Tissue-specific regulation of the WT1 locus

Medical and Pediatric Oncology

Volumn 27, Issue 5, 1996, Pages 456-461

  Hewitt, Judith A ^a   Kessler, Patricia M ^a   Campbell, Christine E ^a   Williams, Bryan R G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

kidney development; transgenic mice; Wilms' tumor

Indexed keywords

BETA GALACTOSIDASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CHROMOSOME 11P; COSMID; EMBRYO; LEYDIG CELL; MOUSE; NEPHROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); CHIMERA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; COSMIDS; DNA, NEOPLASM; DNA-BINDING PROTEINS; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENES, WILMS TUMOR; HUMANS; KIDNEY; KIDNEY GLOMERULUS; LEYDIG CELLS; MALE; MICE; MICE, TRANSGENIC; SPLEEN; TRANSCRIPTION FACTORS; UROGENITAL SYSTEM; UTERUS; WT1 PROTEINS; ZINC FINGERS;

EID: 0029816465     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-911X(199611)27:5<456::AID-MPO12>3.0.CO;2-8     Document Type: Article

References (24)

1. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R: WT1 is required for early kidney development. Cell 74:679-691, 1993.
2. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D, van Heyningen V, Hastie N: The candidate Wilms' tumour gene is involved in genitourinary development. Nature 346:194-197, 1990.
3. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE: Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol 11:1707-1712, 1991.
4. Pelletier J, Schalling M, Buckler AJ, Rogers A, Haber DA, Housman D: Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev 5:1345-1356, 1991.
5. Armstrong JF, Pritchard-Jones K, Bickmore W, Hastie ND, Bard JBL: The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev 40:85-97, 1992.
6. Rackley RR, Flenniken AM, Kuriyan NP, Kessler PM, Stoler MH, Williams BRG: Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis. Cell Growth Diff 4:3023-1031, 1993.
7. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE: Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60:509-520, 1990.
8. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE: Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci 88:9618-9622, 1991.
9. Pelletier J, Bruening W, Kashtan CE, Mauer SM, Manivel JC, Striegel JE, Houghton DC, Junien C, Habib R, Fouser L, Fine RN, Silverman BL, Haber DA, Housman D: Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 67:437-447, 1991.
10. Drummond IA, Rupprecht HD, Rohwer-Nutter P, Lopez-Guisa JM, Madden SL, Rauscher FJ, Sukhatme VP: DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1. Mol Cell Biol 14:3800-3809, 1994.
11. Harrington MA, Konicek B, Song A, Xia XL, Fredericks WJ, Rauscher FJ: Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus. J Biol Chem 268:21271-21275, 1993.
12. Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ, Sens DA, Garvin AJ, LeRoith D, Roberts CT: Increased expression of the insulin-like growth factor I receptor gene, IGF1 R, in Wilms' tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms' tumor gene product. Proc Natl Acad Sci 90:5828-5832, 1993.
13. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJ: Repression of the insulin-like growth factor II gene by the Wilms' tumor suppressor WT1. Science 257:674-678, 1992.
14. Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ, Kim SJ: Repression of the transforming growth factor-b1 gene by the Wilms' tumor suppressor WT1 gene product. Mol Endocrin 8:595-602, 1994.
15. Ryan G, Steele-Perkins V, Morris JF, Rauscher FJ, Dressler GR: Repression of Pax-2 by WT1 during normal kidney development. Development 121:867-875, 1995.
16. Hofmann W, Rover HD, Drechsler M, Schneider S, Royer-Pokora B: Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8:3123-3132, 1993.
17. Rupprecht HD, Drummond IA, Madden SL, Rauscher FJ, Sukhatme VP: The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269:6198-6206, 1994.
18. Campbell CE, Haung A, Gurney AL, Kessler PM, Hewitt JA, Williams BRG: Antisense transcripts and protein binding motifs within the Wilms' tumor (WT1) locus. Oncogene 9:583-595, 1994.
19. Frazier GC, Wu YJ, Hewitt SM, Maity T, Ton CCT, Huff V, Saunders GF: Transcriptional regulation of the human Wilms' tumor gene (WT1). J Biol Chem 269:8892-8900, 1994.
20. Malik KTA, Poirier V, Ivins SM, Brown KW: Autoregulation of the human WT1 gene promoter. FEBS Lett 349:75-78, 1994.
21. Wu YJ, Frazier GC, Saunders GF: GATA1I transactivates the WT1 hematopoietic specific enhancer J Biol Chem 270:5944-5949, 1995.
22. Frazier GC, Hewitt SM, Wu YJ, Maity T, Saunders GF: Identification and characterization of the regulatory regions of the human WT1 gene in kidney and hematopoietic cells. Proc Am Ass Cancer Res 34:539, 1993.
23. Hogan B, Beddington R, Constantini F, Lacy E: "Manipulating the Mouse Embryo." Cold Spring Harbor, NY: Cold Spring Harbor Press, 1994.
24. Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S, Coppes MJ, Law DJ, Feinberg AP, Yeger H, Williams BRG: Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms' tumor. Science 250:991-994, 1990.