Endogenous Mtv-encoded superantigens are not required for development of murine AIDS

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 8148-8150

  McCarty, Thomas C ^a   Chattopadhyay, Sisir K ^a   Scherer, Mark T ^b   Fredrickson, Torgny N ^c   Hartley, Janet W ^a   Morse III, Herbert C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUPERANTIGEN; VIRUS ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; SPLEEN WEIGHT; VIRUS INFECTION;

EID: 0029817475     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.8148-8150.1996     Document Type: Article

References (32)

1. Acha-Orbea, H., A. N. Shakhov, L. Scarpellino, E. Koolb, V. A. Muller, A. Vessaz-Shaw, R. Fuchs, K. Blochlinger, P. Rollini, J. Billotte, et al. 1991. Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumour virus. Nature (London) 350:207-211.
2. Aziz, D. C., Z. Hanna, and P. Jolicoeur. 1989. Severe immunodeficiency disease induced by a defective murine leukemia virus. Nature (London) 338:505-508.
3. Chattopadhyay, S. K., H. C. Morse III, M. Makino, S. K. Ruscetti, and J. W. Hartley. 1989. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc. Natl. Acad. Sci. USA 86: 3862-3866.
4. Chattopadhyay, S. K., D. N. Sengupta, T. N. Fredrickson, H. C. Morse III, and J. W. Hartley. 1991. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice. J. Virol. 65:4232-4241.
5. Cloyd, M. W., J. W. Hartley, and W. P. Rowe. 1980. Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses. J. Exp. Med. 151:542-552.
6. Cloyd, M. W., J. W. Hartley, and W. P. Rowe. 1981. Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR X NFS crosses. J. Exp. Med. 154:450-459.
7. Doyon, L., C. Simard, R.-P. Sékaly, and P. Jolicoeur. 1996. Evidence that the murine AIDS defective virus does not encode a superantigen. J. Virol. 70:1-9.
8. Dyson, P. J., A. M. Knight, S. Fairchild, E. Simpson, and K. Tomonari. 1991. Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes. Nature (London) 349:531-532.
9. + T cells of retrovirus-induced immune-deficient mice. J. Immunol. 148:3377-3384.
10. Frankel, W. N., C. Rudy, J. M. Coffin, and B. T. Huber. 1991. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature (London) 349:526-528.
11. Gazzinelli, R. T., I. Eltoum, T. A. Wynn, and A. Sher. 1993. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151:3672-3681.
12. + T cells. J. Virol. 68:5819-5824.
13. Hartley, J. W., T. N. Fredrickson, R. A. Yetter, M. Makino, and H. C. Morse III. 1989. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J. Virol. 63:1223-1231.
14. Heise, M., K. Chow, and O. Kanagawa. 1993. Interaction between T cells and murine acquired immunodeficiency virus superantigen: effect of second signal on T cell reactivity to the MAIDS virus superantigen. Int. Immunol. 5:583-590.
15. Hügin, A. W., Y. Tang, M. S. Vacchio, R. J. Hodes, R. A. Morawetz, N. A. Giese, R. Abe, W.-K. Kim, S. K. Chattopadhyay, M. T. Scherer, M. W. Moore, T. N. Fredrickson, J. K. Amory, A. Kulkarni, J. W. Hartley, and H. C. Morse III. Is a superantigen involved in the pathogenesis of MAIDS? In K. Tominari (ed.), Viral superantigens. in press. CRC Press, Boca Raton, Fia.
16. Hügin, A. W., M. S. Vacchio, and H. C. Morse III. 1991. A virus-encoded "superantigen" in a retrovirus-induccd immunodeficiency syndrome of mice. Science 252:424-427.
17. Hugo, P., J. W. Kappler, and P. C. Marrack. 1993. Positive selection of TcRα/β thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? Immunol. Rev. 135:133-155.
18. Janeway, C. A. 1993. Are there cellular superantigens? Immunol. Rev. 131: 189-200.
19. Kanagawa, O., B. A. Nussrallah, M. E. Wiebenga, K. M. Murphy, H. C. Morse III, and F. R. Carbone. 1992. Murine AIDS superantigen reactivity of the T cells bearing Vβ5 T cell antigen receptor. J. Immunol. 149:9-16.
20. Klinman, D. M., and H. C. Morse III. 1989. Characteristics of B cell proliferation and activation in murine AIDS. J. Immunol. 142:1144-1149.
21. Makino, M., H. C. Morse III, T. N. Fredrickson, and J. W. Hartley. 1990. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome. J. Immunol. 144:4347-4355.
22. Marrack, P., E. Kushnir, and J. Kappler. 1991. A maternally inherited superantigen encoded by a mammary tumour virus. Nature (London) 349: 524-526.
23. Morawetz, R. A., T. M. Doherty, N. A. Giese, J. W. Hartley, W. Müller, R. Kühn, K. Rajewsky, R. Coffman, and H. C. Morse III. 1994. Resistance to murine acquired immunodeficiency syndrome. Science 265:264-266.
24. Morse, H. C., III, N. Giese, R. Morawetz, Y. Tang, R. Gazzinelli, W.-K. Kim, S. Chattopadhyay, and J. W. Hartley. 1995. Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice. Springer Semin. Immunopathol. 17:231-245.
25. Mosier, D. E., R. A. Yetter, and H. C. Morse III. 1985. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J. Exp. Med. 161:766-784.
26. Muralidhar, G., S. Koch, M. Haas, and S. L. Swain. 1992. CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy. J. Exp. Med. 175:1589-1599.
27. Muralidhar, G., S. Koch, and S. L. Swain. 1993. CD4 T cell subsets and superantigen in MAIDS. Adv. Biosci. 86:289-296.
28. O'Neill, H. C., and C. Jolly. 1992. Retroviral superantigen. Immunol. Today 13:462. (Letter.)
29. Scherer, M. T., L. Ignatowiez, A. Pullen, J. Kappler, and P. Marrack. 1995. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J. Exp. Med. 182:1493-1504.
30. + T cells in murine acquired immunodeficiency syndrome. J. Immunol. 152:1712-1722.
31. 1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. Proc. Natl. Acad. Sci. USA 91:3759-3763.
32. + T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS). J. Exp. Med. 168:623-635.