Simian virus 40 small t antigen activates the carboxy-terminal transforming p53-binding domain of large T antigen

Journal of Virology

Volumn 70, Issue 10, 1996, Pages 6781-6789

  Zerrahn, Jens ^a,b   Tiemann, Frank ^a,c   Deppert, Wolfgang ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS LARGE T ANTIGEN; VIRUS SMALL T ANTIGEN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL TRANSFORMATION; FIBROBLAST; NONHUMAN; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SIMIAN VIRUS 40;

EID: 0029817997     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.6781-6789.1996     Document Type: Article

References (91)

1. Avantaggiati, M. L., M. Carbone, A. Graessmann, Y. Nakatani, B. Howard, and A. S. Levine. 1996. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300. EMBO J. 15:2236-2248.
2. Bargonetti, J., P. N. Friedman, S. E. Kern, B. Vogelstein, and C. Prives. 1991. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65:1083-1091.
3. Bargonetti, J., I. Reynisdottir, P. N. Friedman, and C. Prives. 1992. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev. 6:1886-1898.
4. Benjamin, T., and P. K. Vogt. 1990. Cell transformation by viruses, p. 317-367. In B. N. Fields and D. M. Knipe (ed.). Virology, vol. 1. Raven Press, New York.
5. Bikel, I., and M. R. Loeken. 1992. Involvement of simian virus 40 (SV40) small t antigen in transactivation of SV40 early and late promoters. J. Virol. 66:1489-1494.
6. Brinsler, R. L., H. Y. Chen, A. Messing, T. van Dyke, A. J. Levine, and R. Palmiter. 1984. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37:367-379.
7. Canman, C. E., C. Y. Chen, M. H. Lee, and M. B. Kastan. 1994. DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. Cold Spring Harbor Symp. Quant. Biol. 59:277-286.
8. Chang, L.-S., M. Pater, N. Hutchinson, and G. Di Mayorca. 1984. Transformation by purified early genes of simian virus 40. Virology 133:341-353.
9. Cobrinik, D. 1995. Regulatory interactions among E2Fs and cell cycle control proteins. Curr. Top. Microbiol. Immunol. 208:31-61.
10. Cox, L. S., and D. A. Lane. 1995. Tumour suppressors, kinase and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 17:501-508.
11. DeCaprio, J. A., J. W. Ludlow, J. Figge, J.-Y. Shew, C.-M. Huang, W.-H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of retinoblastoma susceptibility gene. Cell 54:275-283.
12. Deppert, W. 1989. P53: Onco- or anti-onco-gene? A critical review. NATO Adv. Study Inst. Ser. A Life Sci. H34:398-407.
13. Deppert, W. 1994. The yin and yang of p53 in cellular proliferation. Cancer Biol. 5:187-202.
14. Deppert, W., and M. Haug. 1986. Evidence for free and metabolically stable p53 protein in nuclear subfractions of simian virus 40-transformed cells. Mol. Cell. Biol. 6:2233-2240.
15. Deppert, W., M. Haug, and T. Steinmayer. 1987. Modulation of p53 protein expression during cellular transformation with simian virus 40. Mol. Cell. Biol. 7:4453-4463.
16. Deppert, W., T. Steinmayer, and W. Richter. 1989. Cooperation of SV40 large T antigen and the cellular protein p53 in maintenance of transformation. Oncogene 4:1103-1110.
17. Dittmer, D., S. Pati, G. Zambetti, S. Chu, A. K. Teresky, M. Moore, C. Finlay, and A. J. Levine. 1993. Gain of function mutations in p53. Nature Genet. 4:42-46.
18. Dobbelstein, M., A. K. Arthur, S. Dehde, K. van Zee, A. Dickmann, and E. Fanning. 1992. Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene 7:837-847.
19. Donehower, L. A., and A. Bradley. 1993. The tumor suppressor p53. Biochim. Biophys. Acta 1155:181-205.
20. Dyson, N., K. Buchkovich, P. Whyte, and E. Harlow. 1989. The cellular 107k protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58:249-255.
21. Eckhart, W., and R. A. Weinberg (ed.). 1989. Oncogenes and the molecular origins of cancer, p. 223-238. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
22. Rb and a second cellular protein, p120. Cell 58:257-267.
23. Fanning, E. 1992. Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J. Virol. 66:1289-1293.
24. Farmer, G., J. Bargonetti, H. Zhu, P. Friedman, R. Prywes, and C. Prives. 1992. Wild-type p53 activates transcription in vitro. Nature (London) 358: 83-86.
25. Feunteun, J., M. Kress, M. Gardes, and R. Monier. 1978. Viable deletion mutants in the simian virus 40 early region. Proc. Natl. Acad. Sci. USA 75:4455-4459.
26. Freeman, A. E., H. J. Igel, and P. J. Price. 1975. Carcinogenesis in vitro. I. In vitro transformation of rat embryo cells: correlations with the known tumorigenic activity of chemicals in rodents. In Vitro 2:107-116.
27. Green, M. R. 1989. When the products of oncogenes and anti-oncogenes meet. Cell 56:1-3.
28. Gurney, E. G., S. Tamowski, and W. Deppert. 1986. Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen. J. Virol. 57:1168-1172.
29. Hainaut, P. 1995. The tumor suppressor protein p53: a receptor to genotoxic stress that controls cell growth and survival. Curr. Opin. Oncol. 7:76-82.
30. Halevy, O., D. Michalovitz, and M. Oren. 1990. Different tumor-derived p53 mutants exhibit distinct biological activities. Science 250:113-116.
31. Hansen, R., R. Reddel, and A. Braithwaite. 1995. The transforming oncogenes determine the mechanism by which p53 suppresses cell transformation: pRb-mediated growth arrest or apoptosis. Oncogene 11:2535-2545.
32. Harlow, E., L. V. Crawford, D. C. Pim, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39: 861-869.
33. Jat, P. S., C. L. Cepko, R. C. Mulligan, and P. A. Sharp. 1986. Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Mol. Cell. Biol. 6:1204-1217.
34. Jat, P. S., and P. A. Sharp. 1986. Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts. J. Virol. 59:746-750.
35. Jog, P., B. Joshi, V. Dhamankar, M. J. Imperiale, J. Rutila, and K. Rundell. 1990. Mutational analysis of simian virus 40 small t antigen. J. Virol. 64: 2895-2900.
36. Joshi, B., and K. Rundell. 1990. Association of simian virus 40 small t antigen with the 61-kilodalton component of a cellular protein complex. J. Virol. 64:5649-5651.
37. Kohrman, D. C., and M. J. Imperiale. 1992. Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein. J. Virol. 66:1752-1760.
38. Lane, D. P. 1992. p53, guardian of the genome. Nature (London) 358:15-16.
39. Lane, D. P., and L. V. Crawford. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature (London) 278:261-263.
40. LaThangue, N. B. 1994. DRDF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114.
41. Lee, J. M., and A. Bernstein. 1995. Apoptosis, cancer and the p53 tumor suppressor gene. Cancer Metastasis Rev. 14:149-161.
42. Levine, A. J. 1990. The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses. Virology 177:419-426.
43. Levine, A. J. 1993. The tumor suppressor genes. Annu. Rev. Biochem. 62:623-651.
44. Linzer, D. I. H., and A. J. Levine. 1979. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43-52.
45. Loeken, M. R. 1992. Simian virus 40 small t antigen trans activates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A. J. Virol. 66:2551-2555.
46. Locken, M. R., I. Bikel, D. M. Livingstone, and J. Brandy. 1988. Transactivation of RNA polymerase II and III promoters by SV40 small t antigen. Cell 55:1171-1177.
47. Long, S. B., H. Y. Ho, C. L. Chen, and M. D. Lai. 1995. Complex of simian virus large T antigen and p53 can bind DNA specifically. Anticancer Res. 15:1375-1380.
48. Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (London) 362:847-849.
49. Marshall, C. J. 1991. Tumor suppressor genes. Cell 64:313-326.
50. Michalovitz, D., O. Halevy, and M. Oren. 1991. p53 mutations: gains or losses? J. Cell. Biochem. 45:22-29.
51. Mietz, J. A., T. Unger, J. M. Huilbregtse, and P. M. Howley. 1992. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 11:5013-5020.
52. Montenarh, M., M. Kohler, G. Aggeler, and R. Henning. 1985. Structural prerequisites of simian virus 40 large T antigen for the maintenance of cell transformation. EMBO J. 4:2941-2947.
53. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
54. Pallas, D. C., L. K. Shahrik. B. L. Martin, S. Jaspers, T. B. Miller, D. L. Brautigan, and T. M. Roberts. 1990. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60:167-176.
55. Patschinsky, T., U. Knippschild, and W. Deppert. 1992. Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells. J. Virol. 66:3846-3859.
56. Peden, K. W. C., A. Srinivasan, J. M. Farber, and J. M. Pipas. 1989. Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen arc defective for binding cellular protein p53. Virology 168: 13-21.
57. Pietenpol, J. A., T. Tokino, S. Thiagalingam, W. S. El-Deiry, K. W. Kinzler, and B. Vogelstein. 1994. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl. Acad. Sci. USA 91:1998-2002.
58. Pintel, D., N. Bouck, and G. di Mayorca. 1981. Separation of lytic and transforming functions of the simian virus 40 A region: two mutants which are temperature sensitive for lytic functions have opposite effects on transformation. J. Virol. 38:518-528.
59. Pipas, J. M. 1992. Common and unique features of T antigens encoded by the polyomavirus group. J. Virol. 66:3979-3985.
60. Porcu, P., A. Ferber, Z. Pietrzkowski, C. T. Roberts, M. Adamo, D. LeRoith, and R. Baserga. 1992. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulin like growth factor 1 with its receptor. Mol. Cell. Biol. 12:5069-5077.
61. Prives, C., J. Bargonetti, P. N. Friedman, J. J. Manfredi, and E. H. Wang. 1991. Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen. Cold Spring Harbor Symp. Quant. Biol. 56:227-235.
62. Prives, C., and J. J. Manfredi. 1993. The p53 tumor suppressor protein: meeting review. Genes Dev. 7:529-534.
63. Prouty, S. M., K. D. Hanson, A. L. Boyle, M. Shichiri, M. R. Follansbee, W. Kang, and J. M. Sedivy. 1993. A cell culture model system for genetic analyses of the cell cycle by targeted homologous recombination. Oncogene 8:899-907.
64. Quartin, R. S., C. N. Cole, J. M. Pipas, and A. J. Levine. 1994. The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells. J. Virol. 68:1334-1341.
65. Risser, R., and R. Pollack. 1974. A nonselective analysis of SV40 transformation of mouse 3T3 cells. Virology 59:477-489.
66. Ruediger, R., D. Roeckel, J. Fait, A. Bergqvist, G. Magnusson, and G. Walter. 1992. Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol. Cell. Biol. 12:4872-4882.
67. r proteins with simian virus 40 small-t antigen in productively infected cells. J. Virol. 61:1240-1243.
68. Sawai, E. T., and J. S. Butel. 1989. Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells. J. Virol. 63:3961-3973.
69. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
70. Scheidtmann, K. H., and A. Haber. 1990. Simian virus 40 large T antigen induces or activates a protein kinase which phosphorylates the transformation-associated protein p53. J. Virol. 64:672-679.
71. Scheidtmann, K. H., M. C. Mumby, K. Rundell, and G. Walter. 1991. Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Mol. Cell. Biol. 11:1996-2003.
72. Segawa, K., A. Minowa, K. Sugasawa, T. Takano, and F. Hanaoka. 1993. Abrogation of p53-mediated transactivation by SV40 large T antigen. Oncogene 8:543-548.
73. Tiemann, F., and W. Deppert. 1994. Immortalization of BALB/c mouse embryo fibroblasts alters SV40 large T-antigen interactions with the tumor suppressor p53 and results in a reduced SV40 transformation-efficiency. Oncogene 9:1907-1915.
74. Tiemann, F., and W. Deppert. 1994. Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences. J. Virol. 68:2869-2878.
75. Tiemann, F., J. Zerrahn, and W. Deppert. 1995. Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation. J. Virol. 69:6115-6121.
76. Tooze, J. 1981. Molecular biology of tumor viruses, part 2. Cold Spring Harbor Laboratory: Cold Spring Harbor, N.Y.
77. Valentinis, B., P. L. Porcu, K. Quinn, and R. Baserga. 1994. The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. Oncogene 9:825-831.
78. Vogelstein, B., and K. W. Kinzler. 1992. p53 function and dysfunction. Cell 70:523-526.
79. Wang, W.-B., I. Bikel, E. Marsilio, D. Newsome, and D. M. Livingston. 1994. Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen. J. Virol. 68:6180-6187.
80. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
81. Whyte, P., H. E. Ruley, and E. Harlow. 1988. Two regions of the adenovirus early region 1A proteins are required for transformation. J. Virol. 62:257-265.
82. Whyte, P., N. M. Williamson. and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
83. Wulf, E., A. Deboben, F. A. Bautz, H. Faulstich, and T. Wieland. 1979. Fluorescent phallotoxin, a tool for the visualization of cellular actin. Proc. Natl. Acad. Sci. USA. 76:4498-4502.
84. Yaciuk. P., M. C. Carter, J. M. Pipas, and E. Moran. 1991. Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene product. Mol. Cell. Biol. 11:2116-2124.
85. Yang, S.-I., R. L. Lickteig, R. Estes, K. Rundell, G. Walter, and M. C. Mumby. 1991. Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol. Cell. Biol. 11:1988-1995.
86. Yew, P. R., and A. J. Berk. 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature (London) 357: 82-85.
87. Zerrahn, J., and W. Deppert. 1993. Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen. J. Virol. 67:1555-1563.
88. Zerrahn. J., W. Deppert, D. Weidemann, T. Patschinsky, F. Richards, and J. Milner. 1992. Correlation between the conformational phenotype of p53 and its subcellular location. Oncogene 7:1371-1381.
89. Zerrahn, J., U. Knippschild, T. Winkler, and W. Deppert. 1993. Independent expression of the transforming amino-terminal domain of SV40 large T antigen from an alternatively spliced third SV40 early mRNA. EMBO J. 12:4739-4746.
90. Zhou-Li, F., C. D'Ambrosio, S. Li, E. Surmacz, and R. Baserga. 1995. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol. 15:4232-4239.
91. Zhu, J., P. W. Rice, M. Chamberlain, and C. N. Cole. 1991. Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J. Virol. 65:2778-2790.