Bone marrow transplantation for the treatment of haematological disorders in Down's syndrome: Toxicity and outcome

Bone Marrow Transplantation

Volumn 18, Issue 3, 1996, Pages 533-540

  Rubin, C M ^a,d   Mick, R ^b,c   Johnson, F L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Aplastic anemia; Bone marrow transplantation; Down's syndrome

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; METHOTREXATE; METHYLPREDNISOLONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AIRWAY OBSTRUCTION; ALLOGENIC BONE MARROW TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BLOOD DISEASE; BONE MARROW TRANSPLANTATION; CANDIDA ALBICANS; CHILD; CLINICAL ARTICLE; DEATH; DOWN SYNDROME; DRUG TOLERABILITY; FEMALE; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; INTENSIVE CARE; LARYNGITIS; LIFE TABLE; LUNG DISEASE; LUNG HEMORRHAGE; MALE; MUCOSA INFLAMMATION; PNEUMONIA; PRIORITY JOURNAL; RISK; SIBLING; SURVIVAL; TOXICITY; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; TRANSPLANTATION CONDITIONING; TREATMENT OUTCOME;

EID: 0029820354     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Krivit W, Good RA. Simultaneous occurrence of mongolism and leukaemia: report of a nationwide survey. Am J Dis Child 1957; 94: 289-293.
2. Miller RW. Neoplasia and Down's syndrome. Ann NY Acad Sci 1970; 171: 637-644.
3. Scholl T, Stein Z, Hansen H. Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976. Dev Med Child Neurol 1982; 24: 817-829.
4. Robison LL, Nesbit ME, Sather HN et al. Down syndrome and acute leukemia in children: a 10-year retrospective survey from Childrens Cancer Study Group. J Pediatr 1984, 105: 235-242.
5. Levitt GA, Stiller CA, Chessells JM. Prognosis of Down's syndrome with acute leukemia. Arch Dis Child 1990; 65: 212-216.
6. Ragab AH, Abdel-Mageed A, Shuster JJ et al. Clinical characteristics and treatment outcome of children with acute lymphoblastic leukemia and Down's syndrome: a Pediatric Oncology Group study. Cancer 1991; 67: 1057-1063.
7. Ravindranath Y, Abella E, Krischer JP et al. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience of Pediatric Oncology Group AML Study 8498. Blood 1992; 80: 2210-2214.
8. Woods WG, Kobrinsky N, Buckley J et al. Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia or myelodysplastic syndrome: a Childrens Cancer Group pilot study. J Clin Oncol 1993; 11: 1448-1457.
9. Lange BJ, Smith FO, Kobrinsky N et al. Therapy of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in children with Down syndrome. Proc Am Soc Clin Oncol 1996; 15: 368 (Abstr.).
10. Chiricolo M, Musa AR, Monti D et al. Enhanced DNA repair in lymphocytes of Down syndrome patients: the influence of zinc nutritional supplementation. Mutation Res 1993; 295: 105-111.
11. Kalwinsky DK, Raimondi SC, Bunin NJ et al. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. Am J Med Genet 1990; 7 (Suppl.): 267-271.
12. Atra A, Richards SM, Chessells JM. Remission death in acute lymphoblastic leukaemia: a changing pattern. Arch Dis Child 1993; 69: 550-554.
13. Blatt J, Albo V, Prin W et al. Excessive chemotherapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukemia. Lancet 1986; 2: 914.
14. Peeters MA, Poon A. Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur J Pediatr 1987; 146: 416-422.
15. Garre ML, Relling MV, Kalwinsky D et al. Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia. J Pediatr 1987; 111: 606-612.
16. Ueland PM, Refsum H, Christensen B. Methotrexate sensitivity in Down's syndrome: a hypothesis. Cancer Chemother Pharmacol 1990; 25: 384-386.
17. Rubin CM, O'Leary M, Koch PA, Nesbit ME. Bone marrow transplantation for children with acute leukemia and Down syndrome. Pediatr 1986; 78: 688-691.
18. Arenson EB, Forde MD. Bone marrow transplantation for acute leukemia and Down syndrome: report of a successful case and results of a national survey. Pediatr 1989; 114: 69-72.
19. Goleta-Dy A, Dalla Pozza L, Shaw PJ, Stevens MM. Acute myeloid leukaemia in patients with trisomy 21 (Down syndrome) treated by bone marrow transplantation. J Paediatr Child Health 1994; 30: 275-277.
20. Conter V, D'Angelo P, Rizzari C et al. High dose ara-C and F-TBI as allogeneic BMT preparative regimen for children with ALL and Down syndrome. Bone Marrow Transplant 1996; 17: 287-289.
21. Kojima S, Kato K, Matsuyama T et al. Favorable treatment outcome in children with acute myeloid leukemia and Down syndrome. Blood 1993; 81: 3164-3165.