Influence of pentobarbitone on in-vivo local disposition of diclofenac in rat liver

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 8, 1996, Pages 866-869

  Tabata, Kenji ^a   Yamaoka, Kiyoshi ^a   Yasui, Hiroyuki ^a   Fukuyama, Takako ^a   Nakagawa, Terumichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BARBITURIC ACID DERIVATIVE; DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOBARBITAL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILE SECRETION; BILIARY EXCRETION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; FEMORAL VEIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; LIVER; LIVER SINUSOID; MALE; MEAN RESIDENCE TIME; NONHUMAN; PORTAL VEIN; RAT; STATISTICAL ANALYSIS;

EID: 0029816139     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb03989.x     Document Type: Article

References (15)

1. Bailey, D. G., Paul, H., Johnson, G. E. (1975) Pentobarbital inhibits the biliary excretion of organic acids: a study with succinylsulphathiazole in the rat. Can. J. Physiol. Pharmacol. 53: 470-474
2. Bramer, S. L., Au, J. L.-S., Wientjes, M. G. (1993) Gastrointestinal and hepatic first-pass elimination of 2′,3′-dideoxyinosine in rats. J. Pharmacol. Exp. Ther. 265: 731-738
3. Daemen, M. J. A. P., Thijssen, H. H. W., Vervoort-Peters, H. T. M., Smits, J. F. M., Boudier, H. A. J. S. (1986) The effect of pentobarbitone anaesthesia and hypothermia on the hepatic clearance of indocyanine green and S( - )-acenocoumarol in the rat. J. Pharm. Pharmacol. 38: 122-125
4. Daemen, M. J. A. P., Thijssen, H. H. W., Van Essen, H., Vervoort Peters, H. T. M., Prinzen, F. W., Struyker Boudier, H. A. J., Smith, J. F. M. (1989) Liver blood flow measurement in the rat, the electromagnetic versus the microsphere and the clearance methods. J. Pharmacokin. Biopharm. 21: 287-297
5. Davies, B., Morris, T. (1993) Physiological parameters in laboratory animals and humans. Pharm. Res. 10: 1093-1095
6. Fukuyama, T., Yamaoka, K., Ohata, Y., Nakagawa, T. (1994) A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats. Drug. Metab. Dispos. 20: 541-546
7. Hadengue, A., Lee, S. S., Koshky, A., Girod, C., Lebrec, D. (1988) Regional blood flows by the microsphere method. Reproducibility in portal hypertensive rats and influence of a portal vein catheter. Proc. Soc. Exp. Biol. Med. 187: 461-468
8. Hoffman, D. J., Seifert, T., Boore, A., Nellans, H. N. (1995) Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling. Pharm. Res. 12: 889-894
9. Hori, R., He, Y., Shima, T., Inui, K., Aoki, S., Okumura, K., Tanigawara, Y. (1992) Total body and hepatic clearance in rats of recombinant tissue-type plasminogen activator expressed in mouse C127 and Chinese hamster ovary cells. Drug Metab. Dispos. 20: 541-546
10. Kakutani, T., Endo, K., Nara, E., Nakazora, S., Hashida, M. (1992) Effect of chronic administration of phenobarbital on the hepatobiliary transport of phenol red: assessment by statistical moment analysis. Pharm. Res. 9: 908-914
11. Riess, W., Stierlin, H., Degan, P., Faigle, J. W., Gerardiin, A., Moppert, J., Sallmann, A., Schmid, K., Schweizer, A., Sulc, M., Theobald, W., Wagner, J. (1978) Pharmacokinetics and metabolism of the anti-inflammatory agent voltaren. Scand. J. Rheumatol. Suppl. 22: 17-29
12. Stierlin, H., Faigle, J. W., Sallmann, A., Richter, W. J., Kriemler, H.-P., Alt, K. O., Winkler, T. (1979) Biotransformation of diclofenac sodium (voltaren) in animal and in man 1. Isolation and identification of principal metabolites. Xenobiotica. 9: 601-610
13. Tabata, K., Yamaoka, K., Fukuyama, T., Nakagawa, T. (1995) Evaluation of intestinal absorption into the portal system in enterohepatic circulation by measuring the difference in portal-venous blood concentrations of diclofenac. Pharm. Res. 12: 880-883
14. Tsuchiya, T., Terakawa, M., Ishibashi, K., Noguchi, H., Kato, R. (1980) Disposition and enterohepatic circulation of diclofenac in dogs. Arzneim. Forsch. 30: 1650-1653
15. Yamaoka, K., Nakagawa, T., Uno, T. (1978) Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm. 6: 547-558