Pharmacokinetic and α1-adrenoceptor antagonistic properties of two cyanine-type inhibitors of extraneuronal monoamine transport

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 354, Issue 3, 1996, Pages 268-274

  Russ, H ^a   Friedgen, B ^b   Konigs B ^c   Schumacher, C ^c   Graefe, K H ^b   Schomig E ^d  

^a Neurologische Psychiat Univ Klin   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

1 Adrenoceptor; Decynium22; Disprocynium24; Extraneuronal monoamine transporter; Pharmacokinetics

Indexed keywords

1,1' DIETHYL 2,2' CYANINE; 1,1' DIISOPROPYL 2,4' CYANINE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR; DECYNIUM 22; DISPROCYNIUM 24; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; HEART MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MONOAMINERGIC SYSTEM; NONHUMAN; RABBIT; RAT; VASOCONSTRICTION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; MALE; MYOCARDIUM; NOREPINEPHRINE; PHENETHYLAMINES; QUINOLINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; TETRALONES;

EID: 0029818983     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 14:48-58
2. Baker SP, Potter LT (1980) Cardiac β-adrenoceptors during normal growth of male and female rats. Br J Pharmacol 68:65-70
3. Benet LZ, Galeazzi RL (1979) Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci 68:1071-1074
4. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
5. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR, Trendelenburg U (1994) IV. International union of pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46:121-136
6. Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration which causes 50% inhibition of an enzymatic reaction. Biochem Phannacol 22:403-411
7. Daly CJ, McGrath JC, Wilson VG (1988) An examination of the post-junctional α-adrenoceptor subtypes Tor (-)-noradrenaline in several isolated blood vessels from the rabbit. Br J Pharmacol 95:473-484
8. Docherty JR, Starke K (1981) Postsynaptic α-adrenoceptor subtypes in rabbit blood vessels and rat anococcygeus muscle studied in vitro. J Cardiovasc Pharmacol 3:854-866
9. 2-adrenoceptors. Naunyn-Schmiedeberg's Arch Phannacol 317:5-7
10. Eisenhofer G (1994) Plasma normetanephrine for examination of extraneuronal uptake and metabolism of noradrenaline in rats. Naunyn-Schmiedeberg's Arch Pharmacol 349:259-269
11. Eisenhofer G, Goldstein DS, Kopin IJ (1989) Plasma dihydroxyphenylglycol for estimation of noradrenaline neuronal re-uptake in the sympathetic nervous system in vivo. Clin Sci 76:171-182
12. 1-adrenoceptors. Eur J Pharmacol 73:221-224
13. 1 and catechol-O-methyltransferase in removal of circulating catecholamines in the rabbit. Am J Physiol 267 (Endocrinol Metab 30): F814-F821
14. Friedgen B, Wölfel R, Russ H, Schömig E. Gracfe K-H (1996) The role of extraneuronal amine transport systems for the removal of extracellular catecholamines in the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 354:275-286
15. Furchgott RF, Bhadrakom S (1953) Reactions of strips of rabbit aorta to epinephrine, isoproterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther 108:129-143
16. 1-adrenoceptors. Naunyn-Schmiedeberg's Arch Pharmacol 318:1-9
17. 1-adrenoceptors with extremely high affinity. Naunyn-Schmiedeberg's Arch Pharmacol 321:7-10
18. Halbrügge T, Lütsch K, Thyen A, Graefe K-H (1991) Role of nitric oxide formation in the regulation of hemodynamics and the release of noradrenaline and adrenaline. Naunyn-Schmiedeberg's Arch Pharmacol 344:720-727
19. Iversen LL (1967) The uptake and storage of noradrenaline in sympathetic nerves. Cambridge University Press, Cambridge UK
20. Königs B, Schumacher C, Russ H, Schömig H, Sigmund M, Kammermacher H, Hanrath P (1996) Determination of α- and β-adrenoceptor-affinities to the highly potent extraneuronal eatecholamine uptake-2 inhibitors decynium22 and disprocynium24. Naunyn-Schmiedeberg's Arch Pharmacol 353 [Suppl]: R87
21. 2 and affinity constants for pharmacological competitive antagonists he estimated? J Pharm Pharmacol 30:312-313
22. 1-adrenoceptor subtypes in rat heat. Br J Pharmacol 111:533-538
23. 1-adrenoceptor subtypes. Naunyn-Schmiedeberg's Arch Pharmacol 352: 1-10
24. 1-Adrenergic receptor subtypes, inositol phosphates and sources of cell calcium. Pharmacol Rev 40: 87-119
25. 1adrenoceptor density in rats chronically treated with propranolol. Eur J Pharmacol 112:249-252
26. 1-adrenoceptor subtypes involved in noradrenaline contraction of the rabbit thoracic aorta. Br J Pharmacol 101:662-666
27. 1-adrenoceptors involved in noradrenaline-induced contraction of rat thoracic aorta and dog carotid artery. Jpn J Pharmacol 57:535-544
28. Russ H, Engel W, Schömig E (1993a) Isocyanines and pseudoisocyanines as a novel class of potent noradrenaline transport inhibitors: Synthesis, detection, and biological activity. J Med Chem 36: 4208-4214
29. Russ H, Sonna J, Keppler K, Baunach S, Schömig E (1993b) Cyanine-related compounds: a novel class of potent inhibitors of extraneuronal noradrenaline transport. Naunyn-Schmiedeberg's Arch Pharmacol 348:458-465
30. Sasso EH, O'Connor DT (1982) Prazosin depression of haroreflex function in hypertensive man. Eur J Clin Pharmacol 22:7-14
31. Schömig E (1994) Extraneuronal transport of noradrenaline. J Anton Pharmacol 14:9-10
32. 2). Naunyn-Schmiedeberg's Arch Pharmacol 345: 437-443
33. Segel IH (1975) Enzyme kinetics: behaviour and analysis of rapid equilibrium and steady state enzyme systems. John Wiley. New York London Sidney Toronto
34. Trendelenburg U (1988) The extraneuronal uptake and metabolism of catecholarnines. In: Trendelenburg U, Weiner N (eds) Handb Exp Pharmacol 90/1:279-319
35. Wilkinson L (1989) SYSTAT: the system for statistics. SYSTAT Inc., Evanston, III., USA