Alcoholic liver disease

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue SUPPL. B, 1996, Pages 27-31

  Fernandez Checa J C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUTATHIONE;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; CONFERENCE PAPER; HUMAN; LIVER CIRRHOSIS; OXIDATIVE STRESS; PHOSPHORYLATION;

ALCOHOLIC INTOXICATION; ANIMALS; ETHANOL; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MICROSOMES, LIVER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029819349     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (25)

1. Derr, R.F., Porta, E.A., Larken, E.C., Rao, G.A. Is ethanol per se hepatotoxic? J Hepatol 1990, 10: 382-6.
2. Mitchell, M.C., Herlong, H.P. Alcohol and nutrition: Caloric value bioenergetics and relationship to liver damage. Ann Rev Nutr 1986, 6: 457-74.
3. Achord, J.L. Malnutrition and the role of nutrition support in alcoholic liver disease, Amer J Gastroenterol 1988, 83: 244-8.
4. Rao, G.A., Larken, E.C., Darr, R.F. Biologic effects of chronic ethanol consumption related to a different intake of carbohydrate. Alcohol 1986, 21: 369-73.
5. Mezey, E., Kalman, C.J., Diehl, A.M. Alcohol and dietary intake in the development of chronic pancreatitis and liver disease in alcoholism. Amer J Clin Nutr 1988, 48: 148-51.
6. Ashak, K.G., Zimmerman, H.J., Ray, M.B. Alcoholic liver disease: Pathologic, pathogenic and clinical aspects. Alcohol Clin Exp Res 1991, 15: 45-66.
7. Kaplowitz, N., Fernández-Checa, J.C., Ookhtens, M. In: Glutathione, Alcohol and Hepatotoxicity in Nutrition and the Origins of Disease. Halsted, C.H., Rucker, R.B. (Eds.). Academic Press: San Diego 1989, 267-81.
8. Fernández-Checa, J.C., Lu, S., Ookhtens, M., DeLeve, L. et al. Regulation of hepatic GSH. In: Hepatic Anion Transport and Bile Secretion: Physiology and Pathophysiology. Tavoloni, N., Berk, P. (Eds.). Raven Press: New York 1993, 345-95.
9. Meister, A., Anderson, M. Glutathione. Ann Rev Biochem 1983, 52: 711-60.
10. Kaplowitz, N., Aw, T.Y., Ookhtens, M. The regulation of hepatic glutathione. Ann Rev Pharmacol Toxicol 1985, 25: 715-44.
11. Fernández-Checa, J.C., Ookhtens, M., Kaplowitz, N. Effect of chronic ethanol feeding on rat hepatocytic glutathione: Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest 1989, 83: 1247-52.
12. Fernández-Checa, J.C., García-Ruiz, C., Ookhtens, M., Kaplowitz, N. Impaired uptake of GSH by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest 1991, 87: 397-405.
13. Takeshi, H., Kaplowitz, N., Kamimura, T., Tsukamoto, H., Fernández-Checa, J.C. Hepatic mitochondrial GSH depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992, 16: 1423-28.
14. García-Ruiz, C., Morales, A., Ballesta, A., Rodés, J., Kaplowitz, N., Fernández-Checa, J.C. Effect of ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest 1994, 94: 193-201.
15. Bosron, W.F., Ehrig, T., Li, T.K. Genetic factors in alcohol metabolism and alcoholism. Sem Liver Dis 1993, 13: 126-35.
16. Lieber, C.S. Hepatic metabolic and toxic effect of ethanol: 1991 update. Alcohol Clin Exp Res 1991, 15: 573-92.
17. Cronholm, T., Norsten-Hoog, C., Ekstrom, G., Handler, J.A., Thurman, R.G., Ingelman-Sundberg, M. Oxidoreduction of butanol in deermice lacking hepatic cytosolic alcohol dehydrogenase. Eur J Biochem 1992, 204: 353-7.
18. Lieber, C.S. Microsomal ethanol oxidizing system. Enzyme 1987, 37: 45-56.
19. Laposata, E., Lange, L.G. Presence of nan-oxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 1986, 231: 497-9.
20. Cederbaum, A.I., Lieber, C.S., Beattie, D.S., Rubin, E. Effects of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria. J Biol Chem 1975, 250: 5122-9.
21. Sen, R., Baltimore, D. Multiple nuclear factors interact with immunoglobulin enhancer sequences. Cell 1986, 46: 705-16.
22. Meyer, M., Schreck, R., Bauerle, P. Hydrogen peroxide and antioxidants have opposite effects on activation of NF-nB and AP-I in intact cells: AP-I as secondary antioxidant responsive factor. EMBO J 1993, 12: 2005-11.
23. Staal, F.J.T., Roederer, M., Herzenberg, L.A. Intracellular thiols regulate activation of nuclear factor NF-nB and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 1990, 87: 9943-7.
24. Shiratori, Y., Kawase, T., Shiina, S. et al. Modulation of hepatotoxicity by macrophages in the liver. Hepatology 1988, 8: 815-21.
25. Hansen, J., Cherwitz, D.L., Allen, J.I. The role of tumor necrosis factor-α in acute endotoxin induced hepatotoxicity in ethanol-fed rats. Hepatology 1994, 20: 461-74.