Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells

Chemotherapy

Volumn 42, Issue 6, 1996, Pages 459-464

  Yoshimura, Tomoaki ^a   Kurita, Chikako ^a   Usami, Eiseki ^a   Nakao, Toshiya ^a   Shino, Watanabe ^a   Kobayashi, Joji ^a   Yamazaki, Futoshi ^a   Nagai, Yamazaki ^b  

^a OGAKI MUNICIPAL HOSPITAL   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Interleukin 1 beta; ; Interleukin 2; Levofloxacin; Mononuclear cell; Tumor necrosis factor alpha;

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LEVOFLOXACIN; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0029817190     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000239480     Document Type: Article

References (15)

1. Roche Y, Fay M, Gougerot-Pocida-lo MA: Effects of quinolones on interleukin 1 production in vitro by human monocytes. Immunophar-macology 1987;13:99-109.
2. Roche Y, Fay M, Gougcrot-Pocida-lo MA: Enhancement of interleukin 2 production by quinolone-treated human mononuclear leukocytes. Int J Immunopharmacol 1988; 10:161-167.
3. Riesbeck K, Andersson J, Gullberg M, Forsgren A: Fluorinated 4-qui-nolones induce hyperproduction of interleukin 2. Proc Natl Acad Sci USA 1989;86:2809-2813.
4. Stünkel KGE, Hewlett G, Zeiler HJ: Ciprofloxacin enhances T cell function by modulating interleukin activities. Clin Exp Immunol 1991:86: 525-531.
5. Klcttcr Y, Riklis I, Shalit I, Fabian I: Enhanced repopulation of murine hematopoietic organs in sublethally irradiated mice after treatment with ciprofloxacin. Blood 1991:78:1685-1691.
6. Roche Y, Gougcrot-Pocidalo MA, Fay M, Etienne D, Forest N, Pocida-lo JJ: Comparative effects of quino-iones on human mononuclear lcuco-cyte functions. J Antimicrob Che-mother 1987;19:781-790.
7. Nagafuji T, Matsumoto T, Takaha-shi K, Kudo S, Haraoka M, Tanaka M, Ogata N, Kumazawa J: Enhancement of superoxide production of polymorphonuclear neutrophils by ofloxacin and the effects of the inhibitors of protein kinascC. Chemotherapy 1993;39:70-76.
8. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
9. Decker T, Lohmann-Matthes ML: A quick and simple method for the quantitation of lactate dehydrogenase release in measurement of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 1988;115:61-69.
10. Bailly S, Fay M, Roche Y, Gougerot-Pocidalo MA: Effects of quinolones on tumor necrosis factor production by human monocytes. Int J Immu-nopharmacol 1990;12:31-36.
11. Endrcs S, Fülle HJ, Sinha B, Stoll D, Dinarello CA, Gerzer R. Weber PC: Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor-a and interleukin-ip by human mononuclear cells, immunology 1991;72:56-60.
12. Bailly S, Fcrrua B, Fay M, Gouge-rot-Pocidalo MA: Differential regulation of IL6, ILla, ILip and TNFa production in LPS-stimulated human monocytes: Role of cyclic AMP. Cytokine 1990:2:205-210.
13. Viherluoto J, Palkam TOS, Hurmc M: Cyclic adenosine monophosphate decreases secretion, but not the cell-associated levels of interleukin-13, in lipopolysaccharidc-acti-vatcd monocytes. Scand J Immunol 1991;34:121-125.
14. Rcnz H, Gong JH, Schmidt A, Nain M, Gemsa D: Release of tumor necrosis factor-a from macrophages: Enhancement and suppression arc dose-dcpcndcntly regulated by prostaglandin E2 and cyclic nucleotides. J Immunol 1988;141:2388-2393.
15. Scales WE, Chensue SW, Otterness I, Kunkel SL: Regulation of monokine gene expression: Prostaglandin E2 suppresses tumor necrosis factor but not interleukin-la or I-mRNA and cell-associated bioactivity. J LeukocBiol 1989;45:416-421.