309:825-829.
49. Spatz, S. J., E. C. Nordby, and P. C. Weber. Unpublished data.
50. Stow, N. D., and E. C. Stow. 1986. Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw 110. J. Gen. Virol. 67:2571-2585.
51. Telford, E. A., M. S. Watson, K. McBride, and A. J. Davison. 1992. The DNA sequence of equine herpesvirus-1. Virology 189:304-316.
52. Triezenberg, S. J., R. C. Kingsbury, and S. L. McKnighl 1988. Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression. Genes Dev. 2:718-729.
53. Weber, P. C., J. J. Kenny, and B. Wigdahl. 1992. Antiviral properties of a dominant negative mutant of the herpes simplex virus type-1 regulatory protein-ICP0. J. Gen. Virol. 73:2955-2961.
54. Weber, P. C., and B. Wigdahl. 1992. Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0. J. Virol. 66:2261-2267.
55. Yao, F., and P. A. Schaffer. 1994. Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4. J. Virol. 68:8158-8168.
56. Zhu, X., J. Chen, C. S. H. Young, and S. Silverstein. 1990. Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products. J. Virol. 64:4489-4498.
57. Zhu, Z. M., W. Z. Cai, and P. A. Schaffer. 1994. Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins ICP4 and ICP27 affect the intracellular localization of ICPO. J. Virol. 68:3027-3040.