Acetylcarnitine modulation of the morphology of rat hippocampal synapses

Analytical and Quantitative Cytology and Histology

Volumn 18, Issue 4, 1996, Pages 275-278

  Bertoni Freddari, Carlo ^a   Fattoretti, Patrizia ^a   Caselli, Ugo ^a   Paoloni, Roberta ^a  

^a Neurobiology of Aging Laboratory   (Italy)

Author keywords

acetylcarnitine; hippocampus; morphometry; synapses

Indexed keywords

ACETYLCARNITINE;

ADOLESCENT; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; COMPUTER ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MODULATION; MORPHOMETRICS; NERVE CELL PLASTICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SYNAPSE; ULTRASTRUCTURE;

ACETYLCARNITINE; ANIMALS; HIPPOCAMPUS; MALE; RATS; RATS, INBRED F344; SYNAPSES;

ANIMALIA;

EID: 0029816845     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Caselli U: Dynamic morphology of the synaptic junctional areas during aging: The effect of chronic acetyl-L-carnitine administration. Brain Res 1994;656:359-366
2. Bertoni-Freddari C, Fattoretti P, Casoli T, Meier-Ruge W, Ulrich J: Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease. Brain Res 1990;517:69-75
3. Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Meier-Ruge W, Ulrich J: Morphological plasticity of synaptic mitochondria during aging. Brain Res 1993;628:193-200
4. Bertoni-Freddari C, Giuli C, Pieri C, Paci D: Quantitative investigation of the morphological plasticity of synaptic junctions in rat dentate gyrus during aging. Brain Res 1986; 366:187-192
5. Calvani M, Koverech A, Caruso G: Treatment of mitochondrial diseases. In Mitochondrial DNA in Human Pathology Edited by S DiMauro, DC Wallace. New York, Raven Press, 1993, pp 173-198
6. Calverley RKS, Jones DG: Contributions of dendritic spines and perforated synapses to synaptic plasticity. Brain Res 1990;15:215-249
7. Carlin RK, Siekevitz P: Plasticity in the central nervous system: Do synapses divide? Proc Natl Acad Sci USA 1983;80: 3517-3521
8. Cotman CW, Nieto-Sampedro N, Harris EW: Synapse replacement in the nervous system of adult vertebrates. Physiol Rev 1981;61:684-784
9. Dekosky ST, Scheff SW: Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 1990;27:457-464
10. Dyson SE, Jones DG: Synaptic remodelling during development and maturation: Junction differentiation and splitting as a mechanism for modifying connectivity. Dev Brain Res 1984;13:125-137
11. Greenough WT, Bailey CH: The anatomy of a memory: Convergence of results across a diversity of tests. Trends Neurol Sci 1988;11:142-147
12. Nieto-Sampedro M, Hoff SF, Cotman CW: Perforated postsynaptic densities: Probable intermediates in synapse turnover. Proc Natl Acad Sci USA 1982;79:5718-5722
13. Scheff SW, Dekosky ST, Price DA: Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990;11:29-37
14. Smith CB: Aging and changes in cerebral energy metabolism. Trends Neurol Sci 1984;7:203-208
15. Wallace DC: Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science 1992;256:628-632