The mutation rate of the human mtDNA deletion mtDNA4977

American Journal of Human Genetics

Volumn 59, Issue 4, 1996, Pages 772-780

  Shenkar, R ^b   Navidi, William ^b   Tavaré, Simon ^a   Dang, Mark H ^b   Chomyn, Anne ^b   Attardi, Giuseppe ^b   Cortopassi, Gino ^b   Arnheim, Norman ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; ARTICLE; FEMALE; FIBROBLAST; GENE DELETION; HUMAN; HUMAN CELL; MUTATION RATE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; CELL LINE; CLONE CELLS; DNA, MITOCHONDRIAL; FEMALE; GENE DELETION; HUMANS; MODELS, GENETIC; POLYMERASE CHAIN REACTION;

EID: 0029817147     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Corral-Debrinski M, Horion T, Lott MT, Shoffner JM, Beal MF, Wallace DC (1992) Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 2:324-329
2. Corral-Debrinski M, Stepian G, Shoffner JM, Lott MT, Kanter K, Wallace DC (1991) Hypoxemia is associated with mitochondrial DNA damage and gene induction: implications for cardiac disease. JAMA 266:1812-1816
3. Cortopassi GA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older individuals. Nucleic Acids Res 18:6927-6933
4. Cortopassi GA, Shibata D, Soong N-W, Arnheim N (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Nat Acad Sci USA 89:7370-7374
5. DiMauro S, Wallace DC (1993) Mitochondrial DNA in human pathology. Raven Press, New York
6. Yoneda M, Chomyn A, Martinuzzi A, Hurko O, Attardi G (1992) Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy. Proc Nat Acad Sci USA 89:11164-11168
7. Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P (1992) Multiple mtDNA deletions in an elderly individual. FEBS Lett 297:34-38