Effects of two injectable anesthetic agents on coagulation assays in the rat

Laboratory Animal Science

Volumn 46, Issue 4, 1996, Pages 430-433

  Stringer, Steven K ^a   Seligmann, Bruce E ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; KETAMINE; URETHAN; XYLAZINE;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; DRUG EFFECT; HEMATOLOGICAL PARAMETERS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RAT; THROMBIN TIME;

ANESTHESIA; ANESTHETICS; ANIMALS; BLOOD COAGULATION; INJECTIONS, INTRAPERITONEAL; KETAMINE; MALE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RATS; RATS, SPRAGUE-DAWLEY; THROMBIN TIME; URETHANE; XYLAZINE;

EID: 0029818029     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Gill, T. J., III, G. J. Smith, R. W. Wissler, et al. 1989. The rat as an experimental animal. Science 245:269-276.
2. Hauptmann, J., and F. Markwardt. 1992. Pharmacologic aspects of the development of synthetic thrombin inhibitors as anticoagulants. Semin. Thromb. Haemostas. 18:200-217.
3. Dailey, J. F. 1991. Dailey's notes on blood. Medical Consulting Group, Somerville, Mass.
4. Hauptmann, J., and B. Kaiser. 1993. Anticoagulant and antithrombotic action of the factor Xa inhibitor antistasin (ATS). Thromb. Res. 71:169-174.
5. Doutremepuich, C., E. Daharo, M. Guyot, et al. 1989. Antithrombotic activity of recombinant hirudin in the rat: a comparative study with heparin. Thromb. Res. 54:435-445.
6. Hauptmann, J., B. Kaiser, G. Nowak, et al. 1990. Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and factor Xa inhibitors. Thromb. Haemostas. 63:220-223.
7. Markwardt, F., B. Kaiser, and G. Nowak. 1989. Studies of antithrombotic effects of recombinant hirudin. Thromb. Res. 54:377-388.
8. Vogel, G. M. T., D. G. Meulaman, F. G. M. Bourgondien, et al. 1989. Comparison of two experimental thrombosis models in rats: effects of four glycosaminoglycans. Thromb. Res. 54:399-410.
9. Markwardt, F., J. Hauptmann, G. Nowak, et al. 1982. Pharmacological studies on the antithrombotic action of hirudin in experimental animals. Thromb. Haemostas. 47:226-229.
10. Freund, M., J-P. Cazenave, M. Courtney, et al. 1990. Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation (DIC) induced by tissue factor in rats. Thromb. Haemostas. 63:187-192.
11. Balasubramanian, N., D. R. St. Laurent, M. A. Federici, et al. 1993. Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs: an examination of the role of the amino group in the D-Phe-Pro-Arg-H series. J. Med. Chem. 36:300-303.
12. Schumacher, W. H., C. H. Heran, T. E. Steinbacher, et al. 1992. Thrombin inhibition compared with other antithrombotic drugs in rats. Thromb. Res. 68:157-166.
13. Schumacher, W. H., T. E. Steinbacher, C. H. Heran, et al. 1993. Effects of antithrombotic drugs in a rat model of aspirininsensitive arterial thrombosis. Thromb. Haemostas. 69:509-514.
14. Markwardt, F., G. Nowak, and J. Hoffman. 1977. The influence of drugs on disseminated intravascular coagulation (DIC). II. Effects of naturally occurring and synthetic hirudin inhibitors. Thromb. Res. 11:275-283.
15. Freund, M., F. Mantz, P. Nicolini, et al. 1993. Experimental thrombosis on a collagen coated arterioarterial shunt in rats: a pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition. Thromb. Haemostas. 69:515-521.
16. Leonard, R., and Z. Ruben. 1986. Hematology reference values for peripheral blood of laboratory rats. Lab. Anim. Sci. 36:277-281.
17. Seaman, A. J., and M. R. Malinou. 1968. Blood clotting in nonhuman primates. Lab. Anim. Sci. 18:80-84.
18. Smith, L. J., K. L. Schaible, R. G. Fessler, et al. 1987. Examination of the utility of the rat as an animal model for human anticoagulation. Haemostasis 17:206-210.
19. Scheving, L. E., and J. E. Pauly. 1967. Daily rhythmic variations in blood coagulation times in rats. Anat. Rec. 157:657-666.
20. Dejana, E., S. Villa, and G. de Gaetans. 1982. Bleed time in rats: a comparison of different experimental conditions. Thromb. Haemostas. 48:108-111.
21. Wixson, S. K., W. J. White, H. C. Hughes, Jr., et al. 1987. A comparison of pentobarbital, fentanyl-droperidol, ketaminexylazine, and ketamine-diazepam anesthesia in adult male rats. Lab. Anim. Sci. 37:726-730.
22. Wixson, S. K., W. J. White, H. C. Hughes, Jr., et al. 1987. The effects of pentobarbital, fentanyl-droperidol, ketaminexylazine, and ketamine-diazepam anesthesia on noxious stimulus perception in adult male rats. Lab. Anim. Sci. 37:731-735.
23. Smith, W. 1993. Responses of laboratory animals to some injectable anesthetics. Lab. Animals 27:30-39.
24. Whelan, G., and P. A. Flecknell. 1992. The assessment of depth of anesthesia in animals and man. Lab. Animals 26:153-162.
25. Conybeare, G., G. B. Leslie, K. Angles, et al. 1988. An improved simple technique for the collection of blood samples from rats and mice. Lab. Animals 22:177-182.
26. Omaye, S. T., J. H. Skala, M. D. Gretz, et al. 1987. Simple method for bleeding the unanesthetized rat by tail venipuncture. Lab. Animals 21:261-264.
27. Baxter Healthcare Corp., Dade Div. 1989. Thrombin clotting time reagent. L10299-BH-C. Miami, Fla.
28. Baxter Healthcare Corp., Dade Div. 1992. Actin FS activated PTT reagent, L1B0242-J. Miami, Fla.
29. Baxter Healthcare Corp., Dade Div. 1989. Thromboplastin IS: for use in prothrombin time determinations and prothrombin time-based assays. L108115-BH. Miami, Fla.
30. Sirridge, M. S., and R. Shannon. 1983. Laboratory evaluation of hemostasis and thrombosis. Lea & Febiger, Philadelphia.