Electrophoretic analysis of nucleic acids isolated from scrapie-infected hamster brain

Journal of General Virology

Volumn 77, Issue 9, 1996, Pages 2371-2378

  Bountiff, Lynne ^a,b   Levantis, Petros ^a   Oxford, John ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SINGLE STRANDED DNA;

AGAR GEL ELECTROPHORESIS; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; BRAIN SPONGIOSIS; CELL FRACTIONATION; COMPARATIVE STUDY; HAMSTER; NONHUMAN; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; SCRAPIE AGENT; SHEEP DISEASE;

ANIMALIA; CRICETINAE; OVIS ARIES; SCRAPIE PRION;

EID: 0029817745     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-9-2371     Document Type: Article

References (34)

1. Adams, D. H. (1972). Studies on DNA from normal and scrapie affected mouse brain. Journal of Neurochemistry 19, 1869-1882.
2. Aitken, J. M., Williamson, J. L. & Marsh, R. F. (1989). Evidence of mitochondrial involvement in scrapie infection. Journal of Virology 63, 1686-1694.
3. Aiken, J. M., Williamson, J. L., Borchardt, L. M. & Marsh, R. F. (1990). Presence of mitochondrial D-loop DNA in scrapie infected brain preparations enriched for the prion protein. Journal of Virology 64, 3265-3268.
4. Akowitz, A., Sklaviadis, T. & Manuelidis, L. (1994). Endogenous viral complexes with long RNA cosediment with the agent of Creutzfeldt-Jakob disease. Nucleic Acids Research 22, 1101-1107.
5. Alper, T., Cramp, W. A., Haig, D. A. & Clarke, M. C. (1967). Does the agent of scrapie replicate without nucleic acid? Nature 214, 764-766.
6. Basler, K., Oesch, B., Scott, M., Westaway, D., Walchli, M., Groth, D. F., McKinley, M. P., Prusiner, S. B. & Weissman, C. (1986). Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell 46, 417-428.
7. Bessen, R. A., Kocisko, D. A., Raymond, G. J., Nandan, S., Lansbury, P. T. & Caughey, B. (1995). Non-genetic propagation of scrapie-specific prion protein. Nature 375, 698-700.
8. Borras, M. T., Kingsbury, D. T., Gadjusek, D. C. & Gibbs, C. J., Jr (1982). Inability to transmit scrapie by transfection of mouse embryo cells in vitro. Journal of General Virology 58, 263-271.
9. Bortner, C. D., Oldenburg, N. B. E. & Cidlowski, J. A. (1995). The role of DNA fragmentation in apoptosis. Trends in Cell Biology 5, 21-26.
10. Bountiff, L. (1983). Nucleic acids in scrapie. PhD thesis, Reading University, Reading, UK.
11. Bruce, M., Chree, A., McConnell, I., Foster, J., Pearson, G. & Fraser, H. (1994). Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 343, 405-411.
12. Duguid, J. R. & Dinauer, M. C. (1989). Library subtraction of in vitro cDNA libraries to identify differentially expressed genes in scrapie infection. Nucleic Acids Research 18, 2789-2792.
13. Fraser, H. & Dickinson, A. G. (1968). The sequential development of the brain lesions in three strains of mice. Journal of Comparative Pathology 78, 301-311.
14. Hallick, R. B., Chelm, B. K., Gray, P. W. & Orozco, E. M., Jr (1977). Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation. Nucleic Acids Research 4, 3055-3064.
15. Hunter, G. D., Kimberlin, R. H., Collis, S. C. & Millson, G. C. (1973). Viral and non-viral properties of the scrapie agent. Annals of Clinical Research 5, 262-267.
16. Kimberlin, R. H., Millson, G. C., Bountiff, L. & Collis, S. C. (1974a). A comparison of the biochemical changes induced in mouse brain by cuprizone toxicity and by scrapie infection. Journal of Comparative Pathology 84, 263-270.
17. Kimberlin, R. H., Shirt, D. B. & Collis, S. C. (1974b). The turnover of isotopically labelled DNA in vivo in developing, adult and scrapie affected mouse brain. Journal of Neurochemistry 23, 241-248.
18. Kimberlin, R. H. & Walker, C. A. (1977). Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34, 295-304.
19. Kimberlin, R. H. & Walker, C. A. (1979). Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. Journal of Comparative Pathology 89, 551-562.
20. Lax, A. J., Bountiff, L., Millson, G. C. & Hunter, G. D. (1982). Some new insights into the nature of the scrapie agent. In Virus Non-Conventionels et Affections Du Systeme Nerveaux Central, pp. 47-56. Edited by L. A. Court & F. Cathala. Paris: Masson.
21. McBride, P. A., Bruce, M. E. & Fraser, H. (1988). Immunostaining of scrapie cerebral amyloid plaques with antisera raised to scrapie-associated fibrils (SAF). Neuropathology and Applied Neurobiology 14, 325-336.
22. McKinley, M. P., Bolton, D. C. & Prusiner, S. B. (1983). A protease resistant protein is a structural component of the scrapie agent. Cell 35, 57-62.
23. Manuelidis, L. & Manuelidis, E. E. (1981). Search for specific DNAs in Creutzfeldt-Jakob infectious brain fractions using nick translation. Virology 109, 435-443.
24. Meyer, N., Rosenbaum, V., Schmidt, B., Gilles, K., Mirenda, C., Groth, D. F., Prusiner, S. B. & Reisner, D. (1991). Search for a putative scrapie genome in purified prion fractions reveals a paucity of nucleic acids. Journal of General Virology 72, 1-113.
25. Millson, G. C. (1965). Lysosomal enzymes in normal and scrapie mouse brain. Journal of Neurochemistry 12, 461-468.
26. Narang, H. K. (1990). Detection of single stranded DNA in scrapie infected brain by electron microscopy. Journal of Molecular Biology 216, 469-473.
27. Narang, H. K. (1991). Evidence of single stranded DNA in tubulofilamentous particles: their relationship to scrapie-associated fibrils. Intervirology 32, 185-192.
28. Narang, H. K. (1993). Molecular cloning of single stranded DNA purified from scrapie infected hamster brain. Research in Virology 144, 375-387.
29. Narang, H. K., Millar, N. S., Asher, D. M. & Gadjusek, D. C. (1991). Increased multimeric mitochondrial DNA in the brain of scrapie infected hamsters. Intervirology 32, 316-324.
30. Norberg, A. B. & Persson, H. (1984). Accumulation of heavy-metal ions by Zoogloea ramigera. Biotechnology and Bioengineering 26, 239-246.
31. Prusiner, S.B. (1995). Biochemistry and genetics of prion proteins. European Journal of Medicinal Chemistry 30, Suppl. (1s-688s), 11s-50s.
32. Rubenstein, R., Merz, P. A., Kascak, R. J., Scalici, C. L., Papini, M. C., Carp, R. I. & Kimberlin, R. H. (1991). Scrapie-infected spleens: analysis of infectivity, scrapie-associated fibrils, and protease-resistant proteins. Journal of Infectious Diseases 164, 29-35.
33. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd edn. New York: Cold Spring Harbor Laboratory.
34. Stahl, N., Baldwin, M. A., Teplow, D. B., Hood, L., Gibson, B. W., Burlinghame, A. L. & Prusiner, S. B. (1993). Structural analysis of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry 32, 1991-2002.