Acetaminophen (Paracetamol) use and blood concentration in pain patients

Pain Digest

Volumn 6, Issue 4, 1996, Pages 215-218

  Heavner, James E ^a   Shi, Bing ^a   Diede, James ^a   Racz, Gabor ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL;

ARTICLE; BLOOD; BLOOD LEVEL; LOW BACK PAIN; PAIN; SACROILIAC JOINT;

EID: 0029815864     PISSN: 09389016     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Insel PA: Analgesic-antipyretics and antiinflammatory agents; drugs employed in the treatment of rheumatoid arthritis and gout. In Gilman AG, Rall TW, Nies AS et al (eds): The Pharmacological Basis of Therapeutics, ed 8. New York, Pergamon Press, 1990, pp 638-681.
2. Whitcomb DC, Block GD: Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994;272:1845-1850.
3. Perneger TV, Whelton PK, Klag MJ: Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal anti-inflammatory drugs. N Engl J Med 1994;331:1675-1679.
4. Strom BL: Adverse reactions to over-the-counter analgesics taken for therapeutic purposes. JAMA 1994;272:1866-1867.
5. Tietz NW, Logan NM: Appendix. In Textbook of Clinical Chemistry. Philadelphia, WB Saunders Company, 1986, p 1851.
6. Girre C, Hispard E, Palombo S et al: Increased metabolism of acetaminophen in chronically alcoholic patients. Alcohol Clin Exp Res 1993;17:170-173.
7. Mitchell JR, Hollow DJ, Potter WZ et al: Paracetamol-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 1973;187:185-194.
8. Guengerich FT, Beaune PH, Umbenhauer DR et al: Cytochrome P450 enzymes involved in genetic polymorphism of drug oxidation in man. Biochem Soc Trans 1987;15:576-578.
9. Black M, Raucy J: Acetaminophen, alcohol, and cytochrome P450. Ann Int Med 1986;104:427-428.