Biochemical and cognitive studies of apolipoprotein-E-deficient mice

Molecular and Chemical Neuropathology

Volumn 28, Issue 1-3, 1996, Pages 97-103

  Gordon, Irit ^a   Genis, Idit ^a   Grauer, Ettie ^b   Sehayek, Ephraim ^c   Michaelson, Daniel M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Apolipoprotein E; choline acetyltransferase; cytoskeleton; hippocampus; hyperphosphorylation of ; memory; Morris water maze; phosphorylation of ; striatum; protein

Indexed keywords

APOLIPOPROTEIN E; CHOLINE ACETYLTRANSFERASE; EPITOPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL FUNCTION; COGNITION; CONFERENCE PAPER; DEPHOSPHORYLATION; ENZYME ACTIVITY; HYPERLIPOPROTEINEMIA TYPE 3; HYPERPOLARIZATION; IMMUNOBLOTTING; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TASK PERFORMANCE;

ANIMALIA;

EID: 0029815973     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815210     Document Type: Conference Paper

References (16)

1. Binder L. I., Frankfurter A., and Ribhum L. I. (1985) The distribution of tau in the mammalian central nervous system. J. Cell. Biol. 101, 1371-1378.
2. Buresova O., Bolhuis J. J., and Bures J. (1986) Differential effects of cholinergic blockade on performance of rats in the water tank navigation task and in radial water maze. Behav. Neurosci. 100, 476-482.
3. Goedert M., Jakes R., Crowther R. A., Cohen P., Vanmechelen E., Vandermerven M., and Cas P. (1994) Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein. Biochem. J. 301, 871-877.
4. Grauer E. and Kapon J. (1993) Wistar-Kyoto rats in the Morris swim maze: impaired working memory and hyperactivity to stress. Behav. Brain Res. 59, 147-151.
5. Masliah E., Mallory M., Alford M., and Mucker L. (1994) Abnormal synaptic regeneration in hAPP transgenic and apoE knockout mice. Neurobiol. Aging 15 S, 46.
6. 695 transgenic and apoE knockout mice, in Research Advances in Alzheimer's Disease and Related Disorders (Iqbal K., Mortimer J. A., Winblad B., and Wisniewski H. M., eds.), John Wiley, Chichester, pp. 405-414.
7. Mawal-Dewan M., Henley J., Van de Voorde A., Trojanowski J. Q., and Lee V. M.-Y. (1994) The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatase. J. Biol. Chem. 269, 30, 981-30, 987.
8. Morishima-Kawashima M., Hasegawa M., Takio K., Suzuki M., Yoshida H., Titani K., and Ihava Y. (1995) Proline directed and non-proline directed phosphorylation of PHF-tau. J. Biol Chem. 270, 823-829.
9. Morris R. (1984) Development of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47-60.
10. Namba Y., Tomanaga M., Kawasaki H., Otomi E., and Ikada K. (1991) Apolipo-protein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and Kuru plaque amyloid in Creutzfeld-Jacob disease. Brain Res. 541, 163-166.
11. Olton D. S. (1986) Hippocampal function and memory for temporal context, in The Hippocampus, vol. 4 (Isaacson, R. L. and Pribram, K. H., eds.), Plenum, New York, pp. 281-298.
12. Plump A. S., Smith J. D., Hayek T., Aalto-Setala K., Walsh A., Verstuyff J. G., Rubin E. M., and Breslow J. L. (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 16, 343-353.
13. Poirier J. (1994) Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 17, 525-530.
14. Roses A. D. (1994) Apolipoprotein E affects the rate of Alzheimer's disease expression: β-amyloid burden is a secondary consequence dependent on ApoE genotype and duration of disease. J. Neuropathol. Exp. Neurol. 53, 429-437.
15. Selkoe D. 5. (1994) Alzheimer's disease: A central role for amyloid. J. Neuropathol Exp. Neurol. 53, 438-447.
16. Wisniewski T. and Frangione B. (1992) Apolipoprotein E: A pathological chaperon protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135, 235-238.