The rationale for the use of recombinant human growth hormone and insulin-like growth factor-i for catabolic conditions in humans

Hormone Research in Paediatrics

Volumn 46, Issue 4-5, 1996, Pages 202-207

  Haymond, Morey W ^a   Mauras, Nelly ^a  

^a Nemours Children's Clinic Jacksonville   (United States)

Author keywords

Catabolic illnesses; Glucocorticosteroids; Growth hormone; Insulin like growth factor I; Leucine metabolism; Nitrogen balance; Protein metabolism

Indexed keywords

GLUCOCORTICOID; GLUCOSE; LEUCINE; PREDNISONE; RECOMBINANT GROWTH HORMONE; RECOMBINANT SOMATOMEDIN C;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; CATABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; NITROGEN BALANCE; NORMAL HUMAN; NUTRITIONAL SUPPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

GLUCOCORTICOIDS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NUTRITIONAL SUPPORT; PROTEIN DEFICIENCY; PROTEINS; RECOMBINANT PROTEINS;

EID: 0029820529     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000185024     Document Type: Article

References (28)

1. Stein TP: Nutrition and protein turnover: A review, J Parcnter Enter Nutr 1982:6:444-454.
2. Rennie MJ, Itarnson R: Effects of injury, disease, and malnutrition on protein metabolism in man: Unanswered questions, Lancet 1984:1: 323-325.
3. C'uthbertson DP: The disturbance of metabolism produced by bone and non-bony injury, with notes of certain abnormal conditions of bone, Biochcm J 1930:24:144-148.
4. Furono K, Goldberg AL: Influence of calcium and other divalent cations on protein turnover in rat skeletal muscle, Am J Physiol 1986:251: C588-C596.
5. Horber FF, Haymond MW; Human growth hormone prevents the protein catabolic side effects of prednisone in humans, J Clin Invest 1990:86:265-272.
6. Clemmons DR, Williams R, Snyder DK, Underwood LE: Treatment with growth hormone conserves lean body mass during dietary restriction in obese volunteers, J Clin Endocrinol Metab 1987;64:878-883.
7. Kupfcr SR, Underwood I.E, Baxter RC, Clemmons DR: Enhancement of the anabolic effects of growth hormone and insulin-like growth factor 1 by use of both agents simultaneously, J Clin Invest 1993:91:301-396.
8. Arnold J, Campbell IT, Samuels TA, Devlin JC, Green CJ, Hpikin LJ, MacDonald IA, Scrimgeour CM, Smith K, Rennie MJ: Increased whole body protein breakdown prc-dom mantes over increased whole body protein synthesis in multiple organ failure, Clin Sci 1993:84:655-661.
9. Horber FF, Schcidegger JR, Gruenig BE, Frey FI: Evidence of prednisone-induced myopathy is reversed by physical training, J Clin Endocrinol Metab 1985:61:83-88.
10. Horber FF, Scheidegger JR, Gruenig BE, Frey FJ: Thigh muscle mass and function in patients treated with flucocorticoids, Eur J Clin Invest 1985;15:302-307.
11. Tessari P, Inchioslro S, Biolo G, Marescotti MC, Fantin G, Boscarato MT, Merola G, Man-tcro F, Tiengo A: Leucine kinetics and the effects of hyperinsulinemia in patients with Cushing's syndrome, J Clin Endocrinol Metab 1989:68:256-262.
12. Odedra BR, Millward KJ: Effect of corticosterone treatment on muscle protein turnover in adrenalectomized rats and diabetic rats maintained in insulin, Biochcm J 1982:204:663-672.
13. 1JC]phenylalaninc into protein of isolated rat diaphragms, Am J Physiol 1960:198:1111-1114.
14. Simmons PS, Miles JM, Gereich JE, Haymond MW: Increased proteolysis: An effect of increases in plasma cortisol within the physiologic range, J Clin Invest 1984:73:412-420.
15. Beaufrere B, Schwenk WF, Marsh HM, Matthews D, Gerich JF., Haymond MW: Glucocorticoids increase leucine oxidation and impair leucine balance in humans, Am J Physiol 1989; 257:E712-E721.
16. Horber FF, Marsch HM, Haymond MW: Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans, Diabetes 1991;40:141-149.
17. Darmaun D, Matthew DE, Bier DM: Physiological hypercortisolcmia increases proteolysis, glutamine, and alanine production, Am J Physiol 1988;255:E366-E373.
18. Shamoon HP, Soman V, Sherwin RS: The influence of acute physiological increments of cortisol on fuel metabolism and insulin binding on monocytes in normal humans, J Clin Endocrinol Metab 1980:50:495-501.
19. Elia M, Carter A, Bacon S, Winearls CG, Smith R: Clinical usefulness of urinary 3-methylhis-tidine excretion in indicating muscle protein breakdown, Br Med J 1981;282:351-354.
20. Defeo PP, Horber FF, Haymond MW: Meal stimulation of albumin synthesis: A significant contributor to whole body protein synthesis in humans, Am J Physiol 1992:263:E794-E799.
21. F'rvburg DA, Gelfand RA, Barrett EJ: Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans, Am J Physiol 1991;260:E499-E504.
22. Defeo PP, Perriello G, Santeusanio F, Brunetti P, Haymond MW: Differential effects of insulin-induced hypoglycemia on the plasma branched-chain amino acid concentrations in humans, Diabetes Metab 1992; 18:277-282.
23. Kahn SF., Horber FF, Prigeon RL, Haymond MW, Porte D: Effect of corticosteroid and growth hormone on proinsulin levels in normal humans, Diabetes 1993,42:1082-1085.
24. Daughaday W: Regulation of skeletal growth by sulfation factor, Adv Intern Med 1971:17: 237-263.
25. Mauras N, Horber FF, Haymond MW: Low dose recombinant human insulin-like growth factor I fails to affect protein anabolism but inhibits islet cell secretion in humans, J Clin Endocrinol Metab 1992:75:1192-1197.
26. Tonshoff B, Ilaffncr D, Mehls O, Dietz M, Ruder H, Blum WF, Heinrich U, Stover B, Members of the German Study Group for Growth Hormone Treatment in Children with Renal Allografts: Efficacy and safely growth hormone treatment in short children with renal allografts: Three-year experience, Kidney Int 1993:44:199-207.
27. Rees L, Rigden SPA, Ward G, Prcece MA: Treatment of short stature in real disease with recombinant human growth hormone, Arch Dis Child 1990:65:856-860.
28. Allen DB, Julius JR, Breen TJ, Attie KM: Reversal of glucocorticoid-induced growth failure by human growth hormone (hGH), Pediatr Res 1996:39:84A.