Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-β-trypsin complex

Biochemical Journal

Volumn 316, Issue 3, 1996, Pages 777-786

  Sreedharan, Suneal K ^a   Verma, Chandra ^b   Caves, Leo S D ^b   Brocklehurst, Simon M ^c   Gharbia, Saheer E ^d   Shah, Haroun N ^d   Brocklehurst, Keith ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBENZAMIDINE; BENZAMIDINE; CLOSTRIPAIN; CYSTEINE PROTEINASE INHIBITOR; GUANIDINE; HYDROXYL GROUP; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; SERINE; TRYPSIN;

ARTICLE; COMPETITIVE INHIBITION; COMPUTER MODEL; CONTROLLED STUDY; ELECTRIC POTENTIAL; ENZYME INHIBITOR COMPLEX; HYDROLYSIS; KINETICS; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CATALYSIS; CATTLE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; KINETICS; LEUCINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN; TRYPSIN INHIBITORS;

CLOSTRIDIUM HISTOLYTICUM;

EID: 0029819049     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3160777     Document Type: Article

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