Vasodilator effect and tolerance induced by the nitrocompound SIN-1 in rabbit femoral artery

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue 6, 1996, Pages 387-395

  Govantes, Carlos ^a   Rodríguez Martínez, M Angeles ^a   Marín, Jesús ^a,b  

^a UNIVERSITY OF MADRID   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

endothelium; nitric oxide; nitrovasodilators; SIN 1

Indexed keywords

FREE RADICAL; GLYCERYL TRINITRATE; HYDROXYL RADICAL; LINSIDOMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SUPEROXIDE;

ANIMAL TISSUE; ARTICLE; ENDOTHELIUM; ENZYME INHIBITION; FEMORAL ARTERY; IN VIVO STUDY; MUSCLE RELAXATION; NONHUMAN; RABBIT; VASODILATATION;

ACETYLCHOLINE; ANIMALS; DRUG TOLERANCE; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMORAL ARTERY; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MOLSIDOMINE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGLYCERIN; NITROPRUSSIDE; RABBITS; SUPEROXIDES; VASODILATOR AGENTS;

EID: 0029818768     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Pohl, U., Busse, R. Endothelium-derived relaxant factor inhibits effects of nitrocompounds in isolated arteries. Amer J Physiol 1987, 252: H307-13.
2. Busse, R., Pohl, U., Mülsch, A., Bassenge, E. Modulation of the vasodilator action of SIN-1 by the endothelium. J Cardiovasc Pharmacol 1989, 14 (Suppl. 11): S81-5.
3. Flavahan, N.A., Vanhoutte, P.M. Mechanisms underlying the inhibitory interaction between the nitrovasodilator SIN-1 and the endothelium. J Cardiovasc Pharmacol 1989, 14 (Suppl. 11): S86-90.
4. Lüscher, T., Richard, V., Yang, Z. Interaction between endothelium-derived nitric oxide and SIN-1 in human and porcine blood vessels. J Cardiovasc Pharmacol 1989,14 (Suppl. 11): S76-80.
5. Mügge, A., López, J.A.G., Piegors, J., Breese, K.R., Heistad, D.D. Acetylcholine-induced vasodilatation in rabbit hind limb in vivo is not inhibited by analogues of L-arginine. Amer J Physiol 1991, 260: H242-7.
6. Moncada, S., Palmer, R.M.J., Higgs, E.A. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991, 43: 109-42.
7. Schultz, K.D., Schrör, K. Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rat ductus deferens. Nature 1977, 265: 750-1.
8. Murad, F., Mittal, C.K., Arnold, W.P., Katsuki, S., Kimura, H. Guanylate cyclase: Activation by azide, nitrocompounds, nitric oxide and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotide Res 1978, 9: 145-58.
9. Ignarro, L.J., Lippton, H., Edwards, J.C. el al.Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981, 218: 739-49.
10. Furchgott, R.F. Role of endothlium in responses of vascular smooth muscle. Circ Res 1983, 53: 557-72.
11. Feelisch, M. The biochemical pathways of nitric oxide formation from nitrovasodilators: Appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol 1991. 17(Suppl. 3): S25-33.
12. Mordvintcev, P., Mülsch, A., Busse, R., Vanin, A. On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy. Anal Biochem 1991, 199: 142-46.
13. Needleman, P., Johnson, E. Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 1973, 184: 709-15.
14. Bennet, B.M., Leitman, D.C., Schröder, H., Kawamoto, J.H., Nakatsu, K., Murad, F. Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines. J Pharmacol Exp Ther 1989, 250: 316-23.
15. Servent D., Delaforge, M., Ducrocq, C., Mansuy, D., Lenfant, M. Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P-450. Biochem Biophys Res Commun 1989, 163: 1210-6.
16. Kojda, G., Beck, J.C., Meyer, W., Noack, E. Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: Dependence on intact endothelium. Brit J Pharmacol 1994, 112: 533-40.
17. Kowaluk, E.A., Seth, P., Fung, H. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther 1992, 262: 916-22.
18. Zimrin, D.,Reichek, N., Bogin, T.T.et al. Antianginal effects of intravenous nitroglycerin over 24 hours. Circulation 1988, 77: 1376-84.
19. Bult, H., De Meyer, G.R.Y., Jordaens, F.H., Herman, A.G. Chronic exposure to exogenous nitric oxide may suppress its endogenous release and efficacy. J Cardiovasc Pharmacol 1991, 17(Suppl. 3): S79-82.
20. Münzel, T., Sayegh, H., Freeman, B.A., Tarpey, M.M., Harrison, D.G. Evidence for enhanced vascular Superoxide anion production in nitrate tolerance. A novel mechanism underlving tolerance and cross-tolerance. J Clin Invest 1995, 95: 187-94.
21. Nielsen, K.C., Owman, C. Contractile responses and amine receptor mechanism in isolated middle cerebral artery of the cat. Brain Res 1971, 27: 33-42.
22. Rodínguez-Mañas, L., Arribas, S., Sánchez-Ferrer, C.F., Marín, J. Interference of glycosylated hemoglobin with endothelium-dependent responses. Circulation 1993, 88: 2111-6.
23. Martin, W., Villani, G.M., Jothianandan, D., Furchgott, R.F. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther 1985. 232: 708-16.
24. Garland, C.G., McPherson, G.A. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Brit J Pharmacol 1992. 105: 429-35.
25. Marín, J., Sánchez-Ferrer C.F. Role of endothelium-formed nitric oxide on vascular responses. Gen Pharmacol 1990, 21: 575-87.
26. Van de Voorde, J., Clayes, M., Leusen, I. Relaxations to endothelium-derived relaxing factor and the metabolite of molsidomine, SIN-1, in the aorta and the hindquarters of the rat. J Cardiovasc Pharmacol 1989, 14 (Suppl. II): S55-61.
27. Ignarro, L.J. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 1989, 65: 1-21.
28. Van de Voorde, J., Clayes, M., Eechaute, W., Leusen, I. Parallelisms and differences in the effects of endothelium-derived relaxing factor, nitrovasodilators, and SIN-1 on rat aorta. J Cardiovasc Pharmacol 1991, 17 (Suppl. 3): S145-51.
29. Feelisch, M., Ostrowski, J., Noack, E. On the mechanism of NO release from sydnonimines. J Cardiovasc Pharmacol 1989, 14 (Suppl. II): S13-22.
30. Komori, K., Lorenz, R.R., Vanhoutte, P.M. Nitric oxide, ACh, and electrical and mechanical properties of canine arterial smooth muscle. Amer J Physiol 1988, 255: H207-12.
31. Miller, V.M., Vanhoutte, P.M. Relaxations to SIN-1. nitric oxide, and sodium nitroprusside in canine arteries and veins. J Cardiovasc Pharmacol 1989, 14 (Suppl. II): S67-71.
32. Henry, P.J., Horowitz, J.D., Louis, W.J. Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade. J Pharmacol Exp Ther 1988, 248: 762-68.
33. Kuhn, M., Förstermann, U. Endothelium-dependent vasodilatation in human epicardial coronary arteries: Effect of prolonged exposure to glyceryl trinitrate or SIN-1. J Cardiovasc Pharmacol 1989, 14 (Suppl. II): S47-54.
34. Förster, S., Woditsch, I., Schröder, H., Schrör, K. Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation. J Cardiovasc Pharmacol 1991, 17: 867-72.
35. Berkenboom, G., Fontaine, J., Degre, S. Persistence of the response to SIN-1 on isolated coronary arteries rendered tolerant to nitroglycerin in vitro or in vivo. J Cardiovasc Pharmacol 1988, 12: 345-49.
36. Kukovetz., W.R., Holzmann, S. Tolerance and cross-tolerance between SIN-1 and nitric oxide in bovine coronary arteries, J Cardiovasc Pharmacol 1989, 14 (Suppl. II): S40-6.